[PDF] Top 20 Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Enhances Expression from Unintegrated HIV-1 DNA
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Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Enhances Expression from Unintegrated HIV-1 DNA
... whether Vpr was increasing expression by facilitating nuclear import of inte- grase-defective ...HIV-1. Vpr is critical in the infection of non- dividing cells but not of dividing ... See full document
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Human Immunodeficiency Virus Type 1 Vpr Induces the Degradation of the UNG and SMUG Uracil-DNA Glycosylases
... The Vpr-induced reduction in intracellular UNG was more pronounced when Vpr was expressed alone than in the context of the virus ...when Vpr was produced in the context of the virus ... See full document
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Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers.
... derived from the construct LTRNef by PCR mutagenesis ...(to DNA sequence ATGGAAACTAGT; amino acid sequence Met-Glu-Thr-Ser) surrounding the Nef initiation codon (bold) to create an SpeI site (underlined) ... See full document
7
Human Immunodeficiency Virus Type 1 Vpr Interacts with Antiapoptotic Mitochondrial Protein HAX-1
... synthetic HIV-1 Vpr peptide to study its interaction with isolated mitochondria in ...of Vpr, these authors observed rapid dissipa- tion of MMP; this change in potential correlated with a ... See full document
12
Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis in Human Neuronal Cells
... both Vpr and gp120 treatments ...of 1 ng/ml, only a few labeled nuclei of neurons were detected with both of these proteins, as deter- mined by a comparison of the TUNEL staining and the phase- contrast ... See full document
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Human Immunodeficiency Virus Type 1 Vpr Protein Does Not Modulate Surface Expression of the CD4 Receptor
... of Vpr expression achieved in electrotransformed cells were not sufficient to downmodulate the viral receptor, we analyzed Jurkat-T-high CD4 ...simian virus 40, which enhances transcriptional ... See full document
6
The Interaction of Vpr with Uracil DNA Glycosylase Modulates the Human Immunodeficiency Virus Type 1 In Vivo Mutation Rate
... of Vpr and UNG incorporation into HIV-1 ...of Vpr and UNG was analyzed using a packaging assay in which Vpr and UNG were expressed in trans and incorporated into virions ...The ... See full document
9
Interactions between human immunodeficiency virus (HIV) 1 Vpr expression and innate immunity influence neurovirulence
... of HIV disease progression in a cohort of AIDS patients regarding the role of a comparatively unstudied viral protein found in the ...different HIV-1 ...Δ Vpr-77R-ND peptide, whereas as it was ... See full document
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Impairment of Human Immunodeficiency Virus Type 1 (HIV-1) Entry into Jurkat T Cells by Constitutive Expression of the HIV-1 Vpr Protein: Role of CD4 Down-Modulation
... The human immunodeficiency virus type 1 (HIV-1) Vpr accessory gene product is a small virion-associated protein (15 kDa) that localizes in the nucleus of infected ... See full document
5
Fate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vpr.
... of human immunodeficiency virus type 1 (HIV-1) viral DNA in infected peripheral blood lymphocytes and immortalized T-cell lines by using a replication-defective ... See full document
7
Human Immunodeficiency Virus Type 1 (HIV-1) Viral Protein R (Vpr) Interacts with Lys-tRNA Synthetase: Implications for Priming of HIV-1 Reverse Transcription
... received from Colin Goding (Marie Curie Research Institute, Oxted, United Kingdom) and Stephen Elledge (Baylor College of Medicine, Houston, ...the HIV-1 LAI vpr gene from the BamHI ... See full document
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Nuclear Export of Human Immunodeficiency Virus Type 1 Vpr Is Not Required for Virion Packaging
... that Vpr accumu- lated in cytoplasmic membrane-containing fractions with an efficiency that closely matched that seen for the wild-type virus ...of Vpr in the cytoplasm of ... See full document
5
Human Immunodeficiency Virus Type 1 Vpr Links Proteasomal Degradation and Checkpoint Activation
... of HIV-1 ...The Vpr-UPS model predicts the interaction of Vpr with DCAF1 and a putative degradation substrate, ...with Vpr. For simplicity, we have represented Vpr interacting ... See full document
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Transdominant Activity of Human Immunodeficiency Virus Type 1 Vpr with a Mutation at Residue R73
... FIG. 1. Transcriptional activity of Vpr and its mutant ...wild-type Vpr depicting the areas representing helical domains I and II and the leucine-rich ...R73A) Vpr upon the ... See full document
5
Proline 35 of Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Regulates the Integrity of the N-Terminal Helix and the Incorporation of Vpr into Virus Particles and Supports the Replication of R5-Tropic HIV-1 in Human Lymphoid Tissue Ex Vivo
... Since Vpr expression driven by the subgenomic HIV-1 vector pNLenv1 is too low for unambiguous quantification of Vpr in cell extracts, HeLa cells were cotransfected with a vpr- ... See full document
5
Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis through Caspase Activation
... One HIV-1 accessory gene encodes a 96-amino-acid protein termed ...the HIV-1 virion has demonstrated that Vpr is found associated with the viral particle through an association with the ... See full document
7
Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex
... for HIV-1 ...with DNA repair, uracil DNA glycosylase (UNG) (68) and a human homolog of the ...with HIV-1 ...of DNA synthesis or, alternatively, could participate in ... See full document
10
Blockade of Human Immunodeficiency Virus Type 1 Expression by Caveolin-1
... Simian virus 40 enters cells via caveolae (3, 46), and evidence exists that both human immunodeficiency virus type 1 (HIV-1) (2, 41, 44, 54) and measles ... See full document
13
Human Immunodeficiency Virus Type 1 Vpr Modulates Cellular Expression of UNG2 via a Negative Transcriptional Effect
... detected from the WB analysis of HeLa-CD4 infected cells using anti- Vpr antibody to detect both HA-Vpr and native Vpr in trans- fected and infected cells, respectively (data not ...FIG. ... See full document
8
Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme.
... recombinant HIV-1 Nef protein (5) was used as an irrelevant protein in the binding ...uracil DNA gly- cosylase inhibitor (UGI; New England Biolabs) was incubated for 10 min with ... See full document
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