[PDF] Top 20 West Nile Virus-Induced Interferon Production Is Mediated by the Double-Stranded RNA-Dependent Protein Kinase PKR
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West Nile Virus-Induced Interferon Production Is Mediated by the Double-Stranded RNA-Dependent Protein Kinase PKR
... that PKR serves as a potential PRR and other’s results indi- cating that RIG-I serves as a PRR in WNV-infected cells may be explained in part by the experimental methods employed in these ...examining ... See full document
11
The VP35 Protein of Ebola Virus Inhibits the Antiviral Effect Mediated by Double-Stranded RNA-Dependent Protein Kinase PKR
... the interferon-in- duced antiviral response (18). In response to virus infection, PKR forms a homodimer and autophosphorylates on multiple serine, threonine, and tyrosine residues (17, 18, ...convert ... See full document
11
Human Immunodeficiency Virus Type 1 Tat Protein Activates Transcription Factor NF-κB through the Cellular Interferon-Inducible, Double-Stranded RNA-Dependent Protein Kinase, PKR
... transactivator protein of human immunodeficiency virus type 1 (HIV-1) (Tat) is a powerful activator of nuclear factor- B (NF- B), acting through degradation of the inhibitor I B- ␣ ...cellular ... See full document
7
NSs Protein of Rift Valley Fever Virus Induces the Specific Degradation of the Double-Stranded RNA-Dependent Protein Kinase
... fever virus (RVFV) continues to cause large outbreaks of acute febrile and often fatal illness among humans and domesticated animals in Africa, Saudi Arabia, and ...viral protein NSs, which was shown to ... See full document
11
The Murine Double-Stranded RNA-Dependent Protein Kinase PKR Is Required for Resistance to Vesicular Stomatitis Virus
... of PKR in mice has allowed us to determine the contribution of this gene product to IFN-mediated ...that PKR appears to be a critical facet of the innate immune response protecting the host against ... See full document
6
Functional Domains and the Antiviral Effect of the Double-Stranded RNA-Dependent Protein Kinase PKR from Paralichthys olivaceus
... The double-stranded RNA (dsRNA)-dependent protein kinase PKR is thought to mediate a conserved antiviral pathway by inhibiting viral protein synthesis via the ... See full document
13
Cooperative Roles of Fish Protein Kinase Containing Z-DNA Binding Domains and Double-Stranded RNA-Dependent Protein Kinase in Interferon-Mediated Antiviral Response
... fish PKR in the IFN antiviral ...either protein alone, whereas knockdown of both proteins together made fish cells more vulnerable to virus infection than knockdown of either protein alone ... See full document
12
Double-Stranded RNA Binding of Influenza B Virus Nonstructural NS1 Protein Inhibits Protein Kinase R but Is Not Essential To Antagonize Production of Alpha/Beta Interferon
... B virus expresses a structurally related NS1 pro- tein of 281 aa (B/NS1) that has less than 20% sequence identity to the A/NS1 ...the interferon-stimulated gene 15 (ISG15) product and to inhibit its ... See full document
11
The West Nile Virus Capsid Protein Blocks Apoptosis through a Phosphatidylinositol 3-Kinase-Dependent Mechanism
... to virus infection is increased Fas/CD95 expression and/or sensitivity to Fas-mediated apoptosis ...of virus-infected cells and can be triggered by the presence of double-stranded ... See full document
10
Sendai Virus C Protein Plays a Role in Restricting PKR Activation by Limiting the Generation of Intracellular Double-Stranded RNA
... Sendai virus (SeV) C protein is a multifunctional protein that plays important roles in regulating viral genome replication and transcription, antagonizing the host interferon system, ... See full document
9
Blocking Double-Stranded RNA-Activated Protein Kinase PKR by Japanese Encephalitis Virus Nonstructural Protein 2A
... he interferon (IFN)-induced double-stranded RNA (dsRNA)- activated protein kinase (PKR) plays a critical role in host an- tiviral ...defense. PKR is an ... See full document
12
Measles Virus C Protein Impairs Production of Defective Copyback Double-Stranded Viral RNA and Activation of Protein Kinase R
... and protein kinase R (PKR) ...of interferon regulatory factor 3 (IRF3) (20, 21). PKR activation triggers a cellular stress response, which includes eukaryotic translation initiation ... See full document
13
The Cellular TAR RNA Binding Protein, TRBP, Promotes HIV-1 Replication Primarily by Inhibiting the Activation of Double-Stranded RNA-Dependent Kinase PKR
... of PKR is lower in Jurkat cells than in 293T cells, but its expression was induced by interferon treatment ...If PKR is induced by IFN- ␣ but its kinase activity cannot be fully ... See full document
8
The RNA-Binding Protein of a Double-Stranded RNA Virus Acts like a Scaffold Protein
... The double- layered E1-1A particle shares many similarities with the herpesvirus procapsid, partic- ularly with its B capsid (37), a dead-end side particle in which the SP layer remains at the T ⫽ 16 capsid ... See full document
14
In vitro analysis of virus-associated RNA I (VAI RNA): inhibition of the double-stranded RNA-activated protein kinase PKR by VAI RNA mutants correlates with the in vivo phenotype and the structural integrity of the central domain.
... Whether it is a short stem-loop or a large loop in the central domain, our in vitro block assays and the secondary structure analysis suggest that it is this structure that is critical f[r] ... See full document
15
West Nile Virus-Induced Neuroinflammation: Glial Infection and Capsid Protein-Mediated Neurovirulence
... and mediated by the WNV capsid ...velope protein in the ER is the chief trigger for the pathogenic cascade and is one of the features that distinguish particular neurovirulent strains from non-neurovirulent ... See full document
17
Noncytopathic Bovine Viral Diarrhea Virus Inhibits Double-Stranded RNA-Induced Apoptosis and Interferon Synthesis
... nonstructural protein, which is present in ncp BVD V-infected cells in its uncleaved form, NS23, whereas this protein is cleaved into NS2 and NS3 in cells infected with the cp biotype of BVDV (11, ... See full document
7
Double-Stranded RNA-Mediated Interference with Plant Virus Infection
... which double-stranded forms of RNA are involved (5, ...induce virus immunity or gene silencing with almost 100% efficiency when targeted against virus or endogenous genes (35, ...of ... See full document
10
Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities
... HCV RNA replication observed in small numbers of HeLa, 293, or Hepa1-6 cells was determined by adaptations of cellular genes but not by viral evolution ...HCV RNA repli- cation, including the polypyrimidine ... See full document
11
Inhibition of binding to initiation complexes of nascent reovirus mRNA by double-stranded RNA-dependent protein kinase.
... Of necessity, experiments designed to examine whether the binding of nascent reovirus mRNA to initiation complexes was preferentially inhibited in the coupled, cell-free system had to be[r] ... See full document
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