[PDF] Top 20 Hematopoietic Stem Cells, Stem Cell Processing, and Transplantation

... A) Additional chemotherapy to induce remission B) Syngeneic bone marrow transplantation C) Allogeneic sibling bone marrow transplantation D) Unrelated donor bone marrow transplantation E[r] ... See full document

... the cell-dose barrier, including ex-vivo expansion of UCB stem cells, intraosseous infusion of UCB cells, activating homing receptors (such as CXCR4), and use of double cord blood units ...of ... See full document

... of hematopoietic stem cells (HSC), supporting their survival and proliferation in ...following transplantation, we transplanted normal marrow cells into lethally irradiated Tpo –/– and ... See full document

... Allogeneic hematopoietic stem cell transplantation (AHSCT) is an intention-to-cure treatment strategy in several malignancies and nonmalignan- ...transplanted hematopoietic stem ... See full document

... B cells; CB: cord blood; cGVHD: chronic GVHD; CMV: cytomegalovirus; CR: complete response; DCs: dendritic cells; EF: engraftment failure; GVHD: graft-versus-host disease; HGF: hepatocyte growth factor; ... See full document

... Hematopoietic stem-cell transplantation (HSCT) refers to a procedure in which hematopoietic stem cells are infused to restore bone marrow function in cancer patients who ... See full document

... adult stem cells, mes- enchymal stem cells (MSCs) are non-hematopoietic stem cells originally isolated from bone marrow ...marrow hematopoietic microenviron- ment ... See full document

... Briefly, hematopoietic stem cells were mobilized with cyclophosphamide ...The cells were injected intravenously after conditioning with cyclophosphamide (200 mg/kg) and rabbit antithymocyte ... See full document

... 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, ... See full document

... modified hematopoietic stem cells as a potentially curative treatment for HIV ...transduced stem cells have no intrinsic selective advantage compared with untransduced host ... See full document

... The patient was readmitted for persistent high fever and cough on day 73 post-transplantation. Chest computed tomo- graphy (CT) scans suggested mild pneumonia without severe pulmonary lesions (Figure 1A). Despite ... See full document

... Human stem cell models (CD34+ hematopoietic progenitors, embryonic stem cells and induced pluripotent stem cells (iPSCs)) are powerful tools for the study of ... See full document

... and transplantation modalities, specifically conditioning regi- men (chemotherapy, total body irradiation (TBI)) and graft-versus-host disease (GVHD) prophylaxis (immuno- suppression, steroids), influence the ... See full document

... ES cells (112). Also, some types of iPSC-derived neural cells have an increased likelihood of tumor formation after transplantation into the ...contrast, transplantation of “unsafe” ... See full document

... primary induction failure or with relapsed FL were treated with myeloablative therapy followed by transplantation of purged autologous bone marrow or PBSC. The four-year estimate of OS was 60% and of DFS was 44% ... See full document

... allogeneic hematopoietic stem cell trans- plantation have significantly reduced the morbidity and mortality associated with this ...gene-modified hematopoietic stem cell ... See full document

... progenitor cell targeted CNT-20 ...the cell membranes with weak cytoplasmic expression, but minimal expression was observed in the SHEM ...genitor cell targeted CNT-20 medium were negative for the ... See full document

... A cell-based therapeutic approach, using mesenchymal stem cells (MSCs), has recently shown considerable promise because of their expected immunomodulatory effects [11, ...fibroblast-like cells ... See full document

... resident stem cells. Adult stem cells are characterized by the ability to self-renew and differentiate into multiple cell types within a ...that stem cells are nonetheless ... See full document

... allogeneic hematopoietic stem cell transplantation (HSCT) was ...with cells from a second matched unrelated donor and after conditioning with fludarabine, thio- tepa, alemtuzumab, and ... See full document