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[PDF] Top 20 MHCBN 4 0: A database of MHC/TAP binding peptides and T cell epitopes

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MHCBN 4 0: A database of MHC/TAP binding peptides and T cell epitopes

MHCBN 4 0: A database of MHC/TAP binding peptides and T cell epitopes

... Findings: MHCBN is a comprehensive database comprising over 25,857 peptide sequences (1053 TAP binding peptides), whose binding affinity with either MHC or TAP ... See full document

6

Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides

Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides

... [5]. T-cells targeting cancer cells can recognize antigens which can be classified into two broad ...in T-cell based therapies ...specific T-cells [7] or generate vaccines ...potent ... See full document

9

SVRMHC prediction server for MHC-binding peptides

SVRMHC prediction server for MHC-binding peptides

... on cell membranes. In the cellular immune system, MHC molecules bind small peptide fragments, or epitopes, derived from anti- gens and host proteins, and present them to T cells, thus inducing ... See full document

5

A hybrid approach for predicting promiscuous MHC class I restricted T cell epitopes

A hybrid approach for predicting promiscuous MHC class I restricted T cell epitopes

... predict MHC binding peptides with fair ...of MHC binders (Adams and Koziol ...the peptides as binders or non-binders in 78% of cases for HLA-A2 and 88% of cases for H-2Kb MHC ... See full document

12

Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides

Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides

... This binding modal- ity allows most MHCI molecules to present peptides of differ- ing lengths by accommodating the extra amino acids as a central “bulge” within the binding groove [10, ...these ... See full document

8

Identifying cytotoxic T cell epitopes from genomic and proteomic information: A. Fomsgaard. The human MHC project

Identifying cytotoxic T cell epitopes from genomic and proteomic information: A. Fomsgaard. The human MHC project

... that peptides are key targets of the immune ...peptide binding to MHC, making it particularly important to establish accu- rate descriptions and predictions of peptide binding for the most ... See full document

15

Identification of MHC Class II-restricted T-cell Epitopes in Prostate-specific Membrane Antigen 1

Identification of MHC Class II-restricted T-cell Epitopes in Prostate-specific Membrane Antigen 1

... peptide-specific T-cell clones because in-depth biological analysis would be not feasible without a peptide-specific T-cell ...of T-cell precursor frequency and the robustness of ... See full document

12

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

... immunogenic peptides, termed T cell epitopes, form ternary MHC II-peptide-T cell receptor complexes with cognate CD4 T cell surface receptors 7 ...in ... See full document

13

Identification and localization of minimal MHC restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

Identification and localization of minimal MHC restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

... peptide binding predictions were made for all alleles that matched the provided ...tide binding predictions were made for each allele, provided a predictor was ...10-mer peptides across different ... See full document

16

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

... peptide binding predictions were made for all alleles that matched the provided ...tide binding predictions were made for each allele, provided a predictor was ...10-mer peptides across different ... See full document

16

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

... peptide binding predictions were made for all alleles that matched the provided ...tide binding predictions were made for each allele, provided a predictor was ...10-mer peptides across different ... See full document

18

Identification of minimal human MHC restricted CD8+ T cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)

Identification of minimal human MHC restricted CD8+ T cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)

... peptide binding to class I MHC molecules is required for T cell recognition, many peptides that bind with high affinity are not recognized by T cells ...predicted epitopes ... See full document

17

Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)

Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)

... peptide binding to class I MHC molecules is required for T cell recognition, many peptides that bind with high affinity are not recognized by T cells ...predicted epitopes ... See full document

17

Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris

Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris

... of T-cell epitopes involves the three-dimensional modeling of peptide/MHC complexes using a hybrid docking approach that integrates the strengths of Monte Carlo simulations and homology ... See full document

11

SVRMHC prediction server for MHC-binding peptides

SVRMHC prediction server for MHC-binding peptides

... The class II SVRMHC model construction was more com- plicated than the class I case because the longer input sequences required alignment to the model's nonameric "core sequence". We took an approach similar to ... See full document

5

T cell recognition of endogenous and exogenous peptides presented by MHC molecules

T cell recognition of endogenous and exogenous peptides presented by MHC molecules

... patience. T hank professor Peter Beveley an d Av M itchison for their su p p o rt and good ...leasan t co-operation an d encouragem ...n t e n c o u ra g e m e n t a n d u se fu l ...y ... See full document

132

Building a Meta-predictor for MHC Class II Binding Peptides

Building a Meta-predictor for MHC Class II Binding Peptides

... Abstract Prediction of class II MHC-peptide binding is a challenging task due to variable length of binding peptides. Different computational methods have been developed; however, each has its ... See full document

16

TAP independent self peptides enhance T cell recognition of immune escaped tumors

TAP independent self peptides enhance T cell recognition of immune escaped tumors

... TEIPP T cells by vaccination with a syn- thetic long peptide. As TAP-deficient antigen-presenting cells effi- ciently primed LnB5 tg T cells in Tap1 –/– mice and endogenous TRH4 proteins in WT mice ... See full document

12

Immunodominant T-cell epitopes of rubella virus structural proteins defined by synthetic peptides.

Immunodominant T-cell epitopes of rubella virus structural proteins defined by synthetic peptides.

... Sets of overlapping synthetic peptides containing predicted T-cell epitope motifs were designed from the murine monoclonal antibody-defined map of linear B-cell epitope domains within ea[r] ... See full document

10

Tek and T Cell Epitopes

Tek and T Cell Epitopes

... and epitopes for which the IL-5 response was found to be particularly down- modulated in SIT and used it for additional studies in new donors ...and epitopes for their potential use in therapeutic ... See full document

6

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