[PDF] Top 20 Influenza A virus M2 ion channel protein: a structure-function analysis.
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Influenza A virus M2 ion channel protein: a structure-function analysis.
... To begin a structure function analysis of the residues in the human influenza virus A/Udorn/72 M, protein TM domain, the pH activation response of the amantadine-resistant mutants V27A, [r] ... See full document
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Influenza Virus M2 Ion Channel Protein Is Necessary for Filamentous Virion Formation
... budding. M2 is expressed at high levels on the surfaces of virus-infected cells (33, ...of M2 protein, suggesting that M2 is actively excluded from the budding virion ...of M2 ... See full document
11
Human Annexin A6 Interacts with Influenza A Virus Protein M2 and Negatively Modulates Infection
... The influenza A virus M2 ion channel protein has the longest cytoplasmic tail (CT) among the three viral envelope proteins and is well conserved between different viral ...of ... See full document
13
Influenza Virus M2 Protein Ion Channel Activity Helps To Maintain Pandemic 2009 H1N1 Virus Hemagglutinin Fusion Competence during Transport to the Cell Surface
... The influenza virus hemagglutinin (HA) envelope protein mediates virus entry by first binding to cell surface receptors and then fusing viral and endosomal membranes during ...the ... See full document
11
Influenza A Virus Can Undergo Multiple Cycles of Replication without M2 Ion Channel Activity
... M2 ion channel activity is believed to function at an early stage in the viral life cycle, between the steps of host cell penetration and uncoating of viral ...M1 protein from viral ... See full document
7
Tyrosines in the Influenza A Virus M2 Protein Cytoplasmic Tail Are Critical for Production of Infectious Virus Particles
... The influenza A virus M2 protein plays a number of key roles in the virus life ...The ion channel activity of the protein is required during virus entry to ... See full document
12
Palmitoylation of the Influenza A Virus M2 Protein Is Not Required for Virus Replication In Vitro but Contributes to Virus Virulence
... HA protein for virus replication in vitro, palmitoylation of the M2 protein appears to be dispensable for replication in a number of different cell types and culture ...and ion ... See full document
7
The Influenza Virus M2 Protein Cytoplasmic Tail Interacts with the M1 Protein and Influences Virus Assembly at the Site of Virus Budding
... of influenza A virus is a complex, multistep process involving the proper organization of viral proteins at the plasma membrane, incorporation of a seg- mented genome, and formation of viral particles by ... See full document
12
Analysis of the Pore Structure of the Influenza A Virus M2 Ion Channel by the Substituted-Cysteine Accessibility Method
... the protein in a twisted conformation that does not conduct ...the protein may return to its native structure, in which case it can conduct at least a small amount of ... See full document
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The Cytoplasmic Tail of the Influenza A Virus M2 Protein Plays a Role in Viral Assembly
... For influenza A viruses, the matrix M1 protein and two membrane integral glycoproteins, hemagglutinin and neuraminidase, function cooperatively in this ...membrane protein, the M2 ... See full document
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Distinct Domains of the Influenza A Virus M2 Protein Cytoplasmic Tail Mediate Binding to the M1 Protein and Facilitate Infectious Virus Production
... of influenza A virus VLPs (20, 31), and our data are consistent with these ...infectious virus titers were reduced drastically in the absence of the M2 cytoplasmic tail, viral protein ... See full document
12
Requirement of Cysteines and Length of the Human Respiratory Syncytial Virus M2-1 Protein for Protein Function and Virus Viability
... carrying M2-1 overlaps with that of M2-2, and the introduction of the premature stop codons in the M2-1 gene of rA2-Tr17 abolished the overlap between the two M2 ...of M2-1 played a ... See full document
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Influenza virus M2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport.
... All the studies reported to date on the effect of amantadine at late times in infection and how it relates to the need to have functional M2 protein ion channel activity to obtain FPV Ro[r] ... See full document
9
The Influenza C Virus CM2 Protein Can Alter Intracellular pH, and Its Transmembrane Domain Can Substitute for That of the Influenza A Virus M2 Protein and Support Infectious Virus Production
... of M2. However, even trace amounts of M2 protein can functionally complement an M2-null influenza A virus (17), so the levels of CM2 expression are ex- pected to be sufficient ... See full document
5
Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7
... better channel-blockage activity than the monomeric amantadine and ...the channel and have no channel inhibition. In contrast, the structure of p7 protein suggests the presence of ... See full document
13
Mutations in the Influenza A Virus M1 Protein Enhance Virus Budding To Complement Lethal Mutations in the M2 Cytoplasmic Tail
... the M2 ORF present in the parental rUd-M2Stop virus in addition to either one or two amino acid mutation(s) in the M1 ORF (Table ...the protein and are present in the N-terminal, middle, and ... See full document
14
A bispecific antibody recognizing influenza A virus M2 protein redirects effector cells to inhibit virus replication in vitro.
... for virus-specific MHC-restricted T cells to inhibit experimental virus ...viral protein ex- pressed on the surface of an infected cell can redirect lysis of the infected cell (5, ...of ... See full document
5
Mutations in the Membrane-Proximal Region of the Influenza A Virus M2 Protein Cytoplasmic Tail Have Modest Effects on Virus Replication
... A virus is a member of the Orthomyxoviridae fam- ily whose genome consists of 8 negative-sense RNA segments which encode 10 or 11 ...membrane protein M2 is encoded by segment 7 via a spliced mRNA, ... See full document
9
Influenza A Virus M2 Ion Channel Activity Is Essential for Efficient Replication in Tissue Culture
... away, N.J.) in DMEM deficient in methionine and cysteine (DMEM met-, cys-) and then lysed and boiled in protein lysis buffer (1% sodium dodecyl sulfate [SDS], 31 mM Tris-HCl [pH 6.8], 2.5% dithiothreitol). To ... See full document
9
Effect of Cytoplasmic Tail Truncations on the Activity of the M2 Ion Channel of Influenza A Virus
... the protein is being expressed. At this pH, the ion channel activity is minimal, and the proton flux across the plasma membrane does not result in oocyte death; however, when bathed in medium of ... See full document
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