[PDF] Top 20 Expression of an activated integrin promotes long distance sensory axon regeneration in the spinal cord
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Expression of an activated integrin promotes long distance sensory axon regeneration in the spinal cord
... 9 integrin and kindlin-1 in vitro, dissociated and explant adult DRG cul- tures were used to assess neurite ...␣9 integrin and kindlin-1, the immunostaining of eYFP was used for detecting ␣9 integrin ... See full document
15
Distinct Cis Regulatory Elements Govern the Expression of TAG1 in Embryonic Sensory Ganglia and Spinal Cord
... of spinal progenitor neurons is initiated by long-range, midline-derived, morphogens that regulate an array of transcription factors that, in turn, act sequentially or in parallel to control neuronal ...the ... See full document
12
Spinal Cord Regeneration: Ready, Set, Nogo
... showed no evidence of increased regeneration. Two explanations can possibly clear the confusion generated by these experiments. Firstly, the genetic backgrounds of the mice utilized by all three labs were not ... See full document
7
PRDX6 controls multiple sclerosis by suppressing inflammation and blood brain barrier disruption
... histopathological signs in MS lesions [12]. Astrocytes increased inducible nitric oxide synthase expression, and produce highly damaging reactive oxygen and nitrogen species[13-14]. In the present study, ... See full document
10
Effect of low-energy extracorporeal shock wave on vascular regeneration after spinal cord injury and the recovery of motor function
... a spinal cord segment (of length about 10 mm) in the SCI region without bacterial infection was ...(mRNA) expression of VEGF and its receptor ... See full document
10
Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury
... and regeneration increased in injured mice receiving ...restraining axon growth and regeneration in mammalian CNS ...α2δ2 expression parallels the increased spontaneous fir- ing of ... See full document
15
Commissural axon guidance in the developing spinal cord: from Cajal to the present day
... chicken spinal cord by controlling its inser- tion into the growth cone membrane [143] and 3) two Nedd4-interacting proteins, Ndfip1 and Ndfip2, that localize Robo1 to endosomes ...uncrossed sensory ... See full document
16
Original Article A chitosan scaffold infused with neurotrophin-3 and human umbilical cord mesenchymal stem cells suppresses inflammation and promotes functional recovery after spinal cord injury in mice
... neurotoxic. Activated microglia produce proinflammatory cytokines that induce a reactive process of secondary cell death surrounding the injury site ...treat spinal cord injuries ...the ... See full document
8
Diabetes induced microvascular complications at the level of the spinal cord: a contributing factor in diabetic neuropathic pain
... People with diabetes are susceptible to neurological disease as a result of microvascular dysfunction, impacting on motor, autonomic and cognitive systems, and increased susceptibility to stroke and dementia (Kissela et ... See full document
19
Neuroprotective effects of hyperbaric oxygen (HBO) therapy on neuronal death induced by sciatic nerve transection in rat
... through expression of apoptosis-related genes namely Bax, Bcl2, and caspase-3 [37, ...mitogen- activated protein kinas [41] in ischemic ...after spinal cord ... See full document
10
Neural progenitors in human and newt spinal cord: An in-vivo and in-vitro study
... Both urodele and human SC contain a population o f cells that can be described as ‘injury-reactive’. These cell populations respond to injury by proliferating at the damaged site and altering their expression o f ... See full document
305
Original Article Gene silencing NMII promotes axonal regeneration against contusive spinal cord injury in rats
... NMII expression has not changed significantly before and after SCI in rats, but the phosphorylated NMII level was up regulated after SCI ...following expression of phosphorylated NMII, the neuron collapse ... See full document
8
Semaphorin 6B acts as a receptor in post crossing commissural axon guidance
... commissural axon guidance more specifically by targeted electroporation of the floorplate ...Plxna1 expression disappeared from the floorplate during axonal crossing and turning, and based on biochemical ... See full document
12
Transgenic approaches to studying the development of sensory and spinal cord neurons
... is activated; the interpretation of this data is, however, difficult and the precise meaning is presently ...EGFR/rgf activated mitogenic stimulation of these cells then it is via a ra/-MAPK-independent ... See full document
230
Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain
... in spinal cord may have a role in the early estab- lishment of neuropathic pain after peripheral nerve injury ...gene expression in astrocytes, which could be prevented by SP600125, a pharmacologi- ... See full document
10
The expression and distribution of neural cell adhesion and extracellular matrix molecules after injury to, and peripheral nerve grafting into, the adult mammalian CNS
... f spinal cord m yelin proteins by SDS-PAGE identified two highly growth-inhibitory membrane protein fractions with molecular weights o f 35 kD and 250 kD, named NI- 35 and NI-250 (Caroni and Schwab, ... See full document
309
Spalt like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus
... (Fig. 7D,F), results in loss of spinal cord fate. Furthermore, the posterior defects in Sall4 morphants can be rescued via pou5f3 knockdown (Fig. 8I-K). We suggest that repression of pou5f3 via Sall4 ... See full document
11
Delayed neurologic deterioration in the patient with spinal trauma: role of MR imaging
... The aims of this study were to: 1 identify the specific spinal cord features associated with symptomatic neurologic deterioration following spinal cord injury of long-standing; 2 correla[r] ... See full document
9
Acute Disseminated Encephalomyelitis in Children
... Results. Eighteen cases were identified. Sixteen pa- tients (88%) presented in either winter or spring. Thir- teen children (72%) had a recent upper respiratory tract illness. Patients presented most often with motor ... See full document
9
Midline crossing is not required for subsequent pathfinding decisions in commissural neurons
... Since axon guidance toward the midline is a balance of attraction and repulsion, and dcc knockdown results in decreased attraction to the midline, we wanted to test whether increasing Robo-mediated repulsion would ... See full document
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