[PDF] Top 20 Identification of PB2 Mutations Responsible for the Efficient Replication of H5N1 Influenza Viruses in Human Lung Epithelial Cells
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Identification of PB2 Mutations Responsible for the Efficient Replication of H5N1 Influenza Viruses in Human Lung Epithelial Cells
... that PB2-249G, PB2-339M, and PB2-309D support efficient viral growth in A549 ...acid mutations E249G and T339M may be associ- ated with the adaptation of H5N1 virus to ...the ... See full document
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Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells
... in influenza H5N1 virus infected alveolar epithelium We next investigated whether there was polarity in the secretion of cytokine proteins from type I-like alveolar epithelial cells infected ... See full document
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Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human Cells
... of mutations in the PB2 genes on polymerase activity were conducted using minigenome assays that do not yield replication-competent viruses, under biosafety level 2 (BSL2) ...tested ... See full document
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Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses
... seasonal influenza H1N1 virus replicated poorly within AMs and more efficiently in PBDMs ...seasonal influenza H1N1 and H3N2 virus infection in AMs ...of influenza viruses. Although we find ... See full document
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Differential replication of avian influenza H9N2 viruses in human alveolar epithelial A549 cells
... for efficient replication in human ...avian influenza virus sub- types including H4N8, H6N1, and H10N7 is inefficient and this may be due to the inefficient virus replication competence ... See full document
5
Impact of Amino Acid Mutations in PB2, PB1-F2, and NS1 on the Replication and Pathogenicity of Pandemic (H1N1) 2009 Influenza Viruses
... differentiated human tracheobronchial epithelial cells and a swine cell line (9), its growth kinetics in MDCK cells was also comparable to that of wild-type virus; however, different PDZ ... See full document
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Specific Mutations in the PB2 Protein of Influenza A Virus Compensate for the Lack of Efficient Interferon Antagonism of the NS1 Protein of Bat Influenza A-Like Viruses
... ) cells and ...A-like viruses is likely responsible for their ...in cells and mice, consistent with an impaired ability of the NS1 from bat influenza A-like viruses to block the ... See full document
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Highly Pathogenic Avian Influenza H5N1 Viruses Elicit an Attenuated Type I Interferon Response in Polarized Human Bronchial Epithelial Cells
... of influenza virus replication in humans, the aim of this study was to estab- lish a human respiratory epithelial cell model to better under- stand the virulence of avian H5N1 ... See full document
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Lysosome associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells
... for influenza virus replication by using genome-wide RNA interference screenings in con- junction with other integrative genomics strategies ...by influenza viruses and highlighted potential ... See full document
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Oct4+ Stem/Progenitor Swine Lung Epithelial Cells Are Targets for Influenza Virus Replication
... of lung function and the loss of capacity for lung repair after influenza virus infection are not well ...several human autopsy studies from previous influenza pandemics, including the ... See full document
7
Human Pulmonary Microvascular Endothelial Cells Support Productive Replication of Highly Pathogenic Avian Influenza Viruses: Possible Involvement in the Pathogenesis of Human H5N1 Virus Infection
... unlike human bronchial epithelial cells, which are permissive to productive replication of both avian and human influenza viruses and express avian-like ␣-2,3-linked and ... See full document
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Bat lung epithelial cells show greater host species-specific innate resistance than MDCK cells to human and avian influenza viruses
... with influenza A virus. Inhibition of NF-κB signalling in murine and human respiratory epithelial cells has been shown to reduce both virus replication and production of pro- ... See full document
11
Bat lung epithelial cells show greater host species specific innate resistance than MDCK cells to human and avian influenza viruses
... with influenza A virus. Inhibition of NF-κB signalling in murine and human respiratory epithelial cells has been shown to reduce both virus replication and production of pro- ... See full document
10
Molecular Determinants of Adaptation of Highly Pathogenic Avian Influenza H7N7 Viruses to Efficient Replication in the Human Host
... avian influenza viruses from aquatic birds to other species (28, ...from replication in the original host toward replication in ...These replication-enhancing mutations ... See full document
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NP, PB1, and PB2 Viral Genes Contribute to Altered Replication of H5N1 Avian Influenza Viruses in Chickens
... increased replication of AIVs in ...reassortant viruses are not necessarily ...the replication and pathogenesis of AIVs in chick- ...reassortant viruses and may be contributing factors in the ... See full document
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Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
... Conclusion H5N1 subtype influenza A viruses associated with human disease are more potent than human H1N1 virus at induc- ing proinflammatory cytokines and chemokines, includ- ing ... See full document
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PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host
... IMPORTANCE Influenza A/H5N1 viruses are avian pathogens that have pandemic potential, since they are spread over large parts of Asia, Af- rica, and Europe and are occasionally transmitted to ...these ... See full document
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Mutations to PB2 and NP Proteins of an Avian Influenza Virus Combine To Confer Efficient Growth in Primary Human Respiratory Cells
... how influenza A viruses adapt to new host species, the picture remains ...of influenza viruses cir- culating in wild birds and domestic animals, as well as full-genome sequencing of isolates ... See full document
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Effect of human activated NRAS on replication of delNS1 H5N1 influenza virus in MDCK cells
... MDCK cells. The delNS1 H5N1 influenza virus with deletion of NS1 eIF4GI binding domain was weak multiplication in MDCK ...the replication of delNS1 virus and expression of IFN-beta and IRF-3 ... See full document
5
Differential Susceptibilities of Human Lung Primary Cells to H1N1 Influenza Viruses
... to influenza. In fact, influenza virus infections with inbred mouse strains have demonstrated the importance of genetic fac- tors to variation of susceptibility to influenza (39, ...avian ... See full document
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