[PDF] Top 20 Hepatitis B Virus X Protein Function Requires Zinc Binding
Has 10000 "Hepatitis B Virus X Protein Function Requires Zinc Binding" found on our website. Below are the top 20 most common "Hepatitis B Virus X Protein Function Requires Zinc Binding".
Hepatitis B Virus X Protein Function Requires Zinc Binding
... USA b Department of Chemistry, Washington University, ...suppresses hepatitis B virus (HBV) ...the X protein (HBx), which redirects the cellular DNA damage-binding pro- ... See full document
18
Turnover of Hepatitis B Virus X Protein Is Regulated by Damaged DNA-Binding Complex
... with X to import the two proteins into the nucleus and that once in the nucleus, X is retained in this compartment via its interaction with ...the X protein plays a role in X ... See full document
7
DDB2 Induces Nuclear Accumulation of the Hepatitis B Virus X Protein Independently of Binding to DDB1
... Because HBV is a liver pathogen, we examined nuclear expression of the DDB subunits in mouse livers. The expres- sion studies indicated that the nuclear levels of DDB1 and DDB2 are quite low in resting liver cells. Upon ... See full document
10
Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication
... HBx protein expression was appreciable and easily detectable in the cytoplasm of cells transfected with an amount of HBx expression plasmid that achieved activation of tran- scription through the AP-1 ...HBx ... See full document
7
Role of Polypyrimidine Tract Binding Protein in the Function of the Hepatitis B Virus Posttranscriptional Regulatory Element
... PTB binding in PRE function. The binding of PTB to fragment III does not necessarily reflect a role for PTB in PRE ...PTB binding, we performed two sets of ...PTB binding on PRE func- ... See full document
8
Protein-x of hepatitis B virus in interaction with CCAAT/enhancer-binding protein α (C/EBPα) - an in silico analysis approach
... Experimentally, protein-x has defied x-ray crystallography and nuclear magnetic reso- nance ...the protein is available, determination of the secondary structure and tertiary structures of ... See full document
10
Hepatitis B Virus X Protein Interferes with Cellular DNA Repair
... inhibitory function of ...UVDDB binding is not required for HBx-induced inhibition of DNA ...the binding studies were performed in yeast and utilized a GAL4 fusion protein, while the repair ... See full document
7
Hepatitis B Virus X Protein and Simian Virus 5 V Protein Exhibit Similar UV-DDB1 Binding Properties To Mediate Distinct Activities
... activity protein (UV-DDB) consists of two subunits, DDB1 and DDB2, and functions in DNA repair and cell cycle ...the hepatitis B virus X protein (HBx). Binding of HBx to ... See full document
10
The NS5A Protein of Bovine Viral Diarrhea Virus Contains an Essential Zinc-Binding Site Similar to That of the Hepatitis C Virus NS5A Protein
... the zinc-binding properties of the BVDV NS5A protein on the basis of se- quence analysis and atomic absorption spectroscopy of par- tially purified ...this zinc-binding site has been ... See full document
9
Hepatitis B Virus X Protein Is both a Substrate and a Potential Inhibitor of the Proteasome Complex
... Inhibition of protease activities of proteasome by HBX. Since HBX binds to proteasomes and the transactivation by HBX requires proteasome function, we further investigated whether the interaction of HBX ... See full document
10
Ebola Virus Transcription Activator VP30 Is a Zinc-Binding Protein
... the zinc-binding do- main of the full-length protein resulted in a complete loss of the transactivating function of VP30 during transcription, pointing to the importance of the integrity of ... See full document
5
Hepatitis B virus X protein interacts with β5 subunit of heterotrimeric guanine nucleotide binding protein
... The pBIND-GNβ5 plasmid was transfected together with the pACT-HBX plasmid and the pG5luc luciferase vector to test the protein-protein interaction between partial GNβ5 sequence and full-length HBX in the ... See full document
8
A transcription initiation site for the hepatitis B virus X gene is directed by the promoter-binding protein.
... In contrast, the similar mutations introduced into this target sequence for X-PBP binding failed to shift the transcription start site of the CAT construct, in which the X promoter regio[r] ... See full document
7
Hepatitis B virus X protein and endoplasmic reticulum stress
... 同时引起增强子结合蛋白同源蛋白(C/E B P- homologous protein, CHOP)表达量上调 [20] . 激 活的IRE1能从X盒结合蛋白1(XBP-1)mRNA 中特异性剪切26个碱基的内含子, 使翻译产物 XBP-1促进GRP78表达, 以减轻或中止ER应激 ... See full document
8
Hepatitis B Virus X Protein Induces Hepatic Steatosis by Enhancing the Expression of Liver Fatty Acid Binding Protein
... ABSTRACT Hepatitis B virus (HBV) has been implicated as a potential trigger of hepatic steatosis although molecular mechanisms involved in the pathogenesis of HBV-associated hepatic steatosis still ... See full document
12
Mapping of B-cell epitopes of the human hepatitis B virus X protein.
... Fusion protein 16 reacted only rarely in immunoblotting (although it contains 16 carboxy-terminal HBx-specific amino acids), whereas peptide 15 containing the same HBx sequence minus two[r] ... See full document
8
Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice.
... Tissue preferential expression of the hepatitis B virus (HBV) surface antigen gene in two lines of HBV transgenic mice. Multiple tissues express[r] ... See full document
9
The anti-resection activity of the X protein encoded by Hepatitis Virus B
... Accepted Article HBx, this additional binding is likely to be disrupted, leading to the dissociation of WDR70 from the CRL4 scaffold. Our data establishes a functional link between HBx and CRL4-mediated DNA end ... See full document
37
Deregulation of Epigenetic Mechanisms by the Hepatitis B Virus X Protein in Hepatocarcinogenesis
... The consequence of chronic HBV infection and continued expression of X, mediating down-regulation of these proteins through each cell cycle of an HBV infected hepatocyte, for many cell generations, is not yet ... See full document
16
trans-activation of viral enhancers by the hepatitis B virus X protein.
... By cotransfecting pSV2cat and the X gene with a plasmid containing either the intact SV40 genome, the SV40 genome devoid of the T-antigen (T-ag) gene, or only the T-ag gene, we demonstra[r] ... See full document
8
Related subjects