[PDF] Top 20 Identification of the DNA Sequence Interacting with Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1
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Identification of the DNA Sequence Interacting with Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1
... Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, a recently discovered human DNA tumor virus, is strongly associated with the development of Kaposi’s sar- ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 Targets MDM2 To Deregulate the p53 Tumor Suppressor Pathway
... by interacting with MDM2 while leaving the E3 ligase activity of MDM2 toward p53 ...closely associated with vIRF4-MDM2 interaction, given that the MDM2 noninterac- tive vIRF4 (1-605) mutant lost this ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene
... undergoing DNA synthesis during S ...KSHV viral-DNA synthe- sis and cellular-DNA synthesis simultaneously, we performed small-molecule DNA fluorescence in situ hybridization ... See full document
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Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma Associated Herpesvirus Induced Lymphangiogenesis
... hypersprouting formation in LECs, we performed mass spectrometry analysis to identify vIRF3-associated proteins using tetracycline-inducible V5-tagged vIRF3-expressing cell lines. TRExBCBL-1 V5/vIRF3 cells ... See full document
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Cooperation between Viral Interferon Regulatory Factor 4 and RTA To Activate a Subset of Kaposi's Sarcoma-Associated Herpesvirus Lytic Promoters
... Activation of the K10/vIRF4 promoter by RTA has not been reported. To address this, we generated a luciferase reporter con- struct using a 0.9-kbp fragment taken immediately upstream of the K10/vIRF4 initiator codon ... See full document
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Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-Associated Herpesvirus Interacts with a Cell Death Regulator, GRIM19, and Inhibits Interferon/Retinoic Acid-Induced Cell Death
... Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV8), is a recently discovered human DNA tumor virus that plays a critical role in the de- ... See full document
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Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer
... aposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), is a DNA tumor virus of the gammaherpesvirus subfamily that has been associated with all ... See full document
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Functional Analysis of Human Herpesvirus 8-Encoded Viral Interferon Regulatory Factor 1 and Its Association with Cellular Interferon Regulatory Factors and p300
... Human herpesvirus 8/Kaposi sarcoma-associated virus (HHV-8/KSHV) contains, in addition to genes required for viral replication, a unique set of nonstructural genes which may be part of ... See full document
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Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication
... of sequence conservation with the ␣ 1 helix sequence of MHV-68 M11 ...or viral binding partners through its ␣1 helix pep- tide, and this interaction might be essential for the tight ... See full document
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Identification, expression, and immunogenicity of Kaposi's sarcoma-associated herpesvirus-encoded small viral capsid antigen.
... nucleotide sequence of the insert in each plasmid was determined from both ends; homologs were sought in the ...and herpesvirus saimiri (HVS) ORF65 (1, ...(8). DNA sequences of this 716-bp ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4/K10) Is a Novel Interaction Partner of CSL/CBF1, the Major Downstream Effector of Notch Signaling
... For the yeast two-hybrid approach, a series of deletion con- structs of vIRF4 encompassing N-terminal, C-terminal, and internal vIRF4 fragments was generated. These vIRF4 frag- ments were coexpressed in the yeast strain ... See full document
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ORF45 of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Phosphorylation of Interferon Regulatory Factor 7 by IKKε and TBK1 as an Alternative Substrate
... (aa 1 to 115), GST-ORF45 (aa 116 to 237), GST-ORF45 (aa 238 to 332), and GST-ORF45 (aa 333 to 407), as well as GST-IRF7 (aa 452 to 503) and control GST-S6 and GST proteins were purified from Escherichia coli and ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Targets Expression of Cellular IRF4 and the Myc Gene To Facilitate Lytic Replication
... smFISH. Single-molecule fluorescence in situ hybridization (smFISH) experiments were performed according to the protocol of Raj et al. (28). TRExBCBL-1 pcDNA and TRExBCBL-1 vIRF4/Au cells were treated with ... See full document
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Cloning and Functional Analysis of Kaposi’s Sarcoma-Associated Herpesvirus DNA Polymerase and Its Processivity Factor
... extended DNA products (.7,000 nucleotides in the in vitro DNA synthesis assay), whereas without PF-8, Pol-8 can incorporate only several nu- ...the DNA polymerases of HSV-1 or HHV-6, nor can ... See full document
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Modulation of Human Herpesvirus 8/Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Activator Transactivation by Interferon Regulatory Factor 7
... Plasmids. Expression plasmids pcDNA-ORF50, which encodes the full-length HHV-8 RTA, and pCMV-Tag50, which encodes a Flag-tagged RTA, were de- scribed previously (45). The p57Pluc1 reporter, containing the 453-bp HHV-8 ... See full document
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Inhibition of the ATM/p53 Signal Transduction Pathway by Kaposi's Sarcoma-Associated Herpesvirus Interferon Regulatory Factor 1
... significant sequence homology with cellular inter- feron (IFN) regulatory factors (IRFs) and is thus designated viral interferon regulatory protein 1 (vIRF1) (40, ...putative ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus known to establish lifelong latency in the human ...cellular interferon regulatory factors (IRFs), known as ... See full document
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Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-Associated Herpesvirus Binds to p53 and Represses p53-Dependent Transcription and Apoptosis
... fected DNA in each experiment was kept constant by the addition of a blank vector ...of 1, and each luciferase measurement was normalized to the internal control, -galactosidase ...(aa 1 to 42). ... See full document
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Inhibition of Interferon Signaling by the Kaposi's Sarcoma-Associated Herpesvirus Full-Length Viral Interferon Regulatory Factor 2 Protein
... kinase 1 (12, ...that viral threat. The cytoplasmic RNA helicases RIG1 (50) and mda5 (1) are now believed to function in this capacity through the adapter protein IPS-1, at least for RNA ... See full document
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Transcriptional Regulation of the Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor Gene
... transcription factor could be responsible for the transcription induced by treatment with phorbol esters (TPA), the induction of vIRF by TPA treatment in BCBL-1 cells is probably mediated through the ... See full document
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