[PDF] Top 20 Herpes Simplex Virus Type 1 Evades the Effects of Antibody and Complement In Vivo

... Herpes simplex virus type 1 (HSV-1) encodes a complement-interacting glycoprotein, gC, and an immuno- globulin G (IgG) Fc binding glycoprotein, gE, that mediate immune ... See full document

... as complement activation, antibody-dependent cellular cytotoxicity, or complement-dependent cellular cyto- toxicity, are inhibited by the HSV-1 ...that virus neutralization in the ... See full document

... the effects of Us3 phosphorylation of gB Thr-887, includ- ing regulation of proper cell surface expression of gB and promotion of nuclear egress of nucleocapsids, are probably critical for HSV-1 replication ... See full document

... gC-null virus did not result in vaginal titers comparable to those for rescued ...the complement cascade, since our previous results indicate that gC blocks C5 and properdin involvement in complement ... See full document

... induce virus reactivation from the latent ...infectious virus is produced in latently infected ganglia when explanted in vitro ...latent virus in most neurons does not exit the latent state following ... See full document

... for virus antigens with a polyclonal ...monoclonal antibody clone ...monoclonal antibody to IL-6 was obtained from Cambridge Bioscience; the monoclonal antibodies to IL-2, IL-10, and IFN-g were from ... See full document

... Sera characterized as HSV type 1 HSV-1 or HSV-2 positive or negative by MN were selected and tested by CF, and those with discordant results were further analyzed for specific antibodies[r] ... See full document

... and complement may interfere with the initial stages of virus infection through several mechanisms, including coating virus to prevent attachment, fusion, and entry into host cells, or inducing ... See full document

... simiae and herpes simplex in monkeys, the results of our CF tests with monkey sera relate well to those with the human case in that the CF titers were highest with crude antigen of the s[r] ... See full document

... ment-enhanced antibody neutralization than the rescue strain, indicating that the HSV-1 Fc ␥ R is not blocking complement activation by the Fc domain of human IgG antibody to ... See full document

... The correlation between the amount of HSV latency and the frequency of reactivation both in vitro and in vivo has been examined by a number of investigators. In these studies, la- tency was quantified on the basis ... See full document

... 3 Thermolabile In Vivo DNA-Binding Activity Associated with a Protein Encoded by Mutants of Herpes Simplex Virus Type 1 Received 30 December 1982/Accepted 17 March 1983 The major DNA-bin[r] ... See full document

... * 857 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Neuraminidase treatment of cells infected with herpes simplex virus type 1 HSV-1 markedly enhanced the binding of [r] ... See full document

... Effect of endo H on newly synthesized and immunoprecipitation with anti-gF-2 111188 processed forms of gF-2 immunoprecipitated monoclonal antibody followed by preparative anti-gF-2 III18[r] ... See full document

... tious virus assays were performed as previously ...infectious virus in 5 (31%) of 16 ocular swabs and in 6 (75%) of 8 TG from the surviving mice (Table 3) and yielded only one ... See full document

... leukemia virus reverse transcriptase in a 40- m l total ...with 1 m g of ethidium bromide per ml, viewed with a transilluminator, and then photographed using Polaroid 665 instant ... See full document

... Analysis of the potential coding sequences within the 2.9-kb Sall DNA fragment of HSV-2 revealed an open reading frame of 479 amino acids which began with the methionine encoded at posit[r] ... See full document

... s 1 gene ...ICP22-minus virus, d22:GFP. The bands reactive with antibody 413 migrated in a manner similar to that of those detected in KOS-infected samples ...null virus, ... See full document

... using an anti-ICP8 antibody (Fig. 4B). It appears very clearly that in cells transfected with nucleolin siRNAs, the ICP8 stain- ing was restricted to the small numbers of cells that have not been transfected by ... See full document

... a virus in this study, whose L-S junctions lacked a sequences and yet still promoted normal L and S component inversion, as well as a previously characterized HSV-1 mutant whose L-S junctions had under- ... See full document