[PDF] Top 20 Modulating mitophagy in mitochondrial disease
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Modulating mitophagy in mitochondrial disease
... 2 mitophagy by decreasing the expression of cytosolic p53 and increasing degradation of mitofusins ...of mitophagy, combining high content fluorescence microscopy and mitochondrial DNA load, we ... See full document
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Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection
... of mitochondrial quality control; but as mentioned earlier, PINK1 is also important for other aspects of mitochondrial ...son’s disease patients, transcripts of proteins involved in nucleotide ... See full document
9
Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease
... stress, mitochondrial dysfunction, or oxidative stress [42-44]. 'Mitophagy' was coined to describe the selective removal of mitochondria by autophagy during development and under pathologic condi- tions ... See full document
11
Curcumin a Multifaceted Compound with Hormetic Behaviour that Mediates an Intricate Crosstalk between Mitochondrial Biogenesis, Mitophagy, Mitophagic Death and Apoptosis
... elicit mitochondrial biogenesis in cells and tissues mainly through the well-known induction of the PGC-1 α -related signaling pathway [201, ...triggered mitochondrial biogenesis remains to be fully ... See full document
44
Effect of exercise training intensity on mitochondrial dynamics and mitophagy in post myocardial infarction rats
... via mitophagy process, employing the autophagosome ...levels mitochondrial biogenesis were ...of mitochondrial biology could be affected by exercise training and has a vital role in cardiomyocyte ... See full document
10
ALZHEIMER’S DISEASE: A CONSEQUENCE OF IMPAIRED MITOPHAGY?
... include mitochondrial biogenesis and fusion and fission. Mitophagy is an utmost requirement for degradation and removal of damaged mitochondria where the target mitochondria are identified by the ... See full document
6
Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin
... detected mitophagy deficits evidenced by the increased levels of mitophagy markers, including COX IV, TOMM20, and the ratio of mtDNA to genomic DNA indexed as mt-Atp6/Rpl13, in the AD brains and in the ... See full document
13
Original Article Polydatin prevents Aβ-induced neuron cytotoxicity via enhancing autophagy and decreasing oxidative stress
... Alzheimer’s disease (AD). Aβ leads to increased oxidative stress and mitochondrial damage of neuron ...preliminary mitochondrial autophagy was assessed by western blot analysis of the loss of ... See full document
10
Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis
... Newcastle disease virus [38] have been confirmed to subvert mitophagy to facilitate their own ...Parkin-dependent mitophagy (Figure ...virus-induced mitophagy, which exclude the role of Parkin ... See full document
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RETRACTED ARTICLE: LATS2 overexpression attenuates the therapeutic resistance of liver cancer HepG2 cells to sorafenib-mediated death via inhibiting the AMPK–Mfn2 signaling pathway
... the mitochondrial apoptosis pathway to promote cancer ...to mitochondrial damage, mitochondria themselves would initiate the repair sys- tem to correct excessive mitochondrial injury, which is termed ... See full document
15
Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission
... FA mitochondrial damage? To answer that part, a cybrid technology can be applied ...(ATM) disease suggest that these events are not necessarily coupled as MDF- mediated ATM activation may take place without ... See full document
10
The role of mitochondria in stem cell fate and aging
... exhibit mitochondrial FAO as a mechanism for self-renewal and resistance to chemotherapy (Chen et ...of mitochondrial FAO and glycolysis might play a role in self- preservation in some types of ...own ... See full document
13
Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations
... activated mitophagy may increase turnover of mitochondria and ...2E). Mitophagy may be exces- sive in retinal ganglion cells of OPA1 patients, perhaps increasing demand on lysosomal pathways or causing ... See full document
13
Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control
... A full-length FLAG-tagged DJ-1 sequence was cloned into the KpnI and XhoI sites of the pcDNA3.1 + vector to generate pcDNA3-FLAG-DJ-1. The DJBP cDNA encoding the 570 amino acid isoform (AB073862) was amplified from human ... See full document
15
Selective Mitophagy in Budding Yeast, a Mitochondrial Self-Eating Quality Control
... a mitochondrial receptor protein and during mitophagy it binds to the Atg11 (and adaptor protein) [19, ...novel mitophagy receptor protein during the screening of genome of mutant yeast that is ... See full document
12
Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress
... A recognized role for REDD1 is the inhibition of the Akt/mTORC1 pathway through TSC2 activation [30] or Akt inhibition [31]. Consistently, recent studies have demonstrated that REDD1 is required for mTORC1-dependent ... See full document
17
The Mitochondrial Dnm1-Like Fission Component Is Required for lga2-Induced Mitophagy but Dispensable for Starvation-Induced Mitophagy in Ustilago maydis
... of mitochondrial fission in lga2-triggered mi- ...of mitochondrial fission, using ...(ⱕ3% mitophagy in two independent ⌬dnm1 mutants analyzed) ...the mitochondrial surface (26, 33, 34, ...of ... See full document
13
Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis
... the mitochondrial population to apoptosis signaling by reducing the level of cytochrome c release in a sub-population of ...the mitochondrial population. We show that increasing mitochondrial ... See full document
23
Mitochondrial Deficiencies and Oxidative Stress in Parkinson's Disease: A Slippery Slope to Cell Death
... impair mitochondrial function and lead to apoptosis and rapid generation of reactive oxygen species (ROS; Dauer and Przedborski, ...the mitochondrial disease pathway is ... See full document
8
Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn’s disease
... Case presentation: A 25-year-old female presented with diarrhoea, vomiting, abdominal pain, and bloating. Faecal calprotectin, colonic biopsies and magnetic resonance enterography were consistent with a diagnosis of ... See full document
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