[PDF] Top 20 Enhancement of natural killer function through activation of the T11 E rosette receptor
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Enhancement of natural killer function through activation of the T11 E rosette receptor
... sensitive targets. Before and after induction, cytotoxicity was found predominantly within the NKH1+ population. These results suggest that several distinct mechanisms may be capable of enhancing NK activity and that the ... See full document
5
Gene expression profiling of the human natural killer cell response to Fc receptor activation: unique enhancement in the presence of interleukin-12
... including IFNG as well as various TNF family members, were transcriptionally up-regulated in response to co- stimulation. Of the top 150 genes differentially expressed in the Smith et al. study, nearly 10 % were ... See full document
17
Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus infected cells
... IL-2/anti-IL-2 monoclonal antibody complexes can over- come this problem. IL-2 in complex with anti-mouse IL-2 mAb S4B6 or anti-human IL-2 MAB602 is preferentially directed to the CD122 receptor subunit. Treatment ... See full document
12
Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
... Transient Receptor Potential (TRP) ion channels can trigger specific Ca 2+ -dependent signal transduction path- ways regulating many biological processes in both excitable and nonexcitable cells (Gees et ...in ... See full document
10
Scavenger receptors target glycolipids for natural killer T cell activation
... Scavenger receptors (SRs) comprise a large family of structur- ally diverse molecules that function as PRRs for both modified self and pathogenic non-self molecules (19). While first members of this family, such ... See full document
13
Soluble beta glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b opsonized target cells
... or natural killer (NK) cell CR3 adheres to iC3b on erythrocytes or tumor cells that lack CR3-binding membrane polysaccharides, neither lysis nor cytotoxicity are ...polysaccharides function ... See full document
13
Expression analysis of HLA E and NKG2A and NKG2C receptors points at a role for natural killer function in ankylosing spondylitis
... a multiwell plate with RPMI 1640 (Corning) with 10% fetal bovine serum (FBS), penicillin-streptomicin and glutamine (Corning). Phytohemagglutinin-M (PHA, Roche) was used as stimuli at 5 mg/mL concentration. Seventy-two ... See full document
8
Active but not inactive granulomatosis with polyangiitis is associated with decreased and phenotypically and functionally altered CD56dim natural killer cells
... fraction in active GPA. There were no significant differ- ences on further subtyping of CD56 dim NK cells accord- ing to the maturity markers CD62L and CD57. CD56 dim NK cells are characterized by the expression of the ... See full document
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Novel interleukin 2 (IL 2) receptor appears to mediate IL 2 induced activation of natural killer cells
... monoclonal anti-Tac antibody did not inhibit the cross-linking of 125I-IL-2 to the p70 binding sites present on NK cells. Functionally, the addition of high concentrations of recombinant IL-2 to the enriched NK cells ... See full document
7
Determination of natural killer cell function by flow cytometry.
... Fc receptor for immunoglobulin G and is present on NK cells and granulo- ...various activation states of the cells (3, 11, 12, 17, 22, 23, ...typical activation markers, such as the IL-2 re- ceptor ... See full document
6
The CD4 Receptor: An Indispensable Protein in T Cell Activation and A Promising Target for Immunosuppression
... CD4 receptor is the primary entry receptor for the human immunodeficiency ...detrimental function, the CD4 receptor is crucial for positive selection and development of CD4 + T cells as well ... See full document
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Activation of Natural Killer Cells by Newcastle Disease Virus Hemagglutinin-Neuraminidase
... cell activation by NDV are poorly understood so ...the natural cytotoxicity receptors NKp44 and NKp46, but not ...activating receptor NKG2D were partially ...direct activation of NK cells ... See full document
14
Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms
... in patients with certain leucocyte antigen (HLA). Signs and symptoms are different from the pharmacologic actions or the collateral effects of the drug. DA account for about 6–10% of all ADRs, but for up to 10% of the ... See full document
24
Uterine natural killer cells as modulators of the maternal fetal vasculature
... uNK cells also produce a variety of chemokines, including interleukin-8 (IL-8) and interferon-inducible protein-10 (IP-10). Receptors for these two chemokines, CXCR1 and CXCR3, respec- tively, are expressed on the ... See full document
7
Activation and regulation of B cell responses by invariant natural killer T cells
... cell activation and symptoms of disease in a model where circulating apoptotic cells trigger autoantibody production, resembling the situation in SLE patients ... See full document
11
Aberrant DR5 transport through disruption of lysosomal function suggests a novel mechanism for receptor activation
... observed using benzyl-α-galNAc (Supplementary Figure S6C). Therefore, mechanisms other than aberrant DR5 O-linked glycosylation cause lysosomal accumulation. Secondly, apart from being an important factor for the ... See full document
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Hofmeister, Valeska (2004): Expression und immunmodulatorische Funktion von HLA-G und seinen verkürzten Isoformen in Tumorzellinien. Dissertation, LMU München: Fakultät für Biologie
... Die zweite Gruppe inhibitorischer Rezeptoren wird durch Gene kodiert, die auf Chromosom 12 (12p12-p13) liegen. Sie werden auf NK-Zellen und einer Gruppe von zytotoxischen T- Zellen exprimiert (Aramburu et al. 1991). ... See full document
137
A HOT WAY LEADING TO HEALTHY STAY
... Mechanism of action: Capsaicin acts on TRPV1 receptors. This receptor is a non-selective, ligand-operated cationic channel located primarily in the small fibers of nociceptive neurons. It is also broadly ... See full document
5
Activation of human invariant natural killer T cells with a thioglycoside analogue of ? galactosylceramide
... Invariant natural killer T (iNKT) cells are unconventional regulatory and effector T cells that recognize glycolipid antigens presented by the major histocompatibility complex (MHC) class I-like molecule ... See full document
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Regulation of immunity during visceral Leishmania infection
... In our recent study, employing a non-human primate model of VL, hypergammaglobulinemia was established early after infection and persisted during the chronic phase. Yet, the production of Leishmania-specific IgG was ... See full document
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