[PDF] Top 20 Interaction and Interdependent Packaging of Tegument Protein UL11 and Glycoprotein E of Herpes Simplex Virus
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Interaction and Interdependent Packaging of Tegument Protein UL11 and Glycoprotein E of Herpes Simplex Virus
... mutant UL11(CCC-) also packaged normal amounts of gE ...its UL11 derivative could not be detected in cell lysates or virions ...of UL11 is needed for helping gE to get packaged, and entry into lipid ... See full document
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A Network of Protein Interactions around the Herpes Simplex Virus Tegument Protein VP22
... The glycoprotein-binding domain of VP22 is conserved among all VP22 homologues (41), suggesting that the gE-VP22-gM complex may be important for alphaherpesvirus ...that UL11, UL16, and UL13 all bind to gE, ... See full document
12
Direct and Specific Binding of the UL16 Tegument Protein of Herpes Simplex Virus to the Cytoplasmic Tail of Glycoprotein E
... with UL11, UL21, and the capsid. Thus far, it is clear that the interaction with UL21 is not sensitive to NEM (28), as is the case for the gE interaction (shown here), but these limited observations ... See full document
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Cytoplasmic Residues of Herpes Simplex Virus Glycoprotein gE Required for Secondary Envelopment and Binding of Tegument Proteins VP22 and UL11 to gE and gD
... and UL11 were solubilized under these extraction conditions by using Western blot analyses to probe pelleted material ver- sus protein in supernatants after centrifugation at 60,000 ⫻ ...of UL11 and ... See full document
13
Domain Interaction Studies of Herpes Simplex Virus 1 Tegument Protein UL16 Reveal Its Interaction with Mitochondria
... Activating mutations enable full-length UL16 to localize to mitochondria. Further evidence that UL16 contains intrinsic mitochondrial targeting information was found in studies performed in the absence of the Src ... See full document
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Interaction Domains of the UL16 and UL21 Tegument Proteins of Herpes Simplex Virus
... UL16 protein of herpes simplex virus is capsid associated and was previously identified as a binding partner of the membrane-associated UL11 tegument protein ...a ... See full document
9
Elucidation of the Block to Herpes Simplex Virus Egress in the Absence of Tegument Protein UL16 Reveals a Novel Interaction with VP22
... membrane protein UL11, which suggested a “bridging” function during cytoplasmic envelopment, but this conjecture has not been ...the packaging of glycoprotein E (gE) was observed, which ... See full document
10
Dynamic Interactions of the UL16 Tegument Protein with the Capsid of Herpes Simplex Virus
... UL16 tegument protein of herpes simplex virus is conserved throughout the herpesvirus ...an interaction with the membrane-bound UL11 ...the interaction is transient ... See full document
9
Virion Incorporation of the Herpes Simplex Virus Type 1 Tegument Protein VP22 Occurs via Glycoprotein E-Specific Recruitment to the Late Secretory Pathway
... VP22-gE interaction occurs before the majority of capsids have entered the maturation ...inner tegument protein UL37 localizes to the Golgi region of the cell in the absence of capsid structures but ... See full document
15
The Unusual Fold of Herpes Simplex Virus 1 UL21, a Multifunctional Tegument Protein
... Herpes simplex virus 1 (HSV-1) UL21 is a 535-amino-acid tegument protein that is conserved within the Alphaherpesvirus subfamily (8) and may have analogs among other ...pseudorabies ... See full document
6
Herpes Simplex Virus Type 1 Glycoprotein K and the UL20 Protein Are Interdependent for Intracellular Trafficking and trans-Golgi Network Localization
... heterodimeric protein complexes involve direct interac- tions between the partner ...this interaction is necessary for their intracellular transport, localization, and ... See full document
16
Packaging Determinants in the UL11 Tegument Protein of Herpes Simplex Virus Type 1
... of UL11 species inherent in the assay raises at least three unanswered ...wild-type UL11 assist in the packaging of any of the trans-expressed mutants or is it truly just a competitor? So far, no ... See full document
8
Analysis of the Interaction between the UL11 and UL16 Tegument Proteins of Herpes Simplex Virus
... the protein that is highly conserved ...tact UL11, there are several other (perhaps more likely) pos- sibilities for what they ...the protein, much like any other amino acid in ...example, ... See full document
8
Intracellular Trafficking of the UL11 Tegument Protein of Herpes Simplex Virus Type 1
... During herpes simplex virus type 1 (HSV-1) assembly, over 30 different proteins come together to form three major struc- tures: the nucleocapsid, the glycoprotein-containing envelope, and the ... See full document
11
Regulated Interaction of Tegument Proteins UL16 and UL11 from Herpes Simplex Virus
... the protein does not have obvious nu- clear import and export ...with UL11 were strikingly absent from the nuclei of some of the cotransfected cells ...brane-bound UL11 may simply prevent UL16 from ... See full document
13
Herpes Simplex Virus Tegument Protein US11 Interacts with Conventional Kinesin Heavy Chain
... capsid protein VP5 and the stalk of human uKHC, ...Extracellullar virus labeled only with ...extracellular virus, with only sparse background label outside the ... See full document
10
Herpes Simplex Virus Capsid-Organelle Association in the Absence of the Large Tegument Protein UL36p
... fluorescent protein (GFP) to the small capsid sub- unit VP26, similar to that originally described by the Desai labo- ratory (58; Gregory ...this virus, we tested its replication in Vero cells and in the ... See full document
11
The UL21 Tegument Protein of Herpes Simplex Virus 1 Is Differentially Required for the Syncytial Phenotype
... FIG 3 Morphology of capsids produced by the UL21 deletion virus. (A to F) Vero or G5 cells were infected at an MOI of 10 with either wild-type or ΔUL21 virus. The samples were fixed and processed for ... See full document
18
Herpes Simplex Virus Type 1 Glycoprotein E Domains Involved in Virus Spread and Disease
... of virus travel within epidermal or neuronal cells, that gE is involved in release of virus into synaptic spaces, and that gE is required for efficient transport of virus from one cell to another ... See full document
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Phosphorylation of the Herpes Simplex Virus Tegument Protein VP22 Has No Effect on Incorporation of VP22 into the Virus but Is Involved in Optimal Expression and Virion Packaging of ICP0
... VP22-MT interaction may be dominant over the VP22-VP16 interaction in infected ...that virus grown in the absence of VP22 displays a delay in the initiation of viral protein synthesis, ... See full document
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