[PDF] Top 20 Evidence That BRCA1- or BRCA2-Associated Cancers Are Not Inevitable
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Evidence That BRCA1- or BRCA2-Associated Cancers Are Not Inevitable
... Although Brca1 null strains can be generated in the mouse, homozy- gous loss of BRCA1 is incompatible with human ...mouse Brca1 mutation increases risks from car- cinogenic ... See full document
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Enhanced RAD21 cohesin expression confers poor prognosis in BRCA2 and BRCAX, but not BRCA1 familial breast cancers
... in BRCA2 and BRCX ...of BRCA1 tumors are ER a ...is associated with sensitivity to tamoxifen [35], whereas transduction by retroviral cDNA suggests that RAD21 expression is associated with ... See full document
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<p>Comparison of Patient Susceptibility Genes Across Breast Cancer: Implications for Prognosis and Therapeutic Outcomes</p>
... are associated with ele- vated risk for breast, ovarian 8 and peritoneal cancer in women, with breast cancer and prostate cancer in men, and, to a lesser degree, with pancreatic ...cancer. BRCA1/2 mutations ... See full document
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Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
... des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, et Equipe «Génétique du cancer du sein», Centre de Recherche en Cancérologie de Lyon: Laure Barjhoux, Carole Verny-Pierre, Sophie ... See full document
20
Parity and breast cancer risk among BRCA1 and BRCA2mutation carriers
... are associated with a lower risk of developing breast cancer and that the protective effect may be limited to carriers above the age of 40 ...among BRCA1 mutation carriers, but there were no statistically ... See full document
6
The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers
... cancer associated with BRCA1/2 mutations is reported higher in men diagnosed at an older age ...harbour BRCA1/2 mutations are believed to develop the disease at an early ...disease associated ... See full document
7
Identification of four novel susceptibility loci for estrogen receptor negative breast cancer
... breast cancers, is more common in women diagnosed at young age and in women of African ancestry 1 , and is associated with worse short- term outcome than ER-positive ...been associated with breast ... See full document
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Variation in breast cancer risk associated with factors related to pregnancies according to truncating mutation location, in the French National BRCA1 and BRCA2 mutations carrier cohort (GENEPSO)
... that BRCA1 acts during pregnancy. Indeed, BRCA1 is also involved in cellu- lar anti-proliferation via inhibition of the transcriptional activity of estrogen receptor a (ER a ) ...of BRCA1 corre- ... See full document
13
The Pathology of Hereditary Breast Cancer
... breast cancers associated with BRCA1 or BRCA2 germline mutations differ in their morphological and immunohistochemical ...characteristics. Cancers associated with BRCA1 ... See full document
8
Hereditary breast and ovarian cancer
... like BRCA1/2 should be taken into consideration also in such families (about 50% of BRCA1 mutation carriers with breast cancer come from unaffected families ...of cancers in such families are ... See full document
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Autoimmune response to PARP and BRCA1/BRCA2 in cancer
... emerging evidence indicates that most TAAs are cellular proteins whose aberrant regulation of function could be linked to ...non-tumor- associated antigens, because autoantibodies to other cellular antigens ... See full document
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Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1 associated breast cancers
... 77 BRCA1-associated breast cancers, we found similar frequencies of LOH with loss of wt BRCA1 in ER+ and ER- breast ...wt BRCA1 results in higher grade ductal cancers with higher ... See full document
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miRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers
... the BRCA2-N to BRCA2-C transition are involved in many similar processes, including epithelial junctions and ECM interaction (ACTA11, ACVR1B, CDLDN19, and FGF11), apoptosis (CASP2, and FAS), protein ... See full document
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Genomic patterns resembling BRCA1 and BRCA2 mutated breast cancers predict benefit of intensified carboplatin based chemotherapy
... resembling BRCA1- or 2-mutated breast cancers (BRCA-like CGH status) would identify a subgroup of not only TN, but also ER-positive, HER2-negative breast can- cer patients with tumors exquisitely sensitive ... See full document
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Contribution of the Defective BRCA1, BRCA2 and CHEK2 Genes to the Familial Aggregation of Breast Cancer: a Simulation Study Based on the Swedish Family-Cancer Database
... of BRCA1/2 mutations and CHEK2 variants to the relative risk of breast cancer for women with affected mothers or ...of BRCA1, BRCA2 and CHEK2 from the literature, was used to simulate the familial ... See full document
7
Risk Factors for Breast Cancer of Different Age Groups: Moroccan Data?
... the BRCA1 or BRCA2 genes (5% of all cancers), en- dogenous hormonal factors (early age at menarche, late menopause), exogenous hormonal factors (oral contra- ceptives, hormone replacement treatment), ... See full document
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BARD1 and Breast Cancer: the Possibility of Creating Screening Tests and New Preventive and Therapeutic Pathways for Predisposed Women
... in BRCA1 and BRCA2 are responsible for 16- 40% of hereditary breast and ovarian cancers and site-specific breast cancer; inTP53 is associated with up to 85% risk of developing breast cancer by ... See full document
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The pathology of familial breast cancer: Immunohistochemistry and molecular analysis
... of BRCA1- and BRCA2-associated breast tumours have been carried out in the few years since the identification of these familial breast cancer predisposing ...that BRCA1 tumours differ from ... See full document
5
The pathology of familial breast cancer: Morphological aspects
... breast cancers are due to a heritable ...genes, BRCA1 and BRCA2, have been identified and ...the BRCA1 and BRCA2 genes differ from each other and from sporadic breast ...independently ... See full document
5
Exome sequencing reveals a high prevalence of BRCA1 and BRCA2 founder variants in a diverse population-based biobank
... pathogenic BRCA1/2 variants in ap- parently healthy individuals has the potential to lead to earl- ier diagnosis of cancer via increased surveillance, as well as cancer risk reduction via prophylactic medical ... See full document
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