[PDF] Top 20 Mumps Virus V Protein Antagonizes Interferon without the Complete Degradation of STAT1
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Mumps Virus V Protein Antagonizes Interferon without the Complete Degradation of STAT1
... cellular STAT1 levels as well as sensitivity to IFN- ␣ , at least at certain levels ...of STAT1 degradation in the cells ex- ...-induced STAT1 phosphorylation at Y 701 ... See full document
9
The V Protein of Mumps Virus Plays a Critical Role in Pathogenesis
... The V protein of MuV has 224 amino acid residues and contains a cysteine (Cys)-rich C terminus that is conserved among all ...The V protein in- terrupts the interferon (IFN) signaling ... See full document
9
Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1
... IFNAR1 protein to be degraded by IAV infec- tion, the antiviral activities of WT and mutant IFNAR1 were an- alyzed at 60 ...pSTAT1, STAT1, pSTAT2, STAT2, ISG56, OAS1, and GAPDH was analyzed at 24 hpi ... See full document
15
The p127 Subunit (DDB1) of the UV-DNA Damage Repair Binding Protein Is Essential for the Targeted Degradation of STAT1 by the V Protein of the Paramyxovirus Simian Virus 5
... the V proteins encoded by simian virus 5 (SV5), mumps virus, and SV41 block IFN signaling by targeting STAT1 for degradation (7, 24, 32), while the V protein of ... See full document
8
C-Terminal Region of STAT-1α Is Not Necessary for Its Ubiquitination and Degradation Caused by Mumps Virus V Protein
... with mumps virus ...accessory protein V ...of V protein (Vc189a, Vc207a, and Vc214a) showed that each cysteine residue plays an important role in the decrease in STAT-1 ... See full document
9
STAT3 Ubiquitylation and Degradation by Mumps Virus Suppress Cytokine and Oncogene Signaling
... of mumps virus per cell and stained with mumps virus NP antibody (Chemicon International; 10 ...that V protein effects on STATs were observed with 100% penetration, even in cells ... See full document
9
Selective STAT Protein Degradation Induced by Paramyxoviruses Requires both STAT1 and STAT2 but Is Independent of Alpha/Beta Interferon Signal Transduction
... STAT protein subunits. The paramyxovirus simian virus 5 (SV5) was found to evade IFN responses by specifically targeting the STAT1 protein for proteolytic ...of STAT1 was found to be ... See full document
9
Association of Mumps Virus V Protein with RACK1 Results in Dissociation of STAT-1 from the Alpha Interferon Receptor Complex
... with mumps virus (MuV) has been reported (7, 12, ...simian virus 5 structural protein V induces the proteosome-mediated degradation of STAT-1␣ ...structural protein ... See full document
7
Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response
... . ***, P ⬍ 0.001. FIG 3 PRV UL50 blocks the IFN- ␣ -induced phosphorylation and nuclear accumulation of STAT1. (A) CRL cells were transfected with E.V or with 1 g of plasmid expressing Flag-tagged PRV UL50 or ... See full document
17
Rabies Virus P Protein Interacts with STAT1 and Inhibits Interferon Signal Transduction Pathways
... STAT protein function in many cases by using a phosphoprotein P gene product ...Rubulavirus V proteins (SV5 and mumps) block IFN by inducing STAT1 degradation (35, ...Sendai ... See full document
10
Degradation of STAT1 and STAT2 by the V Proteins of Simian Virus 5 and Human Parainfluenza Virus Type 2, Respectively: Consequences for Virus Replication in the Presence of Alpha/Beta and Gamma Interferons
... The V protein of SV5 targets STAT1 for proteasome- mediated degradation and is thus responsible for the observed block in IFN signaling ...The V protein of mumps ... See full document
9
Hepatitis C Virus Core Protein Blocks Interferon Signaling by Interaction with the STAT1 SH2 Domain
... proteasome-mediated degradation by mumps protein V (40). Rabies virus P protein has been re- ported to interact with STAT1 and blocks the IFN signaling pathway ...rabies ... See full document
10
Interaction of mumps virus V protein variants with STAT1 STAT2 heterodimer: experimental and theoretical studies
... to interferon is higher than in the presence of an infection with the variant HN-A1081 (VWT) ...the degradation of STAT1 protein for the variant VGly are conferred by inefficient interaction ... See full document
10
The V Protein of Simian Virus 5 Inhibits Interferon Signalling by Targeting STAT1 for Proteasome-Mediated Degradation
... the V protein of SV5 remains to be established but seems ...not V, that counteract the IFN-induced anti-viral state (SV5 and other rubulaviruses do not encode the C ...the V protein of ... See full document
6
A Point Mutation, E95D, in the Mumps Virus V Protein Disengages STAT3 Targeting from STAT1 Targeting
... of virus infection by the generation of a recom- binant mumps virus harboring the ...the V pro- teins of other rubulaviruses, that of the mumps virus is en- coded by an mRNA ... See full document
10
Inhibition of Interferon Signaling by Rabies Virus Phosphoprotein P: Activation-Dependent Binding of STAT1 and STAT2
... of STAT1 and STAT2 by RV P to interrupt IFN JAK-STAT signaling is unique among ...tial V proteins (for review see references 13, 14, 18, and 29). Rubulavirus V proteins assemble STAT-specific ... See full document
9
Modulation of apoptosis by V protein mumps virus
... DNA degradation and phagocytosis of apoptotic bodies ...of mumps virus is V protein expression required to blocking the expression of viral genes acti- vated by IFN through cytoplasmic ... See full document
7
Identification of Paramyxovirus V Protein Residues Essential for STAT Protein Degradation and Promotion of Virus Replication
... their V and W proteins have been recovered, and all these viruses grow similarly to their respective wt virus at least in some cell lines, ...nonmammalian virus, was previously clas- sified as a ... See full document
11
Nipah Virus V Protein Evades Alpha and Gamma Interferons by Preventing STAT1 and STAT2 Activation and Nuclear Accumulation
... G. STAT1 and STAT2 polyclonal antisera used for immunofluorescence were precleared on fixed and permeabilized STAT1-deficient U3A cells or STAT2- deficient U6A cells to reduce nonspecific background ... See full document
8
Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Antagonizes Beta Interferon Expression by Targeting the NF-κB Essential Modulator
... control virus infection in the early phase but also to facilitate viral clearance by the adaptive immune system (41, ...I interferon responses by PRRSV may be involved in its pathogenesis ... See full document
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