[PDF] Top 20 Nortriptyline in knee osteoarthritis (NortIKA Study): study protocol for a randomised controlled trial

... start study medication at a dose of 1 cap- sule at ...the study drug: participants will be asked whether they have experienced any change in their knee pain and whether they have experienced adverse ... See full document

... Depression and anxiety scores will be analysed in terms of change from baseline. For each group, the mean change in the score will be compared with zero by the one-sample t-test. The effect of treatment will be evaluated ... See full document

... the knee; (iii) have suspected tears in any ligaments or menisci or acute inflammation of the synovial capsule; (iv) have a history of trauma, ligament damage, fracture, or surgery on the knee(s) within 6 ... See full document

... We will use two ways of recruiting participants: either a member of the orthopaedic clinical team will identify potential participants at the point of listing for TKA and will send out an invitation letter and ... See full document

... The analyses will be conducted on an intention-to- treat basis with and without imputation of missing pri- mary outcome data. A multiple imputation (MI) by chained equations under a missing at random frame- work ... See full document

... randomized controlled trials are needed to examine the efficacy of TCM treat- ments for ...present trial is an external placebo control. The purpose of this study will be to evaluate the basic ... See full document

... In this session, the participants will receive background knowledge of OA, including pathogenesis, risk factors, clin- ical manifestations, pharmacological therapies and progno- sis of OA. Besides, some feasible ... See full document

... The data will be collected and analyzed according to the intention-to-treat principle. An analysis of variance (ANOVA) or chi-square test will be used to compare baselines among patients. Efficacy analyses will be per- ... See full document

... any protocol deviation and developing a model for the probability of deviation, followed by weighted analyses using only the uncen- sored participants where the weights are the inverse probability of ...the ... See full document

... Both between and within groups, the numerical variables include the clinical data collected from the VAS, the short form of the McGill Pain Questionnaire, the WOMAC, ATS, SAS, SDS, PAS, deqi scale and the SF-12 scale, ... See full document

... reduce knee pain, improve physical function and quality of life in subjects with knee OA ...with knee OA is not well known. In a previous study, Toda [29] reported worsening of symptoms ... See full document

... the trial is evaluating two different undis- closed “classes” of footwear to compare effects on knee OA ...the study hypotheses, or which group they are allocated to until the study is com- ... See full document

... Data will be input into an electronic case report form (eCRF), which will be developed by a third-party corpor- ation (Beijing Guide Technology Co, Ltd) before recruit- ment begins. A third-party contract research ... See full document

... The randomised treatment will be recorded in the patient’s hospital notes and study notes and the surgeon will be ...Local study staff will oversee this ... See full document

... The trial is a randomized, multicenter, parallel, non-inferiority ...McMaster Osteoarthritis Index (WOMAC) score at baseline, the end of treatment, first follow-up, and second ...Lysholm knee score, ... See full document

... our protocol are as follows: (1) investi- gation responses on neuromuscular function use WBV ex- ercise and RT in individuals with KOA, which has not been described in this population; (2) the relatively long ... See full document

... The protocol meets the legal requirements involving research in humans, according to the Declaration of ...This protocol was ap- proved by the Ethics Committee of the Health Sciences Institute of the ... See full document

... manipulate the patient’s body surface by means of var- ious forms of tuina maneuvers such as pushing, knead- ing, rolling, wrenching, and flicking-plucking to relax and dredge the meridians and promote Qi flowing and ... See full document

... However, according to a recent systematic review [10] on the use of moxibustion for rheumatic conditions, only 4 RCTs [11-14] on KOA using moxibustion have been published, and it is difficult to provide conclusive ... See full document

... The outcome assessors are physical therapists of the MUMC + . The performance measures and strength assessments are part of their routine tasks and no special training prior to the study was needed. The purpose ... See full document