[PDF] Top 20 Modification of Nonstructural Protein 1 of Influenza A Virus by SUMO1
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Modification of Nonstructural Protein 1 of Influenza A Virus by SUMO1
... translational protein modifiers. The four SUMO paralogs in mammals, SUMO1 to -4, share high structural homology with ubiquitin and are covalently attached to target proteins in a similar fashion ...target ... See full document
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Epigenetic Modification Is Regulated by the Interaction of Influenza A Virus Nonstructural Protein 1 with the De Novo DNA Methyltransferase DNMT3B and Subsequent Transport to the Cytoplasm for K48-Linked Polyubiquitination
... WT virus and the PR8/delNS1 ...WT virus infection induced the expression of all regulators of JAK-STAT signaling, with the exception of SOCS2 and CD45 ...of virus titers, the expression of three ... See full document
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Visualizing the Beta Interferon Response in Mice during Infection with Influenza A Viruses Expressing or Lacking Nonstructural Protein 1
... Viral pathogens induce the synthesis of type I IFN and other cytokines by triggering pathogen recognition receptors (PRR) such as Toll-like receptors (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicases. ... See full document
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Hyperattenuated Recombinant Influenza A Virus Nonstructural-Protein-Encoding Vectors Induce Human Immunodeficiency Virus Type 1 Nef-Specific Systemic and Mucosal Immune Responses in Mice
... Recombinant influenza virus vectors expressing foreign antigens in the con- text of HA or NA described so far were mostly virulent in mice, since they replicated efficiently in murine respiratory tracts ... See full document
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A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate Immunity
... The EALQR motif is critical for inhibition of SeV-triggered RIG-I signaling. Since the influenza viruses we studied had clear phenotypic differences with respect to their ability to trigger the expression of IFNs in ... See full document
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Diagnostic Approach for Differentiating Infected from Vaccinated Poultry on the Basis of Antibodies to NS1, the Nonstructural Protein of Influenza A Virus
... of influenza virus ...live virus, commercial AI vaccine, or gradient-purified AI vaccines were tested for the presence or absence of specific antibodies to the NS1 ...collected 1 day before ... See full document
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Functional Analyses of the Three Simian Hemorrhagic Fever Virus Nonstructural Protein 1 Papain-Like Proteases
... duced in the SHFV in vitro autoprocessing reactions but were not detected in infected cells. Each of the SHFV nsp1 proteins is pre- dicted to contain multiple posttranslational modification motifs, including ... See full document
12
West Nile Virus Nonstructural Protein 1 Inhibits TLR3 Signal Transduction
... to virus infection including tumor necrosis factor alpha, IL-6, or monocyte che- motactic protein 1 (18, 21, 29, ...the virus. Influenza A virus infection in TLR3-deficient mice ... See full document
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Glycine 184 in Nonstructural Protein NS1 Determines the Virulence of Influenza A Virus Strain PR8 without Affecting the Host Interferon Response
... avian influenza A virus isolates revealed an invariable glycine residue at position 184 within the CPSF-binding ...PR8 virus, R/SI/G, showed efficient control of the IFN system in infected cell ... See full document
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Optimizing Viral Protein Yield of Influenza Virus Strain A/Vietnam/1203/2004 by Modification of the Neuraminidase Gene
... enza virus genes with genes derived from a high-growth donor strain, such as PR8, reassortant viruses can be generated that will facilitate the rapid production of the pandemic vaccines in a timely ...avian ... See full document
7
NS1-Binding Protein (NS1-BP): a Novel Human Protein That Interacts with the Influenza A Virus Nonstructural NS1 Protein Is Relocalized in the Nuclei of Infected Cells
... clear extracts was analyzed in the presence of GST–NS1-BP, GST-NS1, or control GST protein (Fig. 8). We also examined the formation of heparin-resistent splicing complexes in the same reactions by native gel ... See full document
11
SUMO1 Modification Facilitates Avibirnavirus Replication by Stabilizing Polymerase VP1
... polymerase protein VP1 is SUMOylated during avibirnavirus ...several virus life cycles ...the protein bands with different molecular weights, named as posttranslation modifications of VP1 ...capsid ... See full document
14
Influenza C virus RNA 7 codes for a nonstructural protein.
... Lanes: 1, mock-infected MDCK cells; 2, C/JJ/50 virus-infected MDCK cells; 3, in vitro translation products of mRNA preparation without prior hybridization to RNA 7-specific cDNA; 4, in v[r] ... See full document
6
SUMO Modification Stabilizes Dengue Virus Nonstructural Protein 5 To Support Virus Replication
... for protein SUMOylation, interacts with several dengue viral proteins (32, 34, ...SUMO modification pathway is involved in DENV replication, we suppressed the SUMOylation system by knocking down Ubc9 ... See full document
12
Double-Stranded RNA Binding of Influenza B Virus Nonstructural NS1 Protein Inhibits Protein Kinase R but Is Not Essential To Antagonize Production of Alpha/Beta Interferon
... type virus titers ...NS1-104 virus were 1 to 2 log units lower than those of the wild-type virus (Table ...NS1-104 protein supports viral replication and inhibition of PKR but not ... See full document
11
Expression of influenza virus NS2 nonstructural protein in bacteria and localization of NS2 in infected eucaryotic cells.
... Lane 1 and 7, AIPR/8/34 virus-infected CV-1 cell extract; lane 2, immunoprecipitation of mock-infected CV-1 cells; lane 3, immunoprecipitation of SVL2-801V-infected CV-1 cells; lane 4, i[r] ... See full document
11
Embryonic Cells Redistribute SUMO1 upon Forced SUMO1 Overexpression
... free SUMO1 in embryonic ...Flag-tagged SUMO1 and a drug resistance protein (PuroR) designed to be translated from a single bicistronic ...The SUMO1 gene was positioned at the 5= end of the ... See full document
13
Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A.
... Construction of HCV protein expression plasmids. The HCV polypeptide regions synthesized in COS-1 cells for this study are shown in Fig. 1. The construction of plasmids pCMV/N729-3010, ... See full document
7
Virus-Specific Cytolytic Antibodies to Nonstructural Protein 1 of Japanese Encephalitis Virus Effect Reduction of Virus Output from Infected Cells
... reducing virus production by infected ...limit virus production in infected human SW-13 cell mono- layers, which may explain, at least in part, the widely reported protective ability of flavivirus ...affect ... See full document
12
2′-5′-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1
... against virus infection is primarily mediated by type I interferons ...the virus has resulted in viral strategies to evade the host IFN response by targeting ISGs and other IFN pathway proteins ... See full document
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