[PDF] Top 20 Immunogenicity of the outer domain of a HIV 1 clade C gp120
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Immunogenicity of the outer domain of a HIV 1 clade C gp120
... a clade C gp120 backbone with 2 glycosylation site ...the C clade outer domain where it acts as a marker of outer domain ...A C-ter- minal Fc tag ... See full document
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Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04
... The outer domain of the HIV-1 gp120 envelope glycoprotein contains the epitope for broadly neutralizing antibodies directed to the CD4-binding site, many of which are able to neutralize ... See full document
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Characterization of the Outer Domain of the gp120 Glycoprotein from Human Immunodeficiency Virus Type 1
... the gp120 glycoprotein from human immunodeficiency virus type 1 (HIV-1) is comprised of three major structural domains: the outer domain, the inner domain, and the ... See full document
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Immunogenicity of an Eight Amino Acid Domain Shared by Fas (CD95/Apo-I) and HIV-1 gp120. I. Structural and Antigenic Analysis
... large HIV-1 popula- tion mainly composed of patients with ad- vanced disease and enhanced T-cell apoptosis showed significant levels of anti-VEINCTR–N ...(Fig. 1) for its adjacent peptides on ... See full document
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Antigenicity and Immunogenicity of RV144 Vaccine AIDSVAX Clade E Envelope Immunogen Is Enhanced by a gp120 N-Terminal Deletion
... ⌬11 gp120 induces antibodies blocked by conforma- tional V2 and V1/V2 MAbs in nonhuman ...⌬11 gp120 would be that there would be qualitative dif- ferences in the induced V2 or V1/V2 ...that gp120 ... See full document
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Breadth of Neutralizing Antibodies Elicited by Stable, Homogeneous Clade A and Clade C HIV-1 gp140 Envelope Trimers in Guinea Pigs
... primary HIV-1 isolates for Env stability and identified two viruses, ...(clade C) (32) and 92UG037.8 (clade A) (17), that yielded biochemically homogeneous and stable Env trimers with ... See full document
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Association of mutations in V3/C3 domain with enhanced sensitivity of HIV 1 clade C primary envelopes to autologous broadly neutralizing plasma antibodies
... Fig. 1 a Neutralization of HIV-1 Envs to contemporaneous autologous G37080 BCN ...version. c Alignment of the V3–C4 amino acid sequences of the contemporaneous Envs obtained at the same time ... See full document
8
Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope
... in HIV-1 infection is the HLA class I ...large C-clade-infected African ...that clade-specific differences in HLA associations with disease outcomes may be related to distinct targeting ... See full document
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Immunogenicity of Multiple Gene and Clade Human Immunodeficiency Virus Type 1 DNA Vaccines
... type 1 (HIV-1) gene products from divergent strains is a desirable feature of an AIDS ...multiple HIV-1 genes from different clades for their ability to elicit humoral and cellular ... See full document
9
Rationally Designed Vaccines Targeting the V2 Region of HIV-1 gp120 Induce a Focused, Cross-Clade-Reactive, Biologically Functional Antibody Response
... type 1 (HIV-1) gp120 envelope (Env) correlated with reduced infection rates in studies of HIV, simian-human immunodeficiency virus (SHIV), and simian im- munodeficiency virus ...using ... See full document
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The Highly Conserved Layer-3 Component of the HIV-1 gp120 Inner Domain Is Critical for CD4-Required Conformational Transitions
... monomeric HIV-1 gp120 core in complex with stabilizing ligands such as soluble CD4 (sCD4) and/or anti- bodies (Abs) ...the outer domain of gp120 does not change conformation, ... See full document
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HIV 1 clade C escapes broadly neutralizing autologous antibodies with N332 glycan specificity by distinct mechanisms
... V1 domain between HIV-1 NLR-2007.J48 (S332N) and HIV-1 ...while HIV-1 NLR-2007.J12 expressing V1 region of HIV-1 ...mAbs; HIV-1 NLR-2007.J48 ... See full document
9
Two Highly Variable Vpr84and Vpr85 Residues within the HIV 1 Vpr C Terminal Protein Transduction Domain Control Transductionnal Activity and Define a Clade Specific Polymorphism
... from HIV-1 ...duction domain (PTD). Here we report on a sequence analysis of VPR 77-92 domain using the Los Alamos HIV-1 sequence ...the domain VPR 84 and VPR 85 are ... See full document
8
Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination
... soluble HIV-1 envelope glycoprotein (Env) SOSIP trimers are a design platform for inducing broadly neutralizing antibodies (bNAbs) by vacci- ...and C, delivered simultaneously or sequentially, induce ... See full document
15
The HIV-1 gp120 Major Variable Regions Modulate Cold Inactivation
... shed gp120 by inducing shedding. Cells expressing HIV-1 YU2 Env gps lacking their cytoplasmic tail were used to enhance cell surface ...significant gp120 shedding (11, ...the ... See full document
9
Activities of Transmitted/Founder and Chronic Clade B HIV-1 Vpu and a C-Terminal Polymorphism Specifically Affecting Virion Release
... of HIV-1 infection is marked by a substantial type I interferon response, we hypothesized that T/F Vpu proteins might be optimized for BST2 downmodulation, since they were derived from viruses that ... See full document
17
Characterization and Immunogenicity of a Novel Mosaic M HIV-1 gp140 Trimer
... trimers as protein immunogens has not previously been de- scribed. In this study, we report the production and characterization of a mosaic M (MosM) gp140 trimer. The mosaic M gp140 trimer bound CD4 as well as multiple ... See full document
15
HLA C increases HIV 1 infectivity and is associated with gp120
... of HIV-1 has identified two pol- ymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of ...HLA- C has the potential to ... See full document
15
Immunogenicity of Constrained Monoclonal Antibody A32-Human Immunodeficiency Virus (HIV) Env gp120 Complexes Compared to That of Recombinant HIV Type 1 gp120 Envelope Glycoproteins
... constrained HIV-1 envelope proteins indicates induction of conformational changes in gp120 follow- ing CD4 or MAb A32 binding (1, 13, 23, ... See full document
9
HIV-1 gp120 and Modified Vaccinia Virus Ankara (MVA) gp140 Boost Immunogens Increase Immunogenicity of a DNA/MVA HIV-1 Vaccine
... and 1 ⫻ 10 8 TCID 50 of MVA62B into the upper left limb on weeks 18, 26, and ...received 1 ⫻ 10 8 TCID 50 of MVAgp140, both delivered intramuscularly in 1 ml by needle and syringe to the upper right ... See full document
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