[PDF] Top 20 Nuclear thyroid hormone receptors
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Nuclear thyroid hormone receptors
... Isolation ofa cDNA encoding human Rev-ErbAa: transcription from the non-coding DNA strand of a thyroid hormone receptor gene results in a related protein which does not bind thyroid horm[r] ... See full document
7
Pedomorphosis revisited: thyroid hormone receptors are functional in Necturus maculosus
... To address these questions, we characterized the thyroid hormone receptors TRa and TRb in Necturus. Strikingly, we found that both receptors are active (i.e., able to bind to DNA, to ... See full document
9
The concise guide to pharmacology 2017/18: Overview
... protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and ...to Receptors ... See full document
16
Stimulation of hepatic mitochondrial alpha glycerophosphate dehydrogenase and malic enzyme by L triiodothyronine Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated
... plasma:nuclear relationship. As a first step, the analysis was confined to the limiting situation in which all nuclear sites were effectively saturated. The following additional information was required and ... See full document
12
Constant velocity pulling and unfolding of thyroid hormone receptor by steered molecular dynamics
... The initial structure of T3-liganded THR- isoform of nuclear receptor super family was taken from the protein data bank code 3GWS [12]. The THR- ligand binding domain (LBD) complex has the chain length of ... See full document
9
Synergism of thyroid hormone and high carbohydrate diet in the induction of lipogenic enzymes in the rat Mechanisms and implications
... We have investigated the relationship between the administration of triiodothyronine (T3) and a high carbohydrate (CHO) fat-free diet in the induction of lipogenic enzymes in two rat tissues, liver, and fat. Male ... See full document
10
Effect of High Normal Thyroid Stimulating Hormone Levels on Lipid Parameters in Non-diabetic Subjects
... that thyroid hormones and their function are low in target tissue which is believed to influence lipids by the same mechanism as seen in clinically hypothyroid state ...TSH receptors [TSHR] in ... See full document
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Thyroid Hormone Action IN VITRO CHARACTERIZATION OF SOLUBILIZED NUCLEAR RECEPTORS FROM RAT LIVER AND CULTURED GH1 CELLS
... We characterized further the kinetics of triiodothyronine (T3) and thyroxine (T4) binding and the biochemical properties of the nuclear receptor after extraction to a soluble form with 0.4 M KCl. In vitro binding ... See full document
14
Maternal hypothyroxinemia and the ontogeny of thyroid hormone nuclear receptors and cholinergic and monoaminergic neurotransmitter systems in developing rat brain
... Iodine deficiency is a primary cause of goitre and hypothyroidism. Nearly one third of the worlds population (1.5 billion people) are at risk from IDDs and 12% exhibit goitre of varying severity (290). The problem is ... See full document
249
Thyroid hormone and anti-apoptosis in tumor cells
... the nuclear membrane and fragmentation of ...activated. Thyroid hormone has anti-apoptotic actions on both the extrinsic and intrinsic ...The hormone also stabilizes the actin cytoskeleton via ... See full document
9
Thyroid stimulating hormone and insulin like growth factor 1 synergize to elevate 1,2 diacylglycerol in rat thyroid cells Stimulation of DNA synthesis via interaction between lipid and adenylyl cyclase signal transduction systems
... Thyrotropin thyroid-stimulating hormone, TSH and insulin-like growth factor- I IGF- 1 or high doses of insulin, which allows for interaction with receptors for IGF-1, are factors that st[r] ... See full document
6
Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the young
... Hepatocyte nuclear factor 4α is a member of the steroid/ thyroid hormone receptor super family and is expressed in the liver, kidney, small intestine and pancreatic islets ... See full document
6
Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis
... ‘thyroid hormone receptor like ...of thyroid like receptors in a BRCA1 mutant genetic ...of nuclear hormone receptors Table 2 VDR, RXR and PPAR γ immunopositivity in ... See full document
11
Models of buffering of dosage imbalances in protein complexes
... conformation when it is complexed with binding partners forming an oligomer [18]. This is epitomized by the interac- tions between domains of the cAMP response element binding protein (CREB-binding protein or CBP) and ... See full document
11
Clinical Profile of Hyperthyroidism at Stanley Hospital
... to receptors in thyrotrophs and prolactin synthesizing ...by thyroid hormone by slow process whereas estrogen increases TRH response by increasing sensitivity in ... See full document
111
microRNA and thyroid hormone signaling in cardiac and skeletal muscle
... proliferators-activated receptors β/δ and PPARα on energy metabolism and skeletal muscle fiber specific- ity [63, ...hypo- thyroid state induces both Myh7/miR-208b and Myh7b/ miR-499 expression in skeletal ... See full document
8
Interaction of human beta 1 thyroid hormone receptor and its mutants with DNA and retinoid X receptor beta T3 response element dependent dominant negative potency
... beta thyroid hormone receptor (h-TR beta) gene are associated with the syndrome of generalized resistance to thyroid ...mutant receptors showed an increased tendency to form homodimers on a ... See full document
9
Congenital Hypothyroidism and Nonimmune Hydrops Fetalis: Associated?
... that thyroid hormone may play a role in the regulation of adrenergic receptors in the lymphatic system and lungs, thus modulating both the lymphatic flow rate and lung liquid clearance and ... See full document
5
v-erbA acts on retinoic acid receptors in immature avian erythroid cells.
... Modulation of normal erythroid differentiation by the endogenous thyroid hormone and retinoic acid receptors: a possible target for v-erb A oncogene action.. The v-erb A oncogene causes [r] ... See full document
8
Growth and Development in a Child With Resistance to Thyroid Hormone and Ectopic Thyroid Gland
... and thyroid dysgenesis would be expected to occur by chance in just 1:140 000 ...the thyroid hormone receptor may also have a role in thyroid organogene- ...sis. Thyroid hormone ... See full document
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