[PDF] Top 20 Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use

... between trials [47 – ...across trials via a random ...similar meta-analysis ...standard meta-analysis statistics directly, and the com- plexity can make interpretation of the results less ... See full document

... chemotherapy, use of erythropoietin stimulating agents, statin use, the biochemical markers (P-selectin, C reactive protein and D-dimer), smoking status, obesity (body mass index), platelet count, leucocyte ... See full document

... study-level meta-analyses and randomised controlled trials (RCTs) cannot thoroughly examine moderators of deterior- ation due to inadequate power (Bower et ...as IPD ... See full document

... small trials showing large adverse effects of vitamin D were to emerge, we do not anticipate that they would greatly alter the results of the one step IPD meta-analy- sis, since any negative signal ... See full document

... and meta-analysis has a number of strengths. First, it used individual patient data (IPD) from the trials rather than summary/group ...data. Analyses based on IPD ... See full document

... the use of a controlled access approach, using a transparent and robust system to review requests and provide secure data access; (ii) seeking consent for sharing IPD from trial participants ... See full document

... requested individual participant data (IPD) from high quality randomized clinical trials of adults with our primary outcomes of interest, pain and functional limitations, and calculated ... See full document

... the individual trial datasets which resulted in the stat- istical models not being adjusted for all relevant con- ...the analyses, we only used data from women allocated to control arms to simplify ... See full document

... an IPD meta-analysis which will include its registration, constituent systematic review to identify all appropriate RCTs on the basis of pre-specified eligibility criteria, the associated data ... See full document

... randomized controlled trials comparing progestogen versus placebo or non- intervention, or comparing different types of progestogen, in asymptomatic women at risk of preterm ...methods, IPD will be ... See full document

... and meta-analysis of randomised controlled trials ...life. IPD were sought from all RCTs identified. Random-effects meta-analyses (two-stage) were used to estimate hazard ... See full document

... ondly, IPD allows for exploration of a differential treat- ment effect in relevant subgroups ...Since IPD meta-analyses include more detailed data on a patient level than aggregated ... See full document

... and meta-analyses of observational studies assessing dietary or supplementary vitamin D intake or ultraviolet B exposure; studies that had vitamin D status as the outcome; studies that investigated the ... See full document

... same participant and can be combined in one model, a 3-level hierarchical model will be used with the appropriate additional random intercept for each par- ... See full document

... and individual dose adjustments are often ...conventional meta-analyses is difficult and many studies report test accuracy of these continuous tests around an artificial cut- off ... See full document

... better use of public funds and may also reduce existing cynicism among some researchers as to the benefit of formulating ...of data sources where pos- sible and favouring distributional data over ... See full document

... This meta-analysis was conducted to examine the efficacy of gabapentin in ...of Controlled Trials (CENTRAL). Randomised controlled trials (RCTs) involving gabapentin and a ... See full document

... estimates controlled for confounding between malaria at enrollment and low birthweight (LBW) by maternal age, gravidity, area of residence, mid-upper arm circumference at enrollment, and HIV ...estimates ... See full document

... for the examined comparisons. This estimate indicates how many SDs the dependent variable (depressive symptoms se- verity or the log odds ratio [OR] of treatment response) changes per SD increase in the predictor ... See full document

... Subgroup analyses in clinical trials should be con- ducted using appropriate statistical tests of interactions, and reporting of subgroup analyses should be complete, with sufficient information to ... See full document