[PDF] Top 20 Host Factors in Coronavirus Replication
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Host Factors in Coronavirus Replication
... regarding coronavirus-induced double-membrane structures is the possible involvement of the autophagy pathway, which derives from the fact that autophagosomes also have double ...their replication (de Haan ... See full document
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A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins
... identify host factors relevant for severe acute respiratory syndrome-coronavirus (SARS-CoV) replication, we performed a small interfering RNA (siRNA) library screen targeting the human ...on ... See full document
16
Host Protein Interactions with the 3′ End of Bovine Coronavirus RNA and the Requirement of the Poly(A) Tail for Coronavirus Defective Genome Replication
... The coronavirus genome is capped at the 5 ⴕ end and has a 3 ⴕ UTR that consists of 300 to 500 nucleotides (nt) plus a poly(A) ...of coronavirus replication, we have begun to examine the involvement ... See full document
13
Middle East respiratory syndrome coronavirus infection: virus host cell interactions and implications on pathogenesis
... replication, as well as the occurrence of infection- induced apoptosis in human lung tissue [24]. Moreover, it was shown that MERS-CoV infection in ex vivo lung tissues displayed the comparable extent and kinetics ... See full document
7
Comparative Host Gene Transcription by Microarray Analysis Early after Infection of the Huh7 Cell Line by Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus 229E
... viral replication was measured by reverse transcription-quantitative PCR (RT-qPCR) on the culture ...of coronavirus antigen expres- sion in infected cells was measured by indirect immunofluorescence with ... See full document
14
Binding of Avian Coronavirus Spike Proteins to Host Factors Reflects Virus Tropism and Pathogenicity
... the host, we took a similar approach by cloning the codon-optimized sequence of the S1 gene of the virulent Massachusetts reference strain M41 (14) into a pCD5 expression vector, where it was preceded by the CD5 ... See full document
10
Identification of Host Cell Factors Associated with Astrovirus Replication in Caco-2 Cells
... RNA replication occurs in association with ...with host cell membranes using free-flow zonal electrophoresis (FFZE), a versatile technique that allows the separation of membranes on the basis of the net ... See full document
12
Crystal Structure of the Superfamily 1 Helicase from Tomato Mosaic Virus
... the host factors involved in viral- RNA replication vary from one virus to another (23, 25, 38), and because TOM1 and ARL8 are specifically required for RNA repli- cation of ToMV and related viruses ... See full document
12
Host Cell S Phase Restricts Legionella pneumophila Intracellular Replication by Destabilizing the Membrane Bound Replication Compartment
... melanogaster host factors that modulate Legionella pneu- mophila intracellular ...identify host factors that either contribute to or interfere with intracellular replication ... See full document
18
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation
... genome replication but likely act as immune antagonists that may be critical for pathogenesis ...syndrome coronavirus (SARS- CoV) ORF3a-encoded proteins (20, 21) the only known corona- virus proteins thus ... See full document
12
Participation of both Host and Virus Factors in Induction of Severe Acute Respiratory Syndrome (SARS) in F344 Rats Infected with SARS Coronavirus
... Virus titers increased significantly (P ⬍ 0.05) in nasal and lung washes and in maxillar and lung homogenates of strain F-ratX-VeroE6-infected young rats on days 3 and 5 p.i. com- pared with strain Frankfurt 1-infected ... See full document
10
Suppression of feline coronavirus replication in vitro by cyclosporin A
... genomic replication and transcription of several viruses ...cellular factors with high affinity for CsA [12] and comprise a family of cellular peptidyl-prolyl cis-trans isomerases (PPIases) that catalyze ... See full document
7
Cell Host Response to Infection with Novel Human Coronavirus EMC Predicts Potential Antivirals and Important Differences with SARS Coronavirus
... the host response and impact viral replication/patho- ...the replication of influenza virus (38), vaccinia virus (39), and HCMV ...other host-targeting molecules, like peroxisome ... See full document
11
Murine Cytomegalovirus (CMV) M33 and Human CMV US28 Receptors Exhibit Similar Constitutive Signaling Activities
... many host cell proteins, including DNA replica- tion enzymes and transcription factors, which are necessary for both viral gene expression and viral DNA ... See full document
8
Network Guided Discovery of Influenza Virus Replication Host Factors
... and host protein interaction data can be integrated to improve large-scale drug target discovery (specifically antiviral target discovery) and reveal additional insights into virus-host ...important ... See full document
14
Host factors involved in chikungunya virus replication
... individual host and the specific tissue source (serum) from which it was ...for replication in both arthropod and vertebrate hosts ...by host alternation ...of replication kinetics, vector ... See full document
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In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex Associated Proteins
... found a significant ⬎ 25-fold (Fig. 3A) increase in sgRNA packaging. This decrease in selective packaging may reflect requirements for the primary sequence of the P/S stem, proper secondary structure, or a combination of ... See full document
14
Host Factors in Enterovirus 71 Replication
... the replication of many viruses, such as murine hepatitis virus, hepatitis C virus, dengue virus, vesicular stomatitis virus, Sindbis virus, human papillomavirus 16, and human cytomegalovirus (17, 31, 41, 53, 66, ... See full document
9
Dynamics of Coronavirus Replication-Transcription Complexes
... viral replication complexes along microtubule tracks has been documented for several viruses, the dynamics of these structures has so far been reported in detail only for HCV (74) and vaccinia virus ...(late), ... See full document
16
Receptor Utilization and Antiviral CD8 T Cell Responses during Central Nervous System Infection with a Murine Coronavirus
... in replication to the murine olfactory bulbs, contains three amino acid substitutions within HR1 that have been associated with the requirement for low pH to induce ... See full document
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