[PDF] Top 20 Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): study protocol for a randomised controlled trial

... the study centre in ...mg fenofibrate or placebo, admin- istered once a day for a minimum of 2 weeks directly prior to surgery, in a parallel-group ...to fenofibrate or placebo will be stratified by ... See full document

... local study centre clinical trials pharmacist by telephone ...clinical trial pharmacist at the central medication centre will be ...local study coordinator with instructions to contact in the event ... See full document

... parallel-group, randomised, double-blind, placebo-controlled ...be randomised to either 2 g of myo-inositol or identical placebo twice daily for 12 ...infrarenal aortic volume measured on ... See full document

... placebo controlled trials which have recently been described in detail elsewhere [54, ...of fenofibrate taken daily for a minimum of 2 weeks in 42 participants scheduled for an elective open AAA ...whether ... See full document

... assessed. As would be expected from previous studies, patients allocated feno fibrate had reductions in circulating triglyceride concentrations and eGFR, and an increase in serum homocysteine. 16 Similarly, patients ... See full document

... The DSMB will consist of an independent epidemiolo- gist, vascular surgeon and statistician; and will meet to assess all adverse events. In particular, the DSMB will concentrate on AAA-related events such as sudden death ... See full document

... this study straddles specialties, particularly car- diology and vascular surgery, an extensive collaborative approach has been employed to the benefit of the study design and patient ... See full document

... We believe that a programme of research is needed now to evaluate the bene fi ts of pre-operative exercise training in patients undergoing elective non- cardiothoracic surgery. Abdominal aortic ... See full document

... The aneurysm detection and management study screening program: Validation cohort and final ...results. Aneurysm detection and management veterans affairs cooperative study ... See full document

... abdominal aortic aneurysm. EVAR devices are constantly being improved and sizing and imaging methods available for deployment are better now than they were between 1999 and 2004: a corollary is that ... See full document

... The primary outcome will be change from baseline in the National Institute of Health Chronic Prostatitis Symptom Index, a validated instrument for the assessment of men with chronic prostatitis. Secondary outcomes ... See full document

... with abdominal aortic aneurysm was performed twice, the first time before the surgery and the second time on the seventh day after the ...all study groups with different physiotherapy models ... See full document

... 1:1 randomised controlled trial comparing two suture techniques for the closure of the midline abdominal wound following surgery for colorectal ...be randomised from approximately 20 ... See full document

... patient management, re- source use and the potential impact on the population is substantial, given that aspirin is widely ...The study will also provide the opportunity to systematically review the safety ... See full document

... patient management, re- source use and the potential impact on the population is substantial, given that aspirin is widely ...The study will also provide the opportunity to systematically review the safety ... See full document

... our study, as we did not know the inflammatory biomarker levels that may result from this surgery, nor what difference to expect in the intervention and control groups based on our ... See full document

... multicentre randomised controlled trial (RCT) would be best placed to investigate the hypothesis that treatment with the n-bisphosphonate ZA, in addition to the standard chemotherapy (pemetrexed and ... See full document

... present study a decrease in plasma adhesion molecules was ...intra-operative management could be potential mechanism for the reduction in soluble adhesion molecules as well as the lack of increase in serum ... See full document

... the goal of reaching heart rates > 90% of HRmax with al- ternating ‘rest’ intervals of lower intensity cycling lasting 1 min at heart rates of ≥ 60% maximum heart rate. The duration of intense exercise intervals will ... See full document

... the study was ...maintain study mo- mentum and recruitment procedures and not disrupt the logistics of the ...this study as it was not powered for compara- tive analysis. Any future trial ... See full document