[PDF] Top 20 A multiplex platform for the identification of ovarian cancer biomarkers

... stage ovarian cancer patients clustered together (right cluster, ...stage ovarian cancer, as depicted by red squares in the upper right quadrant of ...with ovarian cancer, such ... See full document

... OvCa: Ovarian cancer; WGCNA: Weighted gene co-expression network analysis; OS: Overall survival; PFS: Progression-free survival; GEO: The Gene Expression Omnibus; DEGs: Different expression genes; TOM: ... See full document

... miRNA biomarkers were closely implicated in cancer progression-related processes, such as transcriptional regulation, morphogenesis, and cell migration and pro- liferation ... See full document

... Data were analysed using OpenMetaAnalyst (open-source, cross-platform software for advanced meta-analysis), Stata statistical software (v.14.0; Stata Corp, USA) and RevMan 5.3 (Cochrane Collaboration, Oxford, UK). ... See full document

... for cancer biomarkers such as PSA (prostate cancer), CA-125 (ovarian cancer), and HER2/neu (breast ...the cancer biomarker field since this bio-fluid is obtained noninvasively ... See full document

... diagnosing ovarian (Petricoin et al, 2002; Kozak et al, 2003), prostate (Adam et al, 2002; Qu et al, 2002; Banez et al, 2003), breast (Li et al, 2002), bladder (Vlahou et al, 2001), hepatic (Poon et al, 2003; Ward ... See full document

... of cancer-associated pro- teins in human urine and ...with ovarian cancer and benign ovarian tumors, Hüttenhain et ...prostate cancer patients and controls, and used the resulting ... See full document

... DNA platform was made depending on the quality and quantity of avail- able DNA and both methods analyzed the same genomic ...of biomarkers can be found in Table 1 ... See full document

... peptide identification into pro- tein groups and to show protein-based ratios of relative ...in ovarian cancer relative to non-cancer control sera if the iTRAQ ® ratio of C/N ... See full document

... serous cancer, but lack diagnostic power for early stage and the less common ovarian adenocarcinomas, especially mucinous can- ...of ovarian malignancy algorithm (ROMA) is based on CA125, HE4 and ... See full document

... With the exception of proteins and miRNAs, several bio-active molecules such as phosphatidyl-serine (PS), DNAs, glycans, and glycoprotein [44], have been re- ported to play an important role in exosome internaliza- tion, ... See full document

... breast cancer subtypes, the more important the isomiR for breast cancer subtype ...isomiR biomarkers for classification of the different breast cancer ...breast cancer subtyping in ... See full document

... of ovarian cancer, attention has been increasingly focused on trabectedin (ET-743), a drug which displays a unique mecha- nism of action and has been shown to be active in several human ... See full document

... lung cancer related genes, a comprehensive assortment of signal transducers involved in the signaling of tumor cells, or even to the entire exome or genome of tumor ...molecular biomarkers for early ... See full document

... HCC is one of the most common malignancies worldwide with an increase in incidence. 1,2 Currently, the most widely used diagnostic methods for HCC screen- ing include biannual abdominal ultrasound examination and serum ... See full document

... pancreatic cancer and healthy individuals with a sensitivity of ...to biomarkers in PC, recent investigations [10,11] on glypican 1 (GPC1) circulating exosomes show promise as potential biomarkers in ... See full document

... preclinical ovarian tumour sizes, [44] suggested that achieving a 50% sensitivity in tumour detection before tumours reached advanced stages would require the detection of tumours of ...immune biomarkers ... See full document

... The present meta-analysis showed that the pooled charac- teristics were as follows: SEN of 0.67, SPE of 0.782, PLR of 3.08, and NLR of 0.39. The results indicated that the diagnos- tic accuracy may not be high enough as ... See full document

... regulation of growth. In particular, many of these enriched functions regulated by hub miRNAs participate in the for- mation and progression of multiple tumors. For instance, the MAPK cascade is a critical pathway for ... See full document

... cervical cancer have been carried out to identify the differ- entially expressed genes (DEGs) related to the develop- ment process or prognosis of ...to cancer research, and a large amount of valuable ... See full document