[PDF] Top 20 Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation
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Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation
... the endostar and endostar nanoparticle-treated groups (Figure ...the endostar group and 5.5 days in endostar-loaded nanoparticle group versus ...the endostar group, 77.75% in the ... See full document
10
Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acid-poly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate
... in vivo tumor cell apoptosis was investigated by terminal deoxy- nucleotidyl transferase dUTP nick end labeling (TUNEL) assay using an apoptotic cell detection kit (KeyGen Bio- tech, Nanjing, People’s Republic of ... See full document
16
<p>Applications of daunorubicin-loaded PLGA-PLL-PEG-Tf nanoparticles in hematologic malignancies: an in vitro and in vivo evaluation</p>
... Materials and methods: DNR-loaded NPs were prepared by the modified double-emulsion solvent evaporation/diffusion method, and its microscopic form was observed under scanning electron microscope. Intracellular ... See full document
9
PREPARATION, CHARACTERIZATION AND IN VITRO - IN VIVO EVALUATION OF GLICLAZIDE LOADED POLYMERIC MICROSPHERES
... After checking those compatibility parameter optimized two formulations was chosen for in vivo anti-diabetic study. Both the formulation of Ethocel and Methocel K15M and Ethocel and Eudragit-RSPO combination ... See full document
10
Preparation and in vivo evaluation of insulin loaded biodegradable nanoparticles prepared from diblock copolymers of PLGA and PEG
... insulin loaded NP by a double emulsion technique uses either sonication or homogenisation as a source of high shear agitation (Blum and Saltzman, ...PEGylated PLGA during formation of the primary emulsion ... See full document
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Original Article Preparation of compound ornidazole/pefloxacin PLGA microspheres and evaluation of the pharmacological effect on chronic periodontitis
... ornidazole/pefloxacin-loaded PLGA sustained microspheres with optimized characteristics and in vivo evaluation of the pharmacological effect on chronic ...in vitro released about 95% by ... See full document
11
Preparation and Evaluation of Rifampicin Ascorbic Acid Loaded Plga Nanoparticles.
... metabolism. PLGA degrades through hydrolysis of its ester linkages in the presence of ...of PLGA is related to the ratio of monomers used in its production: the higher the content of glycolide units, the ... See full document
99
Trastuzumab- and Fab′ fragment-modified curcumin PEG-PLGA nanoparticles: preparation and evaluation in vitro and in vivo
... In vitro cellular uptake experiments showed that Fab ′ -NPs exhibited enhanced cellular accumu- lation compared with ...in vivo demonstrated that Fab ′ -NPs expressed higher tumor permeability and longer ... See full document
10
Preparation and in vitro evaluation of doxorubicin-loaded Fe3O4 magnetic nanoparticles modified with biocompatible copolymers
... then PLGA-PEG copolymer was used to encapsulate Fe 3 O 4 nanoparticles by an emulsion method ...in vitro cytotoxicity study demonstrated that the PLGA-PEG nanoparticles ... See full document
16
In vitro evaluation of 5-aminolevulinic acid (ALA) loaded PLGA nanoparticles
... ALA PLGA NPs work mainly through increasing the amount and rate of PpIX formation to enhance the efficiency of the photodynamic ...ALA PLGA NPs ...that PLGA NPs increased the killing effects of ... See full document
8
PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies
... PGZ-loaded nanoparticles (PGZ-NPs) were synthesized by the solvent displacement technique, following a factorial design using poly (lactic-co-glycolic acid) polyethylene glycol ...in vitro, using a ... See full document
14
<p>Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats</p>
... APM-loaded PLGA NPs to increase the bioavailability and sustain the release of ...in vitro release study and in vivo pharmacoki- netic ...APM-loaded PLGA NPs can therefore be ... See full document
9
Pigment epithelial-derived factor gene loaded novel COOH-PEG-PLGA-COOH nanoparticles promoted tumor suppression by systemic administration
... in vitro antitumor effect was found in both C26 and A549 cells treated by D-NPs, in which PEDF levels were dramatically elevated due to the successful transfection of PEDF ...in vitro and inhibited the ... See full document
17
Pharmacokinetics and Tissue Distribution of PLGAPLL- PEG-TF Nanoparticles Loaded with Daunorubicin and Tetrandrine Following Intravenous Injection in the Rats Using LC-MS/MS
... in vitro release showed that 90% of free drugs were released in 3h, while only 50% to 60% drugs were released from the D/T- PPP-NPs-Tf in 24 ...in vivo compared with free ...Usually PEG was regarded ... See full document
12
SELF ASSEMBLED BIODEGRADABLE POLYMERIC NANOPARTICLES WITH IMPROVED SOLUBILITY OF CARVEDILOL: PREPARATION, CHARACTERISATION AND IN VITRO RELEASE KINETICS
... (EC, PEG, and PLGA-PEG) on the morphological characteristics, the prepared CVD-loaded NPs (-EC-NPs, -PEG- NPs and -PLGA-PEG-NPs) were visualized under Scanning Electron ... See full document
15
ANTIOXIDANT ACTIVITY EVALUATION METHODS:IN VITRO AND IN VIVO
... Free radicals are molecules or molecular fragments containing one or more unpaired electrons. Oxidative stress occurs due to free radical generation and deficiency of antioxidant defence mechanism. Oxygen consumption ... See full document
7
Delivery as nanoparticles reduces imatinib mesylate-induced cardiotoxicity and improves anticancer activity
... In vitro cellular uptake of nanoparticles was studied using curcumin-loaded PLGA nanoparticles ...These nanoparticles were prepared essentially as mentioned in the “Preparation ... See full document
8
Study of Human Serum Albumin SPIONs Loaded PLGA Nanoparticles for Protein Delivery
... polymeric PLGA nanopar- ...HSA-based nanoparticles can be well to- lerated without any serious side effects, which it is supported by clinical studies with registered HSA-based particle ...in ... See full document
10
Poly(lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted salinomycin delivery to CD133<sup>+</sup> osteosarcoma cancer stem cells
... nanoparticles were fully dissolved in 1 mL dichloromethane. The dichloromethane solution was evaporated in a vacuum evaporator and 5 mL methanol was added to form a clear solution sample for high performance ... See full document
18
Development of a porous poly(DL lactic acid co glycolic acid) based scaffold for mastoid air cell regeneration
... 20% PLGA/PEG-80% alginate, at ...40% PLGA/PEG-60% alginate scaf- folds (64% porous) were used in all subsequent ...in vivo studies to determine the best formulation to take forward for ... See full document
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