[PDF] Top 20 Estimating the Effectiveness of Simian Immunodeficiency Virus-Specific CD8+ T Cells from the Dynamics of Viral Immune Escape
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Estimating the Effectiveness of Simian Immunodeficiency Virus-Specific CD8+ T Cells from the Dynamics of Viral Immune Escape
... of escape so that CTL killing is not underestimated. Viral variants are subject to a selection- versus-fitness balance that has important implications for the rational design of vaccines and for ... See full document
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With Minimal Systemic T-Cell Expansion, CD8+ T Cells Mediate Protection of Rhesus Macaques Immunized with Attenuated Simian-Human Immunodeficiency Virus SHIV89.6 from Vaginal Challenge with Simian Immunodeficiency Virus
... a CD8 ⫹ T-cell response in the different tissues did not correlate with control of viral ...the CD8 ⫹ T-cell response, including the cytokine profile and survival capacity of CD8 ... See full document
16
Conditional Immune Escape during Chronic Simian Immunodeficiency Virus Infection
... cytotoxic CD8 T cells play an essential role in the control of human immunodeficiency virus (HIV)/simian im- munodeficiency virus (SIV) ...potent immune ... See full document
8
Pyrosequencing Reveals Restricted Patterns of CD8+ T Cell Escape-Associated Compensatory Mutations in Simian Immunodeficiency Virus
... impede viral es- cape in this ...two specific codons in a relatively short period of time but also that these errors must generate specific amino acid substitutions which together are capable of ... See full document
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Early Establishment and Antigen Dependence of Simian Immunodeficiency Virus-Specific CD8+ T-Cell Defects
... human immunodeficiency virus (HIV)-specific CD8 ⴙ T cells may contribute to the failure of HIV-specific CD8 ⴙ T cells to control HIV ...whether ... See full document
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Detection of simian immunodeficiency virus (SIV)-specific CD8+ T cells in macaques protected from SIV challenge by prior SIV subunit vaccination.
... the CD8 1 CTL responses elicited post-SIV chal- lenge provide a marker for the occurrence of transient infec- tion postchallenge, the precise mechanism(s) by which immune responses induced by subunit ... See full document
7
Macaque Long-Term Nonprogressors Resist Superinfection with Multiple CD8+ T Cell Escape Variants of Simian Immunodeficiency Virus
... measure viral replicative ...reference virus bearing a genetic “barcode” of synonymous substitutions in gag that abrogated binding of the primers and probes used in our standard QRT-PCR diagnostic ...probes ... See full document
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Differential Dynamics of CD4+ and CD8+ T-Lymphocyte Proliferation and Activation in Acute Simian Immunodeficiency Virus Infection
... NK cells there was no detectable change in cell ...other viral infections (38). Mice infected with influenza A virus showed continued cycling of virus-specific CTLp over a 7-day period, ... See full document
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Antibodies to gp120 and PD-1 Expression on Virus-Specific CD8+ T Cells in Protection from Simian AIDS
... and CD8 ⫹ T-cell responses as well as mucosal immune responses against heterologous ...Ankara virus (MVA) (6–11), and genet- ically attenuated NYVAC or ALVAC (8, 12, 13) have been evalu- ated ... See full document
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Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection
... of immune escape observed in groups 1 and ...data from only four of the latter animals were available for this analysis, which limited our statistical power ...animals from our earlier study ... See full document
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Dynamics of Simian Immunodeficiency Virus Two-Long-Terminal-Repeat Circles in the Presence and Absence of CD8+ Cells
... IMPORTANCE CD8 ⫹ T cells play an essential role in controlling HIV and SIV infec- tion, but the specific mechanisms involved remain poorly ...failed viral infection, HIV and SIV can form 2-LTR ... See full document
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Dynamics of Cytokine/Chemokine Responses in Intestinal CD4+ and CD8+ T Cells during Acute Simian Immunodeficiency Virus Infection
... and CD8 ⫹ T ...of CD8 ⫹ -specific CCL4 may play an important role in immune response against SIV/HIV by inhibiting SIV/HIV repli- cation and killing of virus-infected ... See full document
8
Acute-Phase CD8 T Cell Responses That Select for Escape Variants Are Needed to Control Live Attenuated Simian Immunodeficiency Virus
... elicit CD8 T cell responses targeting conserved elements in the viral ...vaccine-specific immune responses should be present in most circulating virus populations (6, 40– ... See full document
12
Impairment of Gag-Specific CD8+ T-Cell Function in Mucosal and Systemic Compartments of Simian Immunodeficiency Virus mac251- and Simian-Human Immunodeficiency Virus KU2-Infected Macaques
... active CD8 ⫹ T cells in mucosal ...this specific peptide alone does not appear to be fully protective (15, 45), the identification of viral escape mutant viruses within this ... See full document
13
Recognition of Escape Variants in ELISPOT Does Not Always Predict CD8+ T-Cell Recognition of Simian Immunodeficiency Virus-Infected Cells Expressing the Same Variant Sequences
... the immune system ...human immunodeficiency virus (HIV), the AIDS vaccine field now also focuses on the development of vaccines that elicit effective CD8 ⫹ T-cell responses against HIV ... See full document
7
Limited Maintenance of Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8 T-Cell Receptor Clonotypes after Virus Challenge
... effective CD8 T cells that can respond to challenge and limit immune escape is a key goal of future T-cell-based vaccination ...modulate CD8 T-cell repertoires in ... See full document
12
Contribution of CD8+ T Cells to Containment of Viral Replication and Emergence of Mutations in Mamu-A*01-Restricted Epitopes in Simian Immunodeficiency Virus-Infected Rhesus Monkeys
... conferred escape from immune recognition were associated with com- pensatory changes outside the epitope (both upstream and downstream), suggesting that the targeted region was under structural ... See full document
5
Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost
... of escape mutations during acute infection in two of three ani- mals ...K165R virus during acute infection allows an estimation of the selection pressure exerted by KP9-specific ...went from ... See full document
11
The Antiviral Efficacy of Simian Immunodeficiency Virus-Specific CD8+ T Cells Is Unrelated to Epitope Specificity and Is Abrogated by Viral Escape
... in CD8 ⫹ T-cell efficacy and suggest that the antiviral efficacy of CD8 ⫹ T cells should be measured for individual epitopes and not general- ized by ...that CD8 ⫹ T ... See full document
11
Effective Simian Immunodeficiency Virus-Specific CD8+ T Cells Lack an Easily Detectable, Shared Characteristic
... The immune correlates of human/simian immunodeficiency virus control remain ...While CD8 ⴙ T lymphocytes likely play a major role in reducing peak viremia and maintaining ... See full document
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