[PDF] Top 20 Gene expression profiling and histopathological characterization of triple negative/basal like breast carcinomas
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Gene expression profiling and histopathological characterization of triple negative/basal like breast carcinomas
... overall gene-expression pattern of the 'intrin- sic gene subset' when unsupervised hierarchical clustering was ...these basal-like tumors have low mRNA expression of the ER, PR ... See full document
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A clinically relevant gene signature in triple negative and basal like breast cancer
... as triple nega- tive based on the mRNA expression of ER, PgR, and HER2 as previously described ...meta- gene definition and could also weaken the power of ...primary breast cancer gene ... See full document
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Expression of P 16 ink4a in basal like triple negative breast carcinoma in Sudanese women
... Pathol 371217–26 DOI: 10.1016humpath.2006.04.015PMID: 16938528 13. Perreard L, Fan C, Quackenbush JF, Mullins M, Gauthier NP, Nelson E, Mone M, Hansen H, Buys SS, Rasmussen K, Orrico AR, Dreher D, Walters R, Parker J, Hu ... See full document
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A comprehensive morphological study for basal-like breast carcinomas with comparison to nonbasal-like carcinomas
... Background: Breast carcinomas can be classified into five subtypes based on gene expression profiling or immunohistochemical ...subtypes, basal-like breast ... See full document
11
Triple-negative breast cancer with brain metastases: a comparison between basal-like and non-basal-like biological subtypes
... view, triple-negative breast cancer remains a heterogeneous group with difficult-to- define ...subtypes. Gene expression studies have shown that ER-negative and ... See full document
7
Preliminary characterization of IL32 in basal like/triple negative compared to other types of breast cell lines and tissues
... in breast cancer cells and clinical samples in which the receptor status and diagnosis has been previously ...its expression in breast ...hyperplastic breast sample compared to normal ... See full document
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p53 Expression in Triple Negative Breast Carcinomas: Evidence of Age Related and Racial Differences
... ABSTRACT Triple negative breast carcinomas (TNBC), are defined by the absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) ...mRNA ... See full document
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Cytotoxic Activity of Sphingosine-1-Phosphate against Human Triple-negative/ Basal-like Breast Cancer
... HER negative, and low expression of proliferation genes such as Ki67 18 ...all breast cancer cases and is considered to be more aggressive than luminal A 5 ...HER2 negative with high ... See full document
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Knockdown of CAVEOLIN-1 Sensitizes Human Basal-Like Triple-Negative Breast Cancer Cells to Radiation
... suppressor gene or as a tumour promoter seems to strictly depend on cell type and tumour stage ...in breast cancer subtypes and its significance in breast carcinogenesis, we first analysed the ... See full document
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Proper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes
... BRCA1-mutated triple negative breast carcinomas which were selected for high amounts of ...genomic profiling of BRCA1-mutated breast ...genomic profiling, at least in our ... See full document
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Classification of triple-negative breast cancers based on Immunogenomic profiling
... Triple-negative breast cancer (TNBC) is a breast cancer subtype that lacks the expression of hormone receptors (estrogen receptor (ER) and progesterone receptor (PR)) and human ... See full document
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Gene expression signatures of morphologically normal breast tissue identify basal like tumors
... of gene expres- sion in morphologically normal epithelium and stroma adjacent to breast cancers as well as from reduction mammoplasty ...the gene expression profiles revealed that there are no ... See full document
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A Correlation of Pathological Characteristics and Immuno Histo Chemistry (IHC) Based Biomarker Expression in Triple Negative Breast Carcinomas
... of triple-negative breast cancer in an institutional setting (a tertiary care oncology ...a basal nature, to better comprehend the relationship between triple negative and ... See full document
10
Profiling molecular regulators of recurrence in chemorefractory triple negative breast cancers
... identified. Gene expression data from paired biopsies revealed enrichment of actionable regulators of stem cell-like behavior and depletion of immune signaling, which was corroborated by total ... See full document
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Gene expression molecular subtyping of triple negative breast cancer tumours: importance of immune response
... separated triple-negative tumours into three clusters: C1 ...of triple-negative patients were not basal-like ...pure basal-like cluster. C3, enriched in ... See full document
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A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells
... all breast cancers and only about half of these are basal-like (Leh- mann et ...in basal-like ...for basal-like TNBCs? No individual cell line can hope to recapitulate the ... See full document
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Original Article p16 expression in basal-like breast carcinoma
... invasive breast carcinomas with specific genotype and immunopro- ...by gene expression profiling and is currently associated with poor ...(ER) negative, progesterone receptor ... See full document
8
Subtyping Of Triple Negative Breast Carcinoma On The Basis Of RTK Expression
... The characterization of breast tumors using a panel of tumor-specific surrogate markers not only contributes to a better understanding of functional mechanisms involved in tumor differentiation, growth and ... See full document
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SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal like and triple negative breast cancer
... the expression and signaling activities of FGFR1 and c-Met ...for expression of both FGFR1 and ...between gene expression and protein stability, we speculate that SHP2 promotes FGFR1 and c-Met ... See full document
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Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities
... comprehensive gene expression analysis revealed extensive molecular heterogeneity within TNBC cases and identified four to six distinct molecular TNBC subtypes [4, ...unique expression signatures and ... See full document
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