[PDF] Top 20 Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses
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Exploiting knowledge of immune selection in HIV-1 to detect HIV-specific CD8 T-cell responses
... all HIV proteins computed in an independent subtype B infected cohort, in which there was good statistical power over a diverse array of HLA genotypes ...The specific amino acids representing the ... See full document
12
Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection
... under immune selection pressure. In the acute stage of HIV-1 and simian immunodeficiency virus infection, viral evolution within targeted epitopes has been well docu- mented (8, 13, 28, 34, ... See full document
11
Expansion of pre existing, lymph node localized CD8+ T cells during supervised treatment interruptions in chronic HIV 1 infection
... of HIV-1–specific cellular immune responses in the peripheral blood (PB) of infected ...of responses in the lymphoid tissue. This study analyzed ... See full document
8
Human Immunodeficiency Virus Type 1 Escapes from Interleukin-2-Producing CD4+ T-Cell Responses without High-Frequency Fixation of Mutations
... these CD8 ⫹ T cells. CD4 ⫹ T cells, in contrast, act primarily by providing help to CD8 ⫹ T cells or B cells after recognizing their cognate epitope pre- sented by MHC class II on ... See full document
11
Replicative Capacity of Human Immunodeficiency Virus Type 1 Transmitted from Mother to Child Is Associated with Pediatric Disease Progression Rate
... the selection of Gag CD8 ⫹ T-cell escape variants has also emerged as an important factor con- tributing to HIV control in individuals with protective alleles such as B*5703, B*27, and ... See full document
11
Investigation of the early HIV-1-specific CD8+ T cell response and the selection of escape viral variants.
... the specific response to each HIV-1 ...whole HIV-1 proteins, delivered via a recombinant vaccinia virus vector, or epitope peptides are shown (Figure ...are CD8^ T cells ... See full document
548
Differential Impact of Magnitude, Polyfunctional Capacity, and Specificity of HIV-Specific CD8+ T Cell Responses on HIV Set Point
... an immune response that re- sults in control of HIV replication is critical for designing an HIV vaccine capable of eliciting such a response ...of CD8 ⫹ gamma interferon (IFN- ␥ ) T ... See full document
6
Enhanced Anti-HIV Functional Activity Associated with Gag-Specific CD8 T-Cell Responses
... we detect distinct differences in CD8 T-cell function between individuals with chronic HIV-1 clade C in- fection, associated with the breadth and magnitude of Gag- ... See full document
10
Rapid development of HIV elite control in a patient with acute infection
... the HIV-positive popu- lation (< 1%), suppress HIV viremia below 50 copies per ml in the absence of ART ...and immune dynamics during acute infection in individuals that go on to become ... See full document
6
Enhanced PD-1 Expression by T Cells in Cerebrospinal Fluid Does Not Reflect Functional Exhaustion during Chronic Human Immunodeficiency Virus Type 1 Infection
... infections, T cells are exhausted due to constant antigen exposure and are associated with enhanced programmed death 1 (PD-1) ...death-ligand 1 (PD-L1) pathway are associated with autoimmune ... See full document
10
HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses
... of HIV-specific CD4 ⫹ T cells in the develop- ment of antibody neutralization breadth, we comprehensively as- sessed a cohort of 34 chronically HIV-infected controllers for cir- culating ex ... See full document
13
Deletion of the Vaccinia Virus N2L Gene Encoding an Inhibitor of IRF3 Improves the Immunogenicity of Modified Vaccinia Virus Ankara Expressing HIV-1 Antigens
... ⫹ T cell immune re- sponses were directed mainly against Env in both immunization ...GPN-specific CD8 ⫹ T cell im- mune responses was induced (42, 62, 63), MVA-B ... See full document
19
Immunotherapy with an HIV-DNA Vaccine in Children and Adults
... Therapeutic HIV immunization is intended to induce new HIV-specific cellular immune responses and to reduce viral load, possibly permitting extended periods without antiretroviral ...C ... See full document
19
Prevalence and Characteristics of Hepatitis B Virus (HBV) Coinfection among HIV-Positive Women in South Africa and Botswana
... among HIV-positive individu- als in sub-Saharan Africa, and its determinants remain poorly characterized ...ART-naïve HIV-positive adult women from South Africa and ...11,346 HIV-positive individuals ... See full document
11
Pathogenicity and immunogenicity of attenuated, nef deleted HIV 1 strains in vivo
... in HIV animal models have also been shown to confer complete protection against challenge infection ...a HIV vaccine, either because immunization may pose an immediate risk to individuals with weak ... See full document
13
HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses
... of HIV replication on M. tuberculosis-specific CD4 T-cell cytokine profile and ...in HIV-infected individuals, the level of PD-1 expression was increased on HIV-specific T ... See full document
18
Contribution of Virus-Like Particles to the Immunogenicity of Human Immunodeficiency Virus Type 1 Gag-Derived Vaccines in Mice
... of HIV-1 Gag VLPs in mice is complicated by the failure of HIV-1 Gag to efficiently assemble VLPs in murine ...of HIV-1 Gag. Never- theless, we consistently failed to ... See full document
12
Human adenovirus specific T cells modulate HIV specific T cell responses to an Ad5 vectored HIV 1 vaccine
... reduce T cell responses to the insert antigens; however, the impact of vector-specific cellular immunity on subse- quent insert-specific T cell responses has not ... See full document
10
Immune Activation Is Associated with CD8 T Cell Interleukin-21 Production in HIV-1-Infected Individuals
... producing CD8 T cells with CD4-like characteristics, we evaluated their ability to upregulate CD40 ligand (CD40L) upon stimula- ...IL-21-producing CD8 and CD4 T cells expressing CD40L or the ... See full document
5
Definition of the viral targets of protective HIV 1 specific T cell responses
... the responses target- ing non-beneficial OLP (Figure 5C, p = ...robust responses against both beneficial and non-beneficial ...CTL specific for the beneficial OLP(s) were up to 2 logs more effective ... See full document
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