[PDF] Top 20 Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy
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Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy
... EGFR mutations in a relatively small study size of 70 triple negative breast can- cers in a Singapore population (8 of 70 ...erlotinib therapy in triple negative ... See full document
9
Epidermal growth factor receptor (EGFR) gene alteration and protein overexpression in Malaysian triple-negative breast cancer (TNBC) cohort
... geted therapy against metastatic TNBC came from the European Society of Medical Oncology which reported a 20% response in patients with metastatic TNBC receiving Cetuximab in combination with Cisplatin opposed to ... See full document
10
The Role of Epidermal Growth Factor Receptor in Cancer and their Application for New Targeted Cancer Therapy
... the receptor is targeted with some FDA approved drugs as Epidermal Growth Factor Receptor Inhibitor (EGFRI) and Tyrosine Kinase Inhibitor (TKI) ...modulates growth, ... See full document
6
Combating Resistance To Epidermal Growth Factor Recpetor Inhibitors In Triple Negative Breast Cancer
... The receptor c-Met (MNNG HOS transforming gene) is overexpressed in NSCLCs that are resistant to EGFR ...in breast cancer resistance to EGFR TKIs, as it was found to activate EGFR substrates ... See full document
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Epidermal growth factor receptor (EGFR) overexpression in triple-negative breast cancer: association with clinicopathologic features and prognostic parameters
... Triple-negative Breast Cancers (TNBC) are a poor prog- nostic group of breast cancers and accounts for 20% of human breast cancers (Swain, 2008; Nakai et ...Estrogen Receptor ... See full document
7
Cancer therapy target: the epidermal growth factor receptor
... T Epidermal growth factor receptor (EGFR) signaling plays an essential role in cell proliferation, survival, and ...pathways. Mutations in EGFR which lead to ligand independent and/or ... See full document
8
Epidermal growth factor receptor in breast carcinoma: association between gene copy number and mutations
... EGFR gene mutations were rare in breast carcinomas, but EGFR gene amplification was detected in about one third of the cases in this popula- ...rare mutations in the EGFR gene in ... See full document
9
Prognostic Implications of Epidermal Growth Factor Receptor and KRAS Gene Mutations and Epidermal Growth Factor Receptor Gene Copy Numbers in Patients with Surgically Resectable Non-small Cell Lung Cancer in Taiwan
... the therapy was performed in another ...EGFR mutations (six were L858R, four were exon 19 deletion, and one was L858R ⫹ E709G), and one had no EGFR mutation ... See full document
10
<p>Epidermal growth factor receptor (<em>EGFR</em>) gene alteration and protein overexpression in Malaysian triple-negative breast cancer (TNBC) cohort</p>
... the gene ampli fi cation variation, EGFR muta- tional analyses revealed no EGFR mutations in European population but about 0% and 11% mutation frequency in French and Chinese population, ...between ... See full document
8
Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer.
... the epidermal growth factor receptor (EGFR) have expanded the range of treatment options for metastatic colorectal ...suppressor gene is central to the progression of colorectal ...KRAS ... See full document
17
Original Article Temozolomide and targeted therapy against epidermal growth factor receptor in glioma
... EGFR gene mutations) in low grade gliomas or the fact that tumours tend to be ...The growth factor receptor (GFR) targeted agents, on the other hand, act by mechanisms that ... See full document
13
Biomarkers predicting resistance to epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer with wild-type KRAS
... anti-EGFR therapy Tumors sensitive to anti-EGFR therapy would eventually develop resistance to this ...this therapy is critical to guide-personalized therapy and reverse drug ...KRAS ... See full document
9
Down regulation of SPAG9 reduces growth and invasive potential of triple-negative breast cancer cells: possible implications in targeted therapy
... Endogenous SPAG9 protein expression was validated in all normal mammary epithelial cells and breast cancer cells by Western blot analysis. Cell lysates were prepared in lysis buffer [(1.5 mM Tris–HCl, pH ... See full document
11
A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics.
... Triple-negative breast cancers (TNBCs), defined by the lack of oestrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor ... See full document
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Advances in therapy of breast cancer: overexpression and therapeutic implications of targeting human epidermal growth factor receptors
... positive breast cancers, demonstrating dramatic responses in patients with metastatic ...the epidermal growth factor receptor family have led to the identification of newer agents, ... See full document
6
Original Article C-kit and PDGFRA gene mutations in triple negative breast cancer
... derived growth factor receptor A (PDGFRA) gene mutations in triple negative breast ...C-kit negative cases and 35 C-kit positive cases, were performed for ... See full document
6
Triple-negative breast cancer: new perspectives for targeted therapies
... Abstract: Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical ...of gene-expression microarray-based ... See full document
17
Treatment of pancreatic cancer with epidermal growth factor receptor-targeted therapy
... The epidermal growth factor receptor (EGFR) is a commonly expressed target in pancreatic cancer that is involved in tumor proliferation, metastasis, and induction of ... See full document
10
The epidermal growth factor receptor family in breast cancer
... human epidermal growth factor receptor (HER) family comprises four homologous members: EGFR, HER-2, HER-3, and ...in breast cancer ...of breast cancer ...tumor ... See full document
16
Complex Mutations in the Epidermal Growth Factor Receptor Gene in Non-small Cell Lung Cancer
... single mutations, with only a few complex mutations being ...complex mutations was ...EGFR mutations has been demonstrated in recent clinical ...EGFR mutations were 70 to 80%, and mPFS ... See full document
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