[PDF] Top 20 Herpes Simplex Virus Type 1 ICP27-Dependent Activation of NF-κB
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Herpes Simplex Virus Type 1 ICP27-Dependent Activation of NF-κB
... for activation of the NF- B ...to virus binding and entry should occur normally and allow us to de- termine if any of these early events in the viral life cycle are important in the ... See full document
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Processing of α-Globin and ICP0 mRNA in Cells Infected with Herpes Simplex Virus Type 1 ICP27 Mutants
... of ICP27 on accumulation of transcripts that retain ICP0 intron ...intron 1 sequence have not been reported previously, and although it is possible that they are HeLa cell specific, it is more probable that ... See full document
13
Association of Herpes Simplex Virus Type 1 ICP8 and ICP27 Proteins with Cellular RNA Polymerase II Holoenzyme
... of activation, which contains mainly SRB proteins and other general transcription factors, may exist as separate identities or may tightly associate with the CTD of Pol II large subunit in the core enzyme ... See full document
12
Type I Interferon and NF-κB Activation Elicited by Herpes Simplex Virus gH/gL via αvβ3 Integrin in Epithelial and Neuronal Cell Lines
... to activation of the cytosolic sen- sors, whereas the TLRs located at the plasma membrane elicit a predominantly inflammatory response ...against herpes simplex virus (HSV) and other ... See full document
6
Activation of NF-κB in CD8+ Dendritic Cells Ex Vivo by the γ134.5 Null Mutant Correlates with Immunity against Herpes Simplex Virus 1
... wild-type HSV-1(F) and reduced viral replication in the brain (Fig. 1A and B). Compared to the mock-vaccinated control, no vaccinated mice displayed signs of encephalitis over a 21-day pe- riod. To explore ... See full document
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Cells Lacking NF-κB or in Which NF-κB Is Not Activated Vary with Respect to Ability To Sustain Herpes Simplex Virus 1 Replication and Are Not Susceptible to Apoptosis Induced by a Replication-Incompetent Mutant Virus
... and 1⫻ Taqman universal master ...min, activation of AmpliTaq Gold DNA polymerase at 95°C for 10 min, followed by 40 cycles of denaturation at 95°C for 15 s, and a combined annealing-extension step at 60°C ... See full document
7
Identification of an ICP27-Responsive Element in the Coding Region of a Herpes Simplex Virus Type 1 Late Gene
... then ICP27’s appar- ent ability to enhance mRNA accumulation from the UL42-SE gene may simply reflect the disruption of the putative UL42 inhibitory ...the ICP27-inde- pendent expression of gC in a d27 ⌬ CA ... See full document
12
The Virion Host Shutoff Protein of Herpes Simplex Virus 1 Blocks the Replication-Independent Activation of NF-κB in Dendritic Cells in the Absence of Type I Interferon Signaling
... certain proinflammatory genes. If vhs had an affinity for these mRNA molecules (with respect to nuclease-driven degrada- tion), the nature of what drives their expression would pre- sumably be irrelevant, and there would ... See full document
11
Identification of an Export Control Sequence and a Requirement for the KH Domains in ICP27 from Herpes Simplex Virus Type 1
... The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an RNA-binding protein that performs multiple functions required for the expression of ... See full document
10
Functional Comparison of Herpes Simplex Virus 1 (HSV-1) and HSV-2 ICP27 Homologs Reveals a Role for ICP27 in Virion Release
... the ICP27 gene family appear to have diverged over time, as the ICP27 homologs from HCMV (51), varicella-zoster virus (52, 53), and pseudora- bies virus (54) are completely unable to ... See full document
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Arginine Methylation of the ICP27 RGG Box Regulates ICP27 Export and Is Required for Efficient Herpes Simplex Virus 1 Replication
... when ICP27 was hypomethylated, in con- trast to what has been seen in yeast for the proteins Npl3 and Hrp1, which become confined to the ...with ICP27, but it might be due to the effect of hypomethylation ... See full document
12
DNA-Dependent Oligomerization of Herpes Simplex Virus Type 1 Regulatory Protein ICP4
... human herpes simplex virus type 1 regulatory protein ICP4 binds DNA as a dimer and forms a single protein-DNA complex (A complex) with short DNA ... See full document
8
AKT1-Dependent Activation of NF-κB by the L Protein of Parainfluenza Virus 5
... that NF- B is activated in rPIV5V ⌬ C-infected cells (18, ...of NF- B activa- tion, we examined the ability of viral protein expression to activate NF- B-dependent reporter gene ...three ... See full document
9
Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 Protein Inhibits Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Interacting with p65/RelA and p50/NF-κB1
... host NF-B innate immune response is quite complex, and it is well known that the classical NF- B pathway is significantly acti- vated upon HSV-1 infections (66, 67) and was shown to be involved in ... See full document
14
Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.
... of ICP27 concentration during infection, Vero cells were infected with n208, n18, n215, or d2, at multiplicities of infection of ...The ICP27 deletion mutant virus, ...multiplicity- dependent ... See full document
11
The Herpes Simplex Virus Type 1 Regulatory Protein ICP27 Is Required for the Prevention of Apoptosis in Infected Human Cells
... ment with the inhibitor. Our results showing that we did not observe cell morphological changes or DNA laddering in the presence of CHX seem to support this theory. Additional sup- port for this model comes from the ... See full document
11
Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-κB Activation
... FIG 1 UL24 inhibits the activation of the IFN-  and IL-6 promoter induced by cGAS-STING and ISD-mediated production of IFN-  and ...fold activation was determined compared to the empty ... See full document
10
Herpes Simplex Virus ICP27 Activation of Stress Kinases JNK and p38
... IE ICP27 or DE ...detectable activation of JNK was observed in the lysates from mock-infected, UV-irradiated virus or KOS infec- tion at the residual MOI (lanes 1 to 3), while the lysate from ... See full document
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UL31 of Herpes Simplex Virus 1 Is Necessary for Optimal NF-κB Activation and Expression of Viral Gene Products
... of NF- B activity by the drug resveratrol results in reduced levels of several ␣ gene mRNAs and undetectable levels of gC mRNA (6), we hypothesized that pU L 31 might augment viral protein expres- sion by ... See full document
7
Herpes Simplex Virus 1 Protein Kinase US3 Hyperphosphorylates p65/RelA and Dampens NF-κB Activation
... US3 prevents nuclear translocation of p65. Nuclear translo- cation of p65 is crucial for the transcription of NF-B. We hypoth- esized that hyperphosphorylation of p65 by US3 might abrogate the nuclear trafficking ... See full document
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