[PDF] Top 20 Eph/ephrin signalling during development
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Eph/ephrin signalling during development
... of Eph and ephrin proteins Eph receptors are subdivided into two subclasses, termed EphA and EphB, based on sequence similarity and their preference for binding a particular subclass of ... See full document
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The role of the Eph ephrin signalling system in the regulation of developmental patterning
... of Eph and ephrin protein-protein interactions show that many of the receptors show cross-reactivity which is usually restricted to either GPI-linked or transmembrane ephrins (Gale et ...single Eph ... See full document
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Eph Signaling in Vascular Development
... As mentioned above, the expression of ephrinB2 in all arterial ECs, and the observed expression of only one EphB receptor in the vasculature, EphB4 Wang et aI., 1998, restricted to venou[r] ... See full document
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Ephrin B1 maintains apical adhesion of neural progenitors
... of development (Nievergall et al., 2012). A distinctive feature of the Eph/ephrin signaling pathway is the ability of both Eph receptors and ephrins to activate signal transduction cascades ... See full document
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Weinges, Stefan (2006): Molecular dissection of ephrinB reverse signaling. Dissertation, LMU München: Fakultät für Biologie
... Proper development of neurons is therefore vital to the mental health of an individual, and perturbations in their signaling or morphology are likely to result in cognitive ...The development of a neuron ... See full document
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Coordinated Eph-ephrin signaling guides migration and axon targeting in the avian auditory system
... molecules during development. We previously showed that several other Eph family proteins are expressed in NM and NL at the time that projections form ...soluble Eph fusion proteins to inhibit ... See full document
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EPH/ephrin profile and EPHB2 expression predicts patient survival in breast cancer
... and their ligands with opposite outcomes regarding tumor progression have been reported [11, 26]. For instance a recent study proposed that EPHB6 could decide the fate of the tumor by interacting with other receptors ... See full document
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The role of the Eph signalling pathway in epithelialisation of the somites
... Little is known about sclerotome specification in zebrafish. Sclerotome precursor cells can be identified by the expression o f twist, a gene encoding a bHLH transcription factor also expressed in the mouse sclerotome (W ... See full document
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Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord
... In vertebrates, motor neurons (MN) innervating skeletal muscles are born in the ventral neural tube, the future spinal cord, from a pool of progenitors located in the ventricular zone. As for other neuronal subtypes, the ... See full document
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Eph Ephrin signaling and focal adhesion kinase regulate actomyosin dependent apical constriction of ciliary band cells
... and no significant loss of apical constriction. We speculate that the non-canonical, Wnt planar cell polarity pathway is responsible for directing assembly of an actomyosin-regulating, Sp-Eph/FAK complex ... See full document
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Eph receptors and ephrin class B ligands are expressed at tissue boundaries in Hydra vulgaris
... Hydra vulgaris is a small freshwater polyp belonging to the phylum of cnidaria and thus evolved before bilaterians split off from the early metazoan phyla. Hydra is a simply built animal, consisting of a body column with ... See full document
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Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling
... is Eph/Ephrin signalling, which modulates adhesion via Integrins in other biological contexts (Pasquale, ...ligand Ephrin B2a are expressed in the anterior and posterior halves of nascent ... See full document
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The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum
... of signalling pathways including ephrin receptors and syn- aptic long-term potentiation (Table ...2). Ephrin ligands and receptors guide axons during neural development and regulate ... See full document
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On the role of Eph signalling in thymus histogenesis; EphB2/B3 and the organizing of the thymic epithelial network
... stages: E11.5 (12 μ m thickness), E13.5, E15.5, E17.5, newborn and adult (8 weeks) (6 μ m thickness), were fixed in acetone for 10 minutes and air dried. Cryosections were stained with either anti-keratin 5 (Covance, ... See full document
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EPHB4 kinase–inactivating mutations cause autosomal dominant lymphatic related hydrops fetalis
... here that kinase-inactivating mutations in EPHB4 can produce a lymphatic phenotype in humans that can be classified as LRHF/ GLD. However, this phenotype shows highly variable expression. Some individuals present with ... See full document
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Investigation of ephrin regulation during hindbrain segmentation
... 6 during neural development and kreisler mutants have patterning defects in the hindbrain that are not fully ...analyzing Eph/epbrin expression, we have found that while r5 fails to form in these ... See full document
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p120RasGAP mediates ephrin/Eph dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos
... Although ephrin/Eph signals are involved in a wide range of developmental processes, their underlying biological function is attributed principally to modulation of cytoskeletal organisation and cell ... See full document
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EPHA6 rs4857055 C > T polymorphism associates with hypertension through triglyceride and LDL particle size in the Korean population
... important role in endothelial cell dysfunction. The asso- ciation between HGF and hypertension severity has been established in several human studies [31, 32]. Linked with those previous studies, a Japanese study ... See full document
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Drosophila Eph receptor guides specific axon branches of mushroom body neurons
... Vertebrate Eph RTKs and their Ephrin ligands have been shown to play roles in many aspects of axon guidance, including midline crossing at the optic chiasm, retinotopic map formation and motoneuron ... See full document
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Paradoxes of the EphB1 receptor in malignant brain tumors
... kinases. Eph receptor-mediated forward and ephrin ligand- mediated reverse signalings are termed bidirectional ...that Eph/ephrin signaling regulates cell migration, adhesion, morphological ... See full document
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