[PDF] Top 20 Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression
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Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression
... HIV-1 Tat protein as a substrate for ...arginine methylation but also the first time that Tat was identified as the first functional substrate for ...Arginine methylation often takes ... See full document
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Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region
... of Tat, we asked whether methylation might affect its association with cellular factors, such as P-TEFb (cyclin T1 and ...of Tat-TAR-cyclin T1 complexes was severely impaired when using methylated ... See full document
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Arginine Methylation Increases the Stability of Human Immunodeficiency Virus Type 1 Tat
... of Tat in the ...if PRMT6 altered the steady-state level of Tat, we cotransfected HeLa cells to over- express PRMT6 with either wild-type Tat or a mutant of Tat in which ... See full document
10
Mutations in the tat Gene Are Responsible for Human Immunodeficiency Virus Type 1 Postintegration Latency in the U1 Cell Line
... defective virus genomes raises the question of whether replication-competent HIV can establish a true state of latent ...infectious virus and a host cell that is capable of being reversed to allow ... See full document
5
Potent Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Gene Expression and Virus Production by an HIV-2 Tat Activation-Response RNA Decoy
... decrease Tat activity have all focused on TAR-1, which is structurally diver- gent from the TAR region of HIV-2 (TAR-2) ...HIV-2 Tat transactivating proteins (Tat-1 and Tat-2, ... See full document
5
Novel Tat-Encoding Bicistronic Human Immunodeficiency Virus Type 1-Based Gene Transfer Vectors for High-Level Transgene Expression
... FIG. 1. Schematic representation of HIV-1 packaging constructs (A), provirus (B), and gene transfer vectors ...and gene transfer vectors were derivatives of the molecular clone pNL4-3 (GenBank ... See full document
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Acetylated Tat Regulates Human Immunodeficiency Virus Type 1 Splicing through Its Interaction with the Splicing Regulator p32
... acetylated Tat, we used a proteomic approach to identify cellular factors that differentially interacted with unmodified or acetylated ...chose Tat peptides (aa 36 to 53) containing the core region as well ... See full document
16
Cytokine regulation of human immunodeficiency virus type 1 gene expression in cells of neural origin
... The detection of mRNA transcripts from the HIV-1 LTR was possible only using large amounts (100/4g) of cytoplasmic RNA isolated from a clone of G26-24 oligodendroglioma cells which expressed CAT under the control ... See full document
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Transient Induction of Cyclin T1 during Human Macrophage Differentiation Regulates Human Immunodeficiency Virus Type 1 Tat Transactivation Function
... CycT1 expression at late time points in ...protein expression late in MDM differentia- tion could be reversed by macrophage ...CycT1 expression was detected at day 13 in donor 27 and at day 14 in ... See full document
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Transcriptional Restriction of Human Immunodeficiency Virus Type 1 Gene Expression in Undifferentiated Primary Monocytes
... HIV-1 gene expression was im- paired in infected primary monocytes, in addition to previously identified restrictions in the early viral life ...of Tat transactivation of the LTR promoter ... See full document
10
The human immunodeficiency virus type 1 Tat protein transactivates tumor necrosis factor beta gene expression through a TAR-like structure.
... To determine the role played by the upstream regulatory regions of the TNF,B promoter in Tat-mediated transactivation, 5' deletion mutants of the TNF3 promoter region relative to the tra[r] ... See full document
6
The full-length Tat protein is required for TAR-independent, posttranscriptional trans activation of human immunodeficiency virus type 1 env gene expression.
... 7 0022-538X/93/073739-09$02.00/0 Copyright © 1993, American Society for Microbiology The Full-Length Tat Protein Is Required for TAR-Independent, Posttranscriptional trans Activation of [r] ... See full document
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Evidence for Gene Expression by Unintegrated Human Immunodeficiency Virus Type 1 DNA Species
... of tat, rev, and nef mRNA were used to quantify multiply spliced viral transcripts ...Table 1. RT-PCR experiments were performed on 1/50 of total cell RNA in a 20-l reaction mixture containing ... See full document
9
Cell Cycle Regulation of Human Interleukin-8 Gene Expression by the Human Immunodeficiency Virus Type 1 Tat Protein
... MG-132 treatment abolishes NF- B binding to the IL-8 promoter sequence as well as IL-8 protein synthesis. Since we demonstrated that the IL-8 promoter sequence is regulated by NF-B through the cell cycle, it was of ... See full document
8
Fruit-Specific Expression of the Human Immunodeficiency Virus Type 1 Tat Gene in Tomato Plants and Its Immunogenic Potential in Mice
... of Tat in plant ...of Tat with the coat protein of the tobacco mosaic virus and found that the construct induced severe systemic necrosis with stunting in Nicotiana benthamiana, causing the plants to ... See full document
8
Regulation of Human Immunodeficiency Virus Type 1 Gene Expression by Clade-Specific Tat Proteins
... of human immunodeficiency virus type 1 (HIV-1) strains that comprise the current global pandemic have diversified during their worldwide spread into at least 10 distinct ... See full document
12
Inhibition of human immunodeficiency virus type 1 replication by a Tat-activated, transduced interferon gene: targeted expression to human immunodeficiency virus type 1-infected cells.
... in Tat-mediated induction of HIV-1 LTR, unless activated during the course of Tat ...the Tat protein is unable to enhance expression of the p105 gene, which encodes the p105 ... See full document
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Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasm.
... HIV-1 Tat protein and its functional domains (19, 28, 41, 57, 58) are shown in ...of Tat. To evaluate the ability of the mutant Tat proteins to activate HIV gene expression and ... See full document
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Effects of the Tat basic domain on human immunodeficiency virus type 1 transactivation, using chemically synthesized Tat protein and Tat peptides.
... 3343-3353 0022-538X/94/$04.0 + Copyright © 1994, American Society for Microbiology Effects of the Tat Basic Domain on Human Immunodeficiency Virus Type 1 Transactivation, Using Chemicall[r] ... See full document
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Blockade of Human Immunodeficiency Virus Type 1 Expression by Caveolin-1
... of expression in the transfected cells relative to endog- enous expression in primary human cells that normally express Cav-1 (primary human vascular smooth muscle cells [VSMCs]) and in ... See full document
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