[PDF] Top 20 Microtubule Reorganization during Herpes Simplex Virus Type 1 Infection Facilitates the Nuclear Localization of VP22, a Major Virion Tegument Protein
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Microtubule Reorganization during Herpes Simplex Virus Type 1 Infection Facilitates the Nuclear Localization of VP22, a Major Virion Tegument Protein
... synchronous infection by adsorption of the inoculum at 4°C is routine and has little or no effect on cells in ...of 1:10 for immu- nofluorescence and 1:50 for ...for VP22 has been described ... See full document
15
Fluorescent Tagging of Herpes Simplex Virus Tegument Protein VP13/14 in Virus Infection
... herpesvirus tegument assembly has yet to be ...binant herpes simplex virus type 1 expressing a green fluorescent protein (GFP)-tagged tegument protein, ... See full document
9
Modified VP22 Localizes to the Cell Nucleus during Synchronized Herpes Simplex Virus Type 1 Infection
... cytoplasmic VP22 did ...of VP22 coincides with its appearance in the ...herpesvirus type 1 VP22 homologue was also reported to exhibit a nuclear localization (27), it is ... See full document
13
Nuclear Localization and Shuttling of Herpes Simplex Virus Tegument Protein VP13/14
... The herpes simplex virus type 1 gene UL47 encodes the tegument proteins referred to collectively as VP13/14, which are believed to be differentially modified forms of the same ... See full document
9
Packaging Determinants in the UL11 Tegument Protein of Herpes Simplex Virus Type 1
... of herpes simplex virus type 1 encodes a 96-amino-acid tegument protein that is myristylated, palmitylated, and phosphorylated and is found on the cytoplasmic faces of ... See full document
8
Early, Active, and Specific Localization of Herpes Simplex Virus Type 1 gM to Nuclear Membranes
... its nuclear targeting. We found that the protein was detected on nuclear membrane invaginations and speckles early in infection at a time when other HSV-1 glycoproteins ...on ... See full document
14
Phosphorylation of the Herpes Simplex Virus Tegument Protein VP22 Has No Effect on Incorporation of VP22 into the Virus but Is Involved in Optimal Expression and Virion Packaging of ICP0
... for VP22 to be phosphorylated during virus infection for its correct subcellular targeting, we compared the localization of the phosphorylation variant G22P ⫺ and G22P ⫹ proteins with ... See full document
12
Distinctions between Bovine Herpesvirus 1 and Herpes Simplex Virus Type 1 VP22 Tegument Protein Subcellular Associations
... the VP22 homologs fused to GFP transfected into cell lines revealed fascinating contrasts between BVP22 and ...are VP22-transfected cells while nucleus-stained cells are VP22 trafficked cells ...only ... See full document
12
Herpes Simplex Virus Type 1 Tegument Protein VP22 Induces the Stabilization and Hyperacetylation of Microtubules
... reorganized during in- fection by HSV-1 ...such reorganization is related to the effects of VP22 on MTs observed during tran- sient expression, a time course of infection was ... See full document
8
Herpes simplex virus type 1 UL14 tegument protein regulates intracellular compartmentalization of major tegument protein VP16
... Background: Herpes simplex virus type 1 (HSV-1) has a complicated life-cycle, and its genome encodes many components that can modify the cellular environment to facilitate ... See full document
13
Virion Incorporation of the Herpes Simplex Virus Type 1 Tegument Protein VP22 Occurs via Glycoprotein E-Specific Recruitment to the Late Secretory Pathway
... of VP22 that is recruited by gE is already part of the assembling capsid at the time that it encounters the cyto- plasmic tail of ...after infection might suggest that the VP22-gE interaction occurs ... See full document
15
Identification of a Highly Conserved, Functional Nuclear Localization Signal within the N-Terminal Region of Herpes Simplex Virus Type 1 VP1-2 Tegument Protein
... structural protein assembled into the tegument compartment of the virion, conserved across the herpesviridae, and essential for virus ...In herpes simplex virus (HSV) and ... See full document
11
Deletion of the Herpes Simplex Virus VP22-Encoding Gene (UL49) Alters the Expression, Localization, and Virion Incorporation of ICP0
... in infection (2 h), there was little differ- ence in the characteristic nuclear localization patterns of ICP0 in either cell type infected with WT or ⌬ 22 virus ...the protein ... See full document
11
Nuclear Localizations of the Herpes Simplex Virus Type 1 Tegument Proteins VP13/14, vhs, and VP16 Precede VP22-Dependent Microtubule Reorganization and VP22 Nuclear Import
... have nuclear localization kinet- ics different from that of VP22, which are independent of HSV-1-induced microtubule ...these tegument proteins localized to the nucleus between 5 ... See full document
14
The Pattern of Tegument-Capsid Interaction in the Herpes Simplex Virus Type 1 Virion Is Not Influenced by the Small Hexon-Associated Protein VP26
... of protein called the tegument (7, ...In herpes simplex virus type 1 (HSV-1), the pentons and hexons contain five and six copies, respectively, of the 150-kDa ... See full document
5
Characterization of a CRM1-Dependent Nuclear Export Signal in the C Terminus of Herpes Simplex Virus Type 1 Tegument Protein UL47
... of infection of 5 with recombinant HSV-1 (strain 17) expressing yellow fluorescent protein (YFP)-tagged hUL47, which was described previously and behaves as wild-type virus ... See full document
7
Elucidation of the Block to Herpes Simplex Virus Egress in the Absence of Tegument Protein UL16 Reveals a Novel Interaction with VP22
... chaperone protein that becomes active only when cells are under oxidative stress ...and VP22 (this ...a virus- specific chaperone rather than simply providing bridging interac- tions ... See full document
10
Dual Function of the pUL7-pUL51 Tegument Protein Complex in Herpes Simplex Virus 1 Infection
... neither protein is able to localize to focal adhesions in the absence of the ...shape during HSV-1 ...of virus due to the small-plaque phenotype of pUL51 deletion viruses ...these ... See full document
19
Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.
... Infected-cell protein 4 (ICP4) is the major transcriptional activator of herpes simplex virus (HSV) gene expression during productive ...exhibit major transregulatory ... See full document
11
Herpes Simplex Virus Type 1 Glycoprotein E Is Required for Axonal Localization of Capsid, Tegument, and Membrane Glycoproteins
... retina infection model ...(Fig. 1). Retinas were stained with polyclonal HSV-1 antibody, which detects many viral pro- teins, including the ectodomains of gB, gC, gD, and gE ...body. Infection ... See full document
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