[PDF] Top 20 A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis
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A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis
... possible tissue-specific processes that contribute to disease in the internal ...into tissue-specific functional networks using big data machine-learning strategies ...dressed tissue ... See full document
24
Propylthiouracil prevents cutaneous and pulmonary fibrosis in the reactive oxygen species murine model of systemic sclerosis
... Although thyroid-function alterations [10-14,43] are fre- quently reported in SSc patients, our data suggest that PTU exerts an antioxidant effect, consistent with pre- vious reports [31-33,36,37], abrogating the ... See full document
12
Ophthalmic Findings in Systemic Sclerosis and Its Association with Dermal Fibrosis
... in Systemic Sclerosis (SSc) and to establish their association with the extent and severity of cutaneous ...ous Systemic Sclerosis (lcSS) and diffuse cutaneous Systemic Sclerosis ... See full document
9
European multicentre study validates enhanced liver fibrosis test as biomarker of fibrosis in systemic sclerosis.
... Systemic sclerosis (SSc) is characterised by tissue fibrosis whose pathogenesis is partially elucidated ...overall fibrosis and fibrogenesis has been an unmet need for long time and ... See full document
17
Anti connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis
... Background: Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal ...connective tissue growth factor (CTGF/CCN2) has been well-documented in SSc fibrosis, the ... See full document
10
miR 155 in the progression of lung fibrosis in systemic sclerosis
... diffuse systemic sclerosis; H&E, hematoxylin and eosin; FDR, false discovery rate; FiBMax, high-resolution computed tomography lung score; HRCT, high-resolution computed tomography; IFN, interferon ... See full document
13
DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models
... induced tissue injury by inhibiting the differentiation of T cells such as Th1, Th2, and Th17 ...pathological fibrosis partly by inhibiting macro- phage differentiation into M1 and M2 ... See full document
15
Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional, clinical and radiological signs of lung fibrosis
... ceral fibrosis remain mostly ...lung fibrosis, which assigns only a marginal role to inflammation, fibrogene- sis in SSc-related lung involvement is generally thought to be the result of a complex series of ... See full document
11
Interstitial lung disease in systemic sclerosis: where do we stand?
... with the TGF- β pathway since it inhibits Smad 3 phosphorylation and increases the endocytosis and degradation of TGF- β ligand – receptor complexes. In SSc patients, low levels of surface caveolin-1 have been detected ... See full document
9
Increased Levels of Alternatively Spliced Interleukin 4 (IL-4δ2) Transcripts in Peripheral Blood Mononuclear Cells from Patients with Systemic Sclerosis
... emerging as a major fibrogenic cytokine. First, it induces col- lagen production by fibroblasts in vitro (20, 28). Second, over- expression of IL-4 in transgenic mice under the control of the insulin promoter in ... See full document
5
Tie2 as a novel key factor of microangiopathy in systemic sclerosis
... Background: The angiopoietin(Ang)/Tie2 system is a key regulator of vascular biology. The expression of membrane bound (mb) Tie2 and Ang-1 ensures vessel stability, whereas Ang-2, inducible by vascular endothelial growth ... See full document
11
A Study of Cardio Pulmonary Manifestations in Systemic Sclerosis
... in fibrosis and significant alteration of the pulmonary ...connective tissue growth factor [CTGF]) are elevated in SSc BAL fluid and may play a role in the pathogenesis of ILD in ... See full document
110
Abstract
... Many investigators consider that endothelial damage could be the earliest lesion in systemic sclerosis. The first clinical manifestations of vas− cular dysfunction are Raynaud’s phenomenon and abnormal ... See full document
6
Cardiovascular magnetic resonance imaging: clinical implications in the evaluation of connective tissue diseases
... and fibrosis. Rheumatoid arthritis and other spondyloarthropathies, systemic lupus erythematosus, inflammatory myopathies, mixed connective tissue diseases (CTDs), systemic sclerosis, ... See full document
7
Comprehensive Analysis of 20 Cases of Systemic Sclerosis
... pulmonary fibrosis due to scleroderma should be classified as mild, moderate, and severe when the measures of DLCO and FVC are 70-79%, 50-60%, and less than 50% of the predicted ... See full document
151
Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis
... We explored short-range SNP-CpG associations around a selected subset of CpG-based DMR identified in the com- parison between SSc cases (N = 9) versus female controls (N = 4) that could be deemed consequential for SSc. ... See full document
12
Effect of ivacaftor on mucociliary clearance and clinical outcomes in cystic fibrosis patients with G551D-CFTR
... the systemic route pro- vides an important efficacy advantage over inhaled ...of systemic therapies and improvements in the delivery of inhaled therapeutics to small airways may be a key component to ... See full document
11
Off-label use of tocilizumab to treat non-juvenile idiopathic arthritis in pediatric rheumatic patients: a literature review
... SLE is a systemic autoimmune disease involving the skin, joints, kidneys, and other organs via autoantibody produc- tion and the formation of immune complexes. Childhood- onset SLE is rare (0.3–0.9/100,000 ... See full document
9
Detection of a novel circovirus PCV3 in pigs with cardiac and multi systemic inflammation
... by specific testing leaving the causa- tive agent(s) ...a systemic blood infection and in combination with other infectious agents such as PCV3, as was the case for all 3 animals here, is also a credible ... See full document
8
Regional grafting of autologous adipose tissue is effective in inducing prompt healing of indolent digital ulcers in patients with systemic sclerosis: results of a monocentric randomized controlled study
... contribution given by the SVF in the regenerative effects that whole AT has shown under many different conditions [35]. Recent studies have demonstrated that pericytes pos- sibly provide a very important contribution to ... See full document
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