[PDF] Top 20 Initial interaction of herpes simplex virus with cells is binding to heparan sulfate.
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Initial interaction of herpes simplex virus with cells is binding to heparan sulfate.
... to determine whether of one DISCUSSION Our results demonstrate that the initial step in infection of HEp-2 cells by HSV-1 and HSV-2 is binding of virions to Downloaded from http://jvi.as[r] ... See full document
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A 3-O-Sulfated Heparan Sulfate Binding Peptide Preferentially Targets Herpes Simplex Virus 2-Infected Cells
... HeLa cells were either untreated or treated with 2 mg/ml G2 peptide for 30 min at ...37°C. Cells were then infected with HSV-2(333) at an MOI of 10 for 4 h at ...h, cells were washed 3 times with 1 ⫻ ... See full document
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Herpes Simplex Virus Glycoprotein B Binds to Cell Surfaces Independently of Heparan Sulfate and Blocks Virus Entry
... the initial binding of gB to HSPG may enhance attachment of gB to a second type of ...This interaction involves the N-terminal subunit of BHV-1 gB, while the entire molecule is required for non-HSPG ... See full document
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Heparan Sulfate Proteoglycan Binding by Herpes Simplex Virus Type 1 Glycoproteins B and C, Which Differ in Their Contributions to Virus Attachment, Penetration, and Cell-to-Cell Spread
... wild-type virus, suggesting that only gB binding to the HS receptor is required for efficient intercellular infection and indicating that the roles of HS binding are different in extra- and ... See full document
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Role for 3-O-Sulfated Heparan Sulfate as the Receptor for Herpes Simplex Virus Type 1 Entry into Primary Human Corneal Fibroblasts
... Herpes simplex virus type 1 (HSV-1) infection of the corneal stroma remains a major cause of ...(3-OS) heparan sulfate (HS)-generating enzyme 3-O sulfotransferase 3 (3-OST-3) but not ... See full document
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A27L Protein Mediates Vaccinia Virus Interaction with Cell Surface Heparan Sulfate
... host cells by ...host cells by binding to cell surface proteins, which may vary among tissue ...the virus. Receptor-mediated viral binding is shared by many vi- ruses; however, the ... See full document
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Herpes Simplex Virus Types 1 and 2 Differ in Their Interaction with Heparan Sulfate
... reduced binding of HS by HSV-2 virions compared to HSV-1 particles, we focused on the structural differences between gC-1 and ...the virus binding to cells (49; Mårdberg et ...the ... See full document
9
Viral and Cellular Determinants of the Hepatitis C Virus Envelope-Heparan Sulfate Interaction
... with cells incubated with envelope proteins at the concentration indicated on the x ...E1 binding are indicated by asterisks ( ⴱ , P ⬍ ...(B) Binding of E1 and E2 to human hepatoma (Huh-7 and HepG2), ... See full document
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Mediation of human immunodeficiency virus type 1 binding by interaction of cell surface heparan sulfate proteoglycans with the V3 region of envelope gp120-gp41.
... the binding to infected H9 cells was most sensitive to soluble HS showed the highest degree of overlap with heparitinase in blocking the binding of soluble envelope to the surface of H9h ...b ... See full document
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Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells
... the initial virus attachment to the cell surface ...papillomavirus, herpes simplex virus, and influ- enza A virus, and a similar strategy can be explored for EBOV [33 – ... See full document
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Adaptation of Sindbis Virus to BHK Cells Selects for Use of Heparan Sulfate as an Attachment Receptor
... HS-independent interaction of TR339 with cells is not saturable and is barely measurable in a variety of cell binding ...when binding assays are done with cell suspensions or monolayers, and ... See full document
10
Interaction Domains of the UL16 and UL21 Tegument Proteins of Herpes Simplex Virus
... the interaction network in which the conserved UL16 tegument protein ...infected cells, as determined by coimmunoprecipitation assays ...the interaction; indeed, UL16 and UL21 were found to directly ... See full document
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Inhibition of Human Metapneumovirus Binding to Heparan Sulfate Blocks Infection in Human Lung Cells and Airway Tissues
... the cells and tissues with SB105-A10, which specifi- cally occludes any ligand binding to HSPGs, resulted in a signifi- cant inhibition of HMPV binding and ...direct binding interaction ... See full document
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Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate.
... disease virus (FMDV) enters cells by attaching to cellular receptor molecules of the integrin family, one of which has been identified as the RGD-binding integrin a v b ...integrin binding ... See full document
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Interaction of Classical Swine Fever Virus with Membrane-Associated Heparan Sulfate: Role for Virus Replication In Vivo and Virulence
... ConA binding to CSFV variants indicated that N-linked gly- cans with terminal mannose residues are present on the sur- face of ...(e.g., sulfate and phosphate groups [23, 29]) is dependent on the routing of ... See full document
11
Human Herpesvirus 8 Envelope Glycoprotein K8.1A Interaction with the Target Cells Involves Heparan Sulfate
... single virus is not unexpected, since all well-studied human alpha- and beta- herpesviruses contain at least two HS binding glycoproteins, ...two-HS binding proteins within the same virus ... See full document
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Hepatitis C Virus Attachment Mediated by Apolipoprotein E Binding to Cell Surface Heparan Sulfate
... for interaction with NS5A, and the apoE-NS5A interaction is critical to HCV assembly and production (12, ...of heparan sulfate from cell surface by heparinase treatment reduced the ... See full document
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Heparan Sulfate Glycosaminoglycans Are Receptors Sufficient To Mediate the Initial Binding of Adenovirus Types 2 and 5
... nodeficiency virus type 1 Tat protein binds to HS chains only above a minimal critical size, the binding affinity being also modulated by length variations ...interestingly, interaction of HS GAGs ... See full document
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Characterization of Hepatitis C Virus Interaction with Heparan Sulfate Proteoglycans
... the binding of HCV virions to ...this initial step of the HCV life ...this interaction (24, 26, ...coprotein interaction with ...HVR1 binding to heparin-coated beads, suggesting that in ... See full document
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Herpes Simplex Virus 1 Interaction with Myeloid Cells In Vivo
... myeloid cells but not through SSMs. As vesicular stomatitis virus (VSV) can replicate in SSMs (51), it is unclear why herpesviruses have not evolved to do ...greater initial HSV-1 delivery to neurons ... See full document
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