[PDF] Top 20 Interleukin-15 Increases Effector Memory CD8+ T Cells and NK Cells in Simian Immunodeficiency Virus-Infected Macaques
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Interleukin-15 Increases Effector Memory CD8+ T Cells and NK Cells in Simian Immunodeficiency Virus-Infected Macaques
... in effector memory CD8 ⫹ T-cell numbers during the IL-15 administration phase, we did not find an increase in virus-specific CD8 ⫹ T cells as detected by ... See full document
9
Simian Immunodeficiency Virus (SIV) Infection Influences the Level and Function of Regulatory T Cells in SIV-Infected Rhesus Macaques but Not SIV-Infected Sooty Mangabeys
... in memory CD4 T cells within the first 3 weeks resulted in a larger Treg:CD4 ...of memory CD4 T ...of effector T-cell responses at a time when immune control and viral ... See full document
12
Loss of Naïve Cells Accompanies Memory CD4+ T-Cell Depletion during Long-Term Progression to AIDS in Simian Immunodeficiency Virus-Infected Macaques
... ⫹ T lym- phocytes was a prominent feature observed during all long- term SIV infections in IP and CP animals ...CP macaques sustained a much greater loss of circulating naı¨ve CD4 ⫹ T cells ... See full document
10
Extralymphoid CD8+ T Cells Resident in Tissue from Simian Immunodeficiency Virus SIVmac239Δnef-Vaccinated Macaques Suppress SIVmac239 Replication Ex Vivo
... ⴙ T-cell viral suppression assay (VSA). Infected targets were plated in 96-well plates at 25,000 ...priate effector/target (E/T) ratio. After 4 days in culture, cells were initially ... See full document
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Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation
... Target cells were generated from freshly isolated peripheral blood mononuclear cells (PBMC) obtained from SIV-naive Indian rhesus macaques using Ficoll-Paque PLUS (Amersham Biosciences, Uppsala, ... See full document
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Simian Immunodeficiency Virus (SIV) Infection of a Rhesus Macaque Induces SIV-Specific CD8+ T Cells with a Defect in Effector Function That Is Reversible on Extended Interleukin-2 Incubation
... two infected Mamu-A*01-positive macaques (Mamu-A*01 typed by PCR with sequence-specific primers by the method of Knapp et ...acutely infected with an intravenous challenge of highly pathogenic ... See full document
6
Dynamics of T-Cell Responses and Memory T Cells during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques
... of memory CD8 ⴙ T cells in the pe- ripheral lymphoid tissues of SIV-infected ...central memory, and effector memory cells in CD4 ⫹ and CD8 ⫹ ... See full document
13
Activated Memory CD4+ T Helper Cells Repopulate the Intestine Early following Antiretroviral Therapy of Simian Immunodeficiency Virus-Infected Rhesus Macaques but Exhibit a Decreased Potential To Produce Interleukin-2
... IL-2, cells were subjected to two-color flow cytometric analysis by methods previously described (11, 29, ...Briefly, cells were labeled with anti-CD4 conjugated to PE and incubated for 30 min at ...PBS, ... See full document
9
Virus Inhibition Activity of Effector Memory CD8+ T Cells Determines Simian Immunodeficiency Virus Load in Vaccinated Monkeys after Vaccine Breakthrough Infection
... human immunodeficiency virus 1 (HIV-1) acqui- ...with simian immunodeficiency virus strain mac239 (SIVmac239) Gag-Pol and Env provided protection against pathogenic SIVsmE660 ... See full document
8
Bone Marrow-Derived CD4+ T Cells Are Depleted in Simian Immunodeficiency Virus-Infected Macaques and Contribute to the Size of the Replication-Competent Reservoir
... administration, memory CD4 ⫹ T cells were reconstituted in both BM and PB ...BM memory CD8 ⫹ T cells were increased in frequency during early chronic infection, comparable ... See full document
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Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques
... which CD8 ⫹ T lymphocytes exert an an- tiviral effect in vivo still are incompletely ...(i) CD8 ⫹ T lymphocytes may reduce production of virions on a per-cell basis either by direct killing of ... See full document
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Initiation of Antiretroviral Therapy Restores CD4+ T Memory Stem Cell Homeostasis in Simian Immunodeficiency Virus-Infected Macaques
... isolation, cells were resuspended in 30 to 50 ml phosphate-buffered saline (PBS) containing 2 mM EDTA and spun at 200 ⫻ g for 15 to 20 min (depending on cell volume) to remove contam- inating ...⫹ T ... See full document
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Simian Immunodeficiency Virus-Producing Cells in Follicles Are Partially Suppressed by CD8+ Cells In Vivo
... follicular CD8 ⫹ T cells in controlling viral ...and infected cells from B cell ...follicular virus-specific CD8 ⫹ T cells to enhance viral ...⫹ ... See full document
13
Detection of simian immunodeficiency virus (SIV)-specific CD8+ T cells in macaques protected from SIV challenge by prior SIV subunit vaccination.
... protected macaques were evaluated between 10 and 80 weeks postchal- lenge (Table ...by cells infected with the virus but not by the ...to virus challenge and stimulated with autologous ... See full document
7
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
... applications, T cells of a desired antigen specificity are isolated or engineered to express receptors that target infected or transformed cells and are then expanded in culture ...cloned ... See full document
13
Increased Loss of CCR5+ CD45RA− CD4+ T Cells in CD8+ Lymphocyte-Depleted Simian Immunodeficiency Virus-Infected Rhesus Monkeys
... Confocal microscopy. Tissue sections were stained for viral SIV RNA as outlined above with the following modifications. All samples were treated with a methonolic-hydrogen peroxide solution to quench endogenous ... See full document
13
Acute and Chronic T Cell Dynamics in the Livers of Simian Immunodeficiency Virus-Infected Macaques
... of CD8 ⫹ T lympho- cytes that accumulate in the liver in the setting of various systemic viral infections are trapped, “end-stage” cells that will eventually be eliminated by apoptosis (2, ...of ... See full document
9
Protracted Course of Lymphocytic Choriomeningitis Virus WE Infection in Early Life: Induction but Limited Expansion of CD8+ Effector T Cells and Absence of Memory CD8+ T Cells
... mice infected at 2 weeks of age ...of CD8 ⫹ T effector T cells and the lack of induction of memory CD8 ⫹ T cells, suggesting that other ... See full document
13
Control of Simian Immunodeficiency Virus Replication by Vaccine-Induced Gag- and Vif-Specific CD8+ T Cells
... escape-variant immunodeficiency viruses in ...Allen T, Prado JG, Altfeld M, Brander C, Dixon C, Ramduth D, Jeena P, Thomas SA, St John A, Roach TA, Kupfer B, Luzzi G, Edwards A, Taylor G, Lyall H, ... See full document
9
Enteric Ganglionitis in Rhesus Macaques Infected with Simian Immunodeficiency Virus
... and simian immunodeficiency virus (HIV and SIV) infections (3, 17, 18, 22, 29, 30, 33, 39, 43, 56, 60, ...HIV- infected patients with GI disease and likely contribute to the development of ... See full document
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