[PDF] Top 20 Identification and characterization of the hamster polyomavirus middle T antigen.
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Identification and characterization of the hamster polyomavirus middle T antigen.
... We reasoned that such an analysis would perhaps also greatly facilitate the mapping of the binding sites for tyrosine kinase and phosphatase on MomT for example, by comparing the ability[r] ... See full document
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Characterization of T Antigens, Including Middle T and Alternative T, Expressed by the Human Polyomavirus Associated with Trichodysplasia Spinulosa
... The polyomavirus tumor (T) antigens play crucial roles in viral replication, transcription, and cellular ...The T expression pattern of the trichodysplasia spinulosa-associated polyomavirus ... See full document
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Functional interaction between the SH2 domain of Fyn and tyrosine 324 of hamster polyomavirus middle-T antigen.
... Middle-T antigen of mouse polyomavirus (MomT) associates with the cellular tyrosine kinases c-Src, c-Yes, and Fyn, while middle-T antigen of hamster ... See full document
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Polyomavirus middle-T antigen associates with the kinase domain of Src-related tyrosine kinases.
... with middle-T (10) suggests that mid- dle-T may bind to a region close to the carboxy terminus of this ...bind middle-T indicates that c-Src sequences located amino terminal to position ... See full document
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Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.
... small t and middle T antigens (ST and MT, respectively) of ...ST-MT-large T antigen common region did not affect PP2A binding to ... See full document
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Identification of the threonine phosphorylation sites on the polyomavirus major capsid protein VP1: relationship to the activity of middle T antigen.
... DNA sequence analysis of these mutant viruses recovered from A31 cell lysates showed that the mutation at residue T-156 reverted to the wild type, but the second change at residue T-63 w[r] ... See full document
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Characterization of middle T antigen expressed by using an adenovirus expression system.
... This work demonstrates that middle T antigen produced in Ad5pymT-infected 293 human cells is qualitatively identical to that from polyomavirus-infected mouse cells.. Moreover, the behavi[r] ... See full document
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Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase.
... Furthermore, we detected protein kinase activity in PP2A immunoprecipitates and protein phosphatase activity in src immune complexes from extracts of middle T-antigen-transformed, but no[r] ... See full document
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A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling
... The most telling result is that E349K MT does not elevate the level of PIP3 in cells in the same way as the wild type (Fig. 9). This was confirmed by immunofluorescence of wild-type and MT-expressing cells (not shown). The ... See full document
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The N terminus of hamster polyomavirus middle T antigen carries a determinant for specific activation of p59c-Fyn.
... by middle T antigen, a membrane-bound protein that does not carry an intrinsic enzymatic activity but interacts and subverts the activity of cellular regulators of ...murine polyomavirus (Py) ... See full document
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Polyomavirus Middle T-Antigen Is a Transmembrane Protein That Binds Signaling Proteins in Discrete Subcellular Membrane Sites
... how polyomavirus MT inserts into membranes and the role of subcellular distribution in cell ...binding. Characterization of a number of different mutants demon- strates that the plasma membrane-located MT ... See full document
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Evidence of a Role for Phosphatidylinositol 3-Kinase Activation in the Blocking of Apoptosis by Polyomavirus Middle T Antigen
... large T antigen in simian virus 40 (SV40) (17) bind Rb and/or p300 and lead to upregulation of p53, which is thought to trigger apoptosis in virus-infected ...which polyomavirus interacts with ... See full document
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Transformation and tumorigenic properties of a mutant polyomavirus containing a middle T antigen defective in Shc binding.
... that middle T antigen is sufficient to induce full transformation in established cell lines (44, 55), while large T antigen is necessary for immortalization of pri- mary cells (23, ... See full document
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Polyomavirus Middle T Antigen Induces the Transcription of Osteopontin, a Gene Important for the Migration of Transformed Cells
... Middle T antigen (MT) is the principal oncoprotein of murine ...the polyomavirus enhancer, the same signaling important for viral replication also contributes to virally induced metastatic ... See full document
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The p110α Isoform of Phosphatidylinositol 3-Kinase Is Essential for Polyomavirus Middle T Antigen-Mediated Transformation
... Middle T antigen (MT) of polyomavirus is known to play an important role in virus-mediated cellular transformation. While MT has been extensively examined in spontaneously immortalized rodent ... See full document
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Amino-terminal regions of polyomavirus middle T antigen are required for interactions with protein phosphatase 2A.
... The polyomavirus MT coding region was cloned into Bluescript KS as a XhoI-EcoRI fragment from pMTneoMLV (15, 22) for subsequent ...from polyomavirus DNA con- taining the 3 9 untranslated region and the ... See full document
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Localization of the phosphorylations of polyomavirus large T antigen.
... Hydroxylamine cleavage of large T antigen labeled with [35S]methionine yielded peptides that matched electrophoretically the two phosphorylated fragments.. A third fragment 60K fragment [r] ... See full document
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Serine 257 Phosphorylation Regulates Association of Polyomavirus Middle T Antigen with 14-3-3 Proteins
... Polyomavirus middle T antigen (MT) is phosphorylated on serine residues. Partial proteolytic mapping and Edman degradation identified serine 257 as a major site of phosphorylation. This was ... See full document
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Antibodies against a nonapeptide of polyomavirus middle T antigen: cross-reaction with a cellular protein(s).
... However, unexpected results were obtained when middle T antigen that phosphorylated in in vitro MT kinase reac- and Table 1 establish that the 55K protein immunoprecipitated from wild-ty[r] ... See full document
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Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain.
... mm-diameter plate]) was then added for 2 to 4 h. Cells were washed with ice-cold phosphate-buffered saline (PBS) and lysed in a small volume of radioimmuno- precipitation assay (RIPA) lysis buffer (28) containing ... See full document
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