[PDF] Top 20 Modulation of HIV 1 host interaction: role of the Vpu accessory protein
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Modulation of HIV 1 host interaction: role of the Vpu accessory protein
... Vpu protein with mutations of the two phosphoserines involved in the recruitment of b-TrCP did not show any evidence of CD4+ T cell depletion and maintained signif- icantly lower viral loads than macaques ... See full document
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Sequences in Gibbon Ape Leukemia Virus Envelope That Confer Sensitivity to HIV-1 Accessory Protein Vpu
... 2011 HIV-1 efficiently forms pseudotyped particles with many gammaretrovirus glycoproteins, such as Friend murine leukemia virus (F-MLV) Env, but not with the related gibbon ape leukemia virus (GaLV) Env or ... See full document
11
Comparison of the HIV-1 VPU interaction with CD4 and CD74
... 30 Vpu modulates surface expression of the mature MHCII molecules by interacting with CD74 within the ...whether Vpu only mediates downregulation of MCHII by retention of the immature complex within the ER ... See full document
122
The role of Vpu-mediated tetherin antagonism in HIV-1 fitness
... pandemic HIV-1 group M and closely related but less successful pathogens helps to expose viral vulnerabilities, which can be exploited as targets of new treatment or preventive ...distinguishes ... See full document
104
Viral replication is enhanced by an HIV 1 intersubtype recombination derived Vpu protein
... alternative protein form with enhanced regulation capacity of the host cell ...and interaction with the host immune system ...important role in the successful spread of the resulting ... See full document
9
The HIV 1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells
... cell protein interactions are critical for Nef‑mediated CD28 downregulation To further elucidate the mechanisms used by Nef to down- regulate CD28, we sought to determine if this function is dependent on motifs ... See full document
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HIV 1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic intervention
... about HIV-1 ...critical role in the infection of non-dividing target cells includ- ing macrophages and resting ...of host and viral ...of HIV-1 infection as well as asso- ciated ... See full document
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Oligomerization of the human immunodeficiency virus type 1 (HIV 1) Vpu protein – a genetic, biochemical and biophysical analysis
... that Vpu can form oligomers ...of Vpu [23]. The oligomeric nature of Vpu is also likely to affect its interaction with cellular proteins and therefore its role in HIV-1 ... See full document
11
Modulation of β-Catenin and E-Cadherin Interaction by Vpu Increases Human Immunodeficiency Virus Type 1 Particle Release
... 2008 Vpu (viral protein U) is a 17-kDa human immunodeficiency virus type 1 (HIV-1) accessory protein that enhances the release of particles from the surfaces of infected ... See full document
7
HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites
... physical interaction of Vpu with ...enables Vpu to bind to adaptor protein 1 (AP-1) trafficking complexes via two independent interaction motifs and to couple ... See full document
15
Transmembrane Domain Determinants of CD4 Downregulation by HIV-1 Vpu
... of Vpu exists in equilibrium between monomeric and oligomeric forms, which are active and inactive, respectively, for CD4 targeting to the ERAD ...pathway. Vpu Trp22 helps main- tains Vpu in its ... See full document
16
Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs
... Previous host-pathogen interaction prediction methods focused largely on finding PPIs between human and cellu- lar parasite ...two protein domains interact given the human PPI network, and used this ... See full document
13
Vpu Is the Main Determinant for Tetraspanin Downregulation in HIV-1-Infected Cells
... The HIV-1 accessory protein Vpu has previously been shown to downregulate various host cell factors, thus helping the virus to overcome restriction barriers, evade immune attack, ... See full document
9
Functional Interaction of Human Immunodeficiency Virus Type 1 Vpu and Gag with a Novel Member of the Tetratricopeptide Repeat Protein Family
... Viral protein U (Vpu) is a protein encoded by human immunodeficiency virus type 1 (HIV-1) that promotes the degradation of the virus receptor, CD4, and enhances the release of ... See full document
11
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response
... To further investigate the IFN inhibition activity of ORFX, the deletion mutant and wild-type recombinant virus were used to infect Calu-3 cells at an MOI of 5. Mock-infected cells were used as negative control. Calu-3 ... See full document
10
Host virus interaction: a new role for microRNAs
... for HIV-1 encoded microRNAs and further went about pre- dicting their cellular targets and found five pre-miRNA candidates which has potential to encode 10 microRNAs and through them regulate ~1000 ... See full document
9
Virus producing cells determine the host protein profiles of HIV 1 virion cores
... these host proteins relative to the sites of virion assembly in dif- ferent cell types and/or with different localization of virion assembly ...The host factors abundant in the viral cores may play a ... See full document
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Vpu Mediated Counteraction of Tetherin Is a Major Determinant of HIV 1 Interferon Resistance
... allowed HIV-1 to cause the AIDS pandemic is of great impor- ...pandemic HIV-1 group M strains from nonpandemic or rare group O, N, and P viruses is the acquisition of mutations in the ... See full document
10
Modulation of microtubule assembly by the HIV 1 Tat protein is strongly dependent on zinc binding to Tat
... the role of zinc in the molecular mechanism of Tat-induced apoptosis, we ana- lyzed the conformations of the apo-form and zinc-bound form of Tat, and studied the interaction of the two forms of Tat with ... See full document
13
Identification of Amino Acids in the Human Tetherin Transmembrane Domain Responsible for HIV-1 Vpu Interaction and Susceptibility
... for Vpu bind- ...the Vpu-hu-tetherin ...in Vpu that interact with the three amino acid resi- dues found in this ...the Vpu TM residues contributing to tetherin ...sequester Vpu while ... See full document
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