[PDF] Top 20 Evolutionary Dynamics and Global Diversity of Influenza A Virus

... species. Evolutionary analysis of 14 high-priority subtypes showed that nucleotide substitution rates for all subtypes except H5N3, H7N3, and H7N7 were higher in East Asian countries, including China, Hong Kong, ... See full document

... an influenza virus that has recently acquired a new host range and in the face of low levels of vaccine-induced immu- ...long-term evolutionary dynamics ob- served during persistent RNA ... See full document

... human influenza viruses do, and viral phylogenies exhibit geographical structure compatible with high levels of local ...avian influenza virus that had previously been ... See full document

... the evolutionary dynamics of EIV over very short time ...the evolutionary infectivity profile—the net transmission rate of immunologi- cally selected variants, which results from the interaction be- ... See full document

... A virus (IAV) hemagglutinin (HA) protein can eliminate neutralizing antibody binding to me- diate escape from preexisting antiviral ...the evolutionary dynamics of the HA protein has not been ...the ... See full document

... We examined the other alternative of increased tolerance through an analysis of the changes in frequency of amino acid mutations over the study period and found that large selective sweeps in both H1N1 and H3N2 lineages ... See full document

... epidemiological dynamics of rapidly evolving ...as influenza virus during the course of an ...pandemic influenza H1N1/09 virus genomes from United Kingdom isolates from the first (127 ... See full document

... of influenza vaccine strain components for local ...her influenza vaccination policy, the choice of broad immunity (Epstein 2018) or more valence vaccines ( ...viral diversity, a high-resolution ... See full document

... within-host dynamics of natural virus infection and the resulting immune responses underlie both the disease signs seen in infected hosts and virus transmission, thus providing the foundation for the ... See full document

... A virus (IAV) continues to pose an enormous and unpredict- able global public health threat, largely due to the continual evolution of escape from preexisting immunity and the potential for zoonotic ... See full document

... H5N1 virus entered Nigeria, another major unresolved question is the evolutionary basis for why certain sublineages thrive in Nigeria, particularly sublin- eages II and I/II-N, while sublineages I and III ... See full document

... genealogical diversity is restricted by evolution in the two-dimensional antigenic ...Reduced diversity is substantially more common in models with less muta- tion or models with less variable mutation ... See full document

... Hui Tao, John Steel, Anice C. Lowen Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA ABSTRACT The segmented nature of the influenza virus genome allows ... See full document

... novel influenza virus of the H7N9 subtype has infected more than 350 people in China since 19 February ...2013. Evolutionary analysis indicates that the virus is a reassortant originated from ... See full document

... pathogenic virus, predicting the probability that such mutations are passed on during disease transmission to a new ...A virus as a model organism, we develop a life-history model of the within-host ... See full document

... divergent evolutionary paths from those observed in ...antigenic diversity of influenza viruses in ...avian influenza viruses into swine will also likely be influenced by other factors ... See full document

... We have also analyzed the evolutionary divergence dynamics of DENV-3 viruses. Results: The entire open reading frame (ORF) of thirteen DENV-3 isolated in Brazil (n = 9) and Paraguay (n = 4) were sequenced ... See full document

... genetic diversity than is usually recognized and that this region may even represent its place of origin although this will need to be confirmed with larger data ... See full document

... sequence diversity in the signal sequence compared to the rest of ...the evolutionary constraints shaping the evolution of the HA signal sequence remain ... See full document

... (H7N7) virus outbreak was most probably initiated by the introduction of an LPAI virus in poultry, fol- lowing multiple weeks of silent replication and spread until it was identified and authorities were ... See full document