[PDF] Top 20 A Model of the Kinetics of Insulin in Man
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A Model of the Kinetics of Insulin in Man
... the kinetics of insulin in man combines experimental features which obviate two of the major problems in previous insulin ...radioiodinated insulin as a tracer has been shown to be ... See full document
13
Derivation of a three compartment model describing disappearance of plasma insulin 131I in man
... radioactive insulin were determined, and these data were analyzed in a variety of ...of insulin from plasma were calculated and found to be greatly diminished in patients with renal failure (t ½ = 39 min), ... See full document
10
Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp
... minimal model approach and the glucose clamp measure equivalent indices of insulin ...of insulin (I) infusion (15 and 40 mU/min per m2) in 10 subjects (body mass index, BMI, from 21 to 41 ...kg/m2). ... See full document
12
Human insulin B24 (Phe Ser) Secretion and metabolic clearance of the abnormal insulin in man and in a dog model
... abnormal insulin in which serine replaced phenylalanine B24 (Shoelson ...circulating insulin in several other family members also consists of a mixture of the abnormal human insulin B24 (Phe----Ser) ... See full document
9
Minimal Models for Glucose and Insulin Kinetics
... of Insulin Sensitivity and Glucose Effectiveness From the Minimal Model, Diabetes 42 (1993) ...Calculate Insulin Sen- sitivity and Pancreatic Responsivity from the Frequently Sampled Intravenous ... See full document
12
Insulin Control of Glucose Metabolism in Man: A New Kinetic Analysis
... smaller compartment (50±17 mg/kg) and in slow equilibrium with a larger compartment (96±21 mg/kg). The total plasma equivalent space for the glucose system averaged 15.8 liters or 20.3% body weight. Two modes of glucose ... See full document
11
Insulin responses to glucose: evidence for a two pool system in man
... rapid insulin response to a second glucose pulse (- 58%), but after a longer infusion (20 hr) the acute insulin response to a third pulse was restored to ...and insulin levels to prestudy base line ... See full document
12
Effect of insulin on the distribution and disposition of glucose in man
... exponential components were clearly identified in the plasma disappearance curves of tracer glucose of each subject studied, both before and after insulin. Based on stringent statistical criteria, the data in the ... See full document
9
Kinetics of glucose disposal in whole body and across the forearm in man
... in man is determined by the activity of the glucose transport ...four insulin levels (approximately 9, approximately 50, approximately 160, and approximately 1700 microU/ml) and at each insulin level ... See full document
8
Intramyocellular lipid kinetics and insulin resistance
... the kinetics of imcTG synthesis in the HFO model is greatly accelerated and it likely plays an important role in imcTG ...HFO model was not a result of direct (high fat) die- tary effects as plasma ... See full document
8
The Effect of Gastrin on Basal and Glucose Stimulated Insulin Secretion in Man
... of insulin in peripheral venous blood to a maximum within 2 min followed by a decline to basal levels after a further 10 ...significant insulin response ... See full document
13
Simultaneous Measurement of Thyroxine and Triiodothyronine Peripheral Turnover Kinetics in Man
... ) kinetics in man have been difficult to define presumably due to the interference of iodoproteins generated during the peripheral metabolism of T 3 ...4 kinetics were performed in 31 subjects from ... See full document
12
Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action
... plasma insulin concentration on muscle lipoprotein lipase activity (mLPLA), leg exchange of glucose, and serum lipoprotein levels were investigated in healthy young ...the insulin-induced increase in leg ... See full document
7
Effects of insulin on ovine fetal leucine kinetics and protein metabolism
... fetal insulin concentration affects fetal protein accretion and, if so, whether such changes are caused by effects on protein synthesis or protein ...leucine kinetics were measured by infusion of ... See full document
10
Effect of muscle glycogen depletion on in vivo insulin action in man
... increased insulin action. Whether this also occurs in man has not been ...plasma insulin congruent to 100 microU/ml and congruent to 1,900 microU/ml, with simultaneous indirect ... See full document
7
Defect in insulin binding to receptors in obese man Amelioration with calorie restriction
... unlabeled insulin was less effective in competing with labeled hormone for binding, both at low and high concentrations of unlabeled ...of insulin in the circulation of the obese patients at the time fthe ... See full document
10
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man
... clearance (CH2O) increased from 10.6 plus or minus 0.6 to 13 plus or minus 0.5 ml/min (P smaller than 0.025); osmolar clearance decreased and urine flow was unchanged. There was no change in plasma aldosterone ... See full document
12
Insulin increases glucose transfer across the blood brain barrier in man
... infused intravenously over 30 min while blood glucose was maintained constant by glucose infusion. Six determinations were made in each patient, two before, two during insulin infusion, and two after. In ... See full document
9
The effects of non insulin dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues
... of insulin resistance in non-insulin-dependent diabetes mellitus remains ill ...of insulin action, (b) impaired hepatic and extrahepatic kinetic responses to insulin, and (c) an alteration in ... See full document
9
Diurnal fluctuations in triglyceride, free fatty acids, and insulin during sucrose consumption and insulin infusion in man
... (FFA), insulin, and glucose have been measured in human subjects fed sucrose as the sole source of calories for 2- or 3-day ...subjects). Insulin was infused overnight in five additional subjects on the ... See full document
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