[PDF] Top 20 Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice
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Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice
... avian H5N1 influenza viruses in domesticated and wild birds continues to pose a threat to public health, as interspecies transmission of virus has resulted in increasing numbers of human disease ... See full document
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Cell-Cell Fusion Induced by Measles Virus Amplifies the Type I Interferon Response
... IFN response in cDC relies principally on RLR (RIG-I and MDA-5) (34, 35), which are cytosolic PRR expressed in almost all nucleated cells and dedicated to respond to viral nucleic acids produced during ... See full document
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Role of Type I Interferon Signaling in Human Metapneumovirus Pathogenesis and Control of Viral Replication
... ⫺/⫺ mice) diminished the HMPV-specific CD8 ⫹ T cell ...the virus after infection and developed significantly higher antibody titers, they displayed less overall disease and lung inflammation than ... See full document
16
Type I interferon response affects an inoculation dose independent mortality in mice following Japanese encephalitis virus infection
... dose response curve from this organism after peripheral infection and the reason for it has not yet been fully ...vigorous Type-I IFN (IFN-I) response might control early ... See full document
7
PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus Replication and Host Response
... A virus (IAV) can infect diverse host species, from wild and domestic birds to mammalian species, and the pathogenesis of IAV is complex due to its remarkable genetic ...regulate virus replication in ... See full document
17
Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit Influenza A Virus Replication
... positive- control siRNA against the viral nucleoprotein (NP), or a negative- control nontargeting ...universal type I IFN (1,000 ...and virus titers were determined by plaque ...on ... See full document
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Type I Interferon Response Limits Astrovirus Replication and Protects against Increased Barrier Permeability In Vitro and In Vivo
... of type I IFN in astrovirus control and pathogenesis in vivo by characterizing a new mouse model of astrovirus ...C57BL/6 mice with MuAstV-positive fecal filtrate results in productive in- ... See full document
9
PA from an H5N1 highly pathogenic avian influenza virus activates viral transcription and replication and induces apoptosis and interferon expression at an early stage of infection
... Type I interferon is induced in virus-infected cells by a signal transduction pathway beginning with retinoic- acid-inducible gene-I (RIG-I), which recognizes 5 ′ - ... See full document
13
Host Regulatory Network Response to Infection with Highly Pathogenic H5N1 Avian Influenza Virus
... of influenza virus-infected children (40), but its role in influ- enza pathogenesis has not been ...in mice, CCL7 exhibited profound early upregulation, supporting a role for airway epithelium ... See full document
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Highly Pathogenic Avian Influenza H5N1 Viruses Elicit an Attenuated Type I Interferon Response in Polarized Human Bronchial Epithelial Cells
... of influenza virus replication in humans, the aim of this study was to estab- lish a human respiratory epithelial cell model to better under- stand the virulence of avian H5N1 viruses relative ... See full document
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The Alpha/Beta Interferon Receptor Provides Protection against Influenza Virus Replication but Is Dispensable for Inflammatory Response Signaling
... wild-type mice exhibited decreased rates of mor- tality and viral replication in the brain and spleen compared with IFN- ␣ R ⫺/⫺ mice; levels of viral replication in the lungs were ... See full document
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A single immunization with HA DNA vaccine by electroporation induces early protection against H5N1 avian influenza virus challenge in mice
... in mice (Figures 2 and ...immune response, was detectable in mice on the 3rd day after immunization, reached its highest value on the 10th day and then gradually ...H5 virus HA DNA could ... See full document
9
The H5N1 Influenza Virus NS Genes Selected after 1998 Enhance Virus Replication in Mammalian Cells
... HK97 virus binds CPSF30, we transfected 293T cells with a plasmid expressing 3 ⫻ FLAG-CPSF30 or as a control with an empty ...Ud/NS-HK97 virus for 12 ...HK97 virus coimmunoprecipi- tated with ... See full document
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Effect of human activated NRAS on replication of delNS1 H5N1 influenza virus in MDCK cells
... as influenza virus (delNS1 strain), hepa- titis B virus, reovirus, vesicular stomatitis virus (VSV) and adenovirus (VAI mutant) ...B Virus infected cells, which increased the viral ... See full document
5
Engineered Small-Molecule Control of Influenza A Virus Replication
... immune response following vaccination and/or tracking of IAV infections in vaccinated individuals (8, ...live virus (10–12). In the event of vaccine failure and uncontrolled virus replication, ... See full document
11
Efficacy of Parainfluenza Virus 5 Mutants Expressing Hemagglutinin from H5N1 Influenza A Virus in Mice
... Construction of plasmids containing full-length PIV5 genomes and HA. To generate a plasmid containing H5-HA insertion between the HN and L genes in the PIV5 ⌬ SH genome (PIV5 ⌬ SH-H5), the plasmid pPIV5 ⌬ SH containing ... See full document
6
Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice
... of influenza viruses in different ...different virus strains (1, 11, 15, 17, 39, ...the replication and virulence of different avian influ- FIG 4 Truncated PB1 and vRNA binding ... See full document
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Inhibition of the Type I Interferon Response by the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus
... of type I IFN is inhibited in A549/LCMV-Pi ...infectious virus in A549/LCMV-Pi cells were assessed by IF and infectious center assay, ...a control, A549 cells were treated with 500 IU/ml of ... See full document
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protein of avian influenza virus H5N1
... reverse transcriptase (Promega, Madison, USA ). The NS1 gene of AIV A/Chicken/Malaysia/5858/2004 (H5N1) was amplified from the first-strand c DNA using the Accura High-Fidelity DNA polymerase (Lucigen Corporation, ... See full document
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H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load
... faster replication; thus, viruses containing these muta- tions are often more pathogenic in mice (18, 27, ...PR8 virus adapted to induce severe disease in Mx1-positive mice found several ... See full document
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