[PDF] Top 20 An Integrated In-Silico Approach to Develop Epitope-Based Peptide Vaccine against SARS-CoV-2
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An Integrated In-Silico Approach to Develop Epitope-Based Peptide Vaccine against SARS-CoV-2
... B-cell epitope was Bepipred linear epitope prediction tool ...is based on Hidden Markov Model and is one of the best methods for prediction of linear B-cell ...linear epitope prediction tool ... See full document
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A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS‐COV‐2 by Comprehensive Immunoinformatic and Molecular Modelling Approach
... design peptide vaccines to counter SARS-CoV-2 S protein, Mpro, Nsp 12 RNA polymerase (RdRp) and Nsp13 ...(multiepitope vaccine) complexes and analysis was done as these are proved ... See full document
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In Silico Epitope-Based Peptide Vaccine Design against Invasive Non Typhoidal Salmonella (iNTS) Through Immunoinformatic Approaches
... online based molecular docking platform worked on shape complementarity of soft molecular ...desired epitope as ligand in a blind manner means the epitope will bind to the best conceivable place not ... See full document
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COVID-19 Vaccine Candidates by Identification of B and T Cell Multi-Epitopes Against SARS-COV-2
... Coronavirus 2 or ...of SARS-COV-2 proteome as a vaccine candidate by analysing through B-cell and T-cell antigenicity by using a immunoinformatics approach as a vaccine ... See full document
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Structural basis of development of multi-epitope vaccine against Middle East respiratory syndrome using in silico approach
... MEVs against MERS-CoV that consisted of CTL and HTL ...in silico methods for their molecular interaction with HLA alleles and TAP (for CTL ...in silico validation of both the CTL and HTL MEVs, ... See full document
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In silico-based vaccine design against Ebola virus glycoprotein
... definite vaccine or other remedial agents have been developed yet for the management and avoidance of EBOV infections in ...an epitope-based peptide vaccine against EBOV, using a ... See full document
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A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS‐COV‐2 by Comprehensive Immunoinformatic and Molecular Modelling Approach
... First 11 yellow peptides belong to SARS-CoV-2 spike protein till ECSNLLLQY, next 4 peptide belong to Mpro till TANPKTPKY, next 19 peptides from RdRp till CCSLSHRFY followe[r] ... See full document
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Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach
... an epitope-based vaccine designed for ...computational approach was adopted to identify a multiepitope vaccine candidate against this virus that could be suitable to trigger a ... See full document
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Epitope Based Vaccine Strategy against Sea Anemone Toxins through in Silico Route
... therefore vaccine therapy becomes ...predict epitope from antigenic proteins in a specific way resulting in specific, secured and optimized peptide-based vaccine design ...the ... See full document
9
While We Wait for a Vaccine Against SARS-CoV-2, Why Not Think About Available Drugs?
... to SARS to SARS-CoV-2 (Rockx et ...viriomics approach, the receptor binding domain of lineage B (beta)-CoVs can be divided into functionally distinct ... See full document
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Promising Multiple-Epitope Recombinant Vaccine against Foot-and-Mouth Disease Virus Type O in Swine
... of 2⫻ staining reagent was added to a 96-well micro- plate, and a series of different volumes (0, 1, 2, 4, 6, 8, and 10 l) of standard bovine serum albumin (BSA, 1 mg/ml; Sigma) were added in duplicate to ... See full document
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In silico study of SARS-CoV-2 Nucleocapsid Protein-Protein Interactions and Potential Candidates for their Stabilization
... showed that several compounds effectively sta- bilize one or more of the studied interfaces. At first, it was thought that the lack of experi- mental data made it almost impossible to es- tablish a cutline and select the ... See full document
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Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs
... newest SARS-CoV-2 (the causative agent of COVID-19) lead to severe and deadly diseases with mortality rates ranging between ~1 to 35% depending on factors such as age and pre-existing ...anti- ... See full document
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An in silico analysis of drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection
... COVID-19 based on interactome analyses also identified several compounds that we identify here including verapamil or inhibitors of Bromodomains and RAF kinases ... See full document
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SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional Convergence
... including SARS-CoV [44], and in HIV has been an immense source of polymorphisms and evolution ...in SARS-CoV-2 genomes, clonal nature of mutations in different geographical regions was ... See full document
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CRISPR-Based Assays for Rapid Detection of SARS-CoV-2
... strip based detection: Cleaved FITC bearing part of reporter probe present only in positive samples get accumulated at test band and further get visible due to gold nanoparticle conjugated anti-FITC antibody ... See full document
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Structural Similarity Analysis of Spike Proteins of SARS-CoV-2 and Other SARS-related Coronaviruses
... with SARS- CoV-2, with 96% identity at the whole-genome level ...between SARS-CoV-2 and other SARS-related other ...of SARS-CoV-2 was found to be very ... See full document
19
Current scenario of vaccine development against a neglected disease: visceral leishmaniasis
... a vaccine against VL is imperative and knowing the fact that recovered individuals developed lifelong immunity against re-infection, it is ...feasible. Vaccine development program, though time ... See full document
5
Mycophenolate Mofetil Is Active Against SARS-CoV-2 in Vero E6 Cells
... Mycophenolic acid, its salt mycophenolate sodium and its prodrug mycophenolate mofetil (Fig.2) are selective, non-competitive, and reversible inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors which were ... See full document
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Potential for Developing a SARS-CoV Receptor Binding Domain (RBD) Recombinant Protein as a Heterologous Human Vaccine against Coronavirus Infectious Disease (COVID)-19
... mAbs to evaluate their cross-reactivity to SARS-CoV-2 RBD (Table 2). Among these 5 neutralizing mAbs, the four mAbs that bound the epitopes in or close to RBM expectedly only had weak or no ... See full document
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