[PDF] Top 20 P53, a potential target for tumor-directed cells
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P53, a potential target for tumor-directed cells
... We identified the p53 peptides with the highest affinity to the HLA-A*0201 molecule using two assays: the peptide binding assay and the peptide competition assay.. The results of both te[r] ... See full document
8
Inhibiting bladder tumor growth with a cell penetrating R11 peptide derived from the p53 C-terminus
... functional p53 protein in cancer cells will be ...by p53 reactivation using a peptide derived from the p53 C-terminus ...reactivating p53 in controlling bladder cancer development is ... See full document
10
Tumor dormancy: potential therapeutic target in tumor recurrence and metastasis prevention
... disseminated tumor cells (DTCs) remain oc- cult, asymptomatic, and undetectable over a prolonged period of ...of tumor development but also when remnant tumor cells escape ...treatment. ... See full document
8
The Effect of Wild Type P53 Gene Transfer on Growth Properties and Tumorigenicity of PANC-1 Tumor Cell Line
... human p53 cDNA, coupled to the neo gene under CMV promoter ...resistant cells were recovered 3-4 weeks post- transfection and single-cell clones were then isolated and ...of p53 protein by ... See full document
6
Peripheral medulloepithelioma: a rare tumor with a potential target therapy
... columnar cells, vesicular nuclei, and high nuclear-cytoplasmic ...neoplastic cells showed a diffuse positivity for CD56 and WT1 (cyto- plasmic) and a variable positivity for NSE, Synaptophisin, S100 protein ... See full document
6
CSE1L, a Novel Microvesicle Membrane Protein, Mediates Ras-Triggered Microvesicle Generation and Metastasis of Tumor Cells
... important target for targeted cancer therapy ...a potential marker for cancer diagnosis as well as for monitoring the response of targeted therapy in HER/ ErbB-positive ... See full document
12
Heterogeneous PSMA expression on circulating tumor cells - a potential basis for stratification and monitoring of PSMA- directed therapies in prostate cancer
... circulating tumor cells (CTCs) obtained from the peripheral blood of PC patients might provide an alternative to tissue biopsies called “liquid ...line cells (PC3, LaPC4, 22Rv1, and LNCaP) by Western ... See full document
12
Bone Tumor Environment as a Potential Therapeutic Target in Ewing Sarcoma
... bone tumor micro- environment, can both inhibit and facilitate tumor growth and metastatic dissemination, better modelization of the tumor bone niche is needed to characterize tumor ... See full document
11
Engineering switchable and programmable universal CARs for CAR T therapy
... T cells can only target one antigen ...the target antigen can be switched or re-directed more readily without the requirement of re-engineering the CAR T ...T cells and the ... See full document
9
Index Catalog // Carolina Digital Repository
... in p53- deficient mice, which are highly tumor prone, increased their tumor-free survival (Ozturk et ...the p53-null and Cry-deficient tumor cells compared with those in ... See full document
70
ERβ decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function
... and target genes that may account for the decreased invasiveness of ERβ1-expressing TNBC cells [26, ...mutant p53 signaling since p53 is frequently mutated in TNBC and mutant p53 ... See full document
13
Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway
... adapting tumor cells to ER stress and the secretion of growth factors [6, 10, ...of p53 expressed high levels of ...these cells in the absence of stress. Therefore, our data suggest that ... See full document
12
Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells
... the tumor cells within a given cancer, while leaving healthy tissue unaffected, is still far from a reality ...in tumor cells and which appears to overcome this limitation ...apparently ... See full document
9
Circulating tumor cells as a potential biomarker for postoperative clinical outcome in HBV-related hepatocellular carcinoma
... the tumor and surrounding tissue were fixed in formaldehyde, dehydrated in graded ethanols, embed- ded in paraffin, and cut into 4-µm slices for ...positive cells in three random high-power fields ( × 400). ... See full document
9
Multi stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation
... erythroid cells fail to mature beyond the proeryth- roblast stage and die by apoptosis ...erythroleukemic cells is supported by the reversal of tumorigenicity and the re-initiation of a differentiation ... See full document
11
Glioblastoma without Remarkable Contrast Enhancement on Magnetic Resonance Imaging
... the tumor tissue in case 4. Tumor cells were pleo- morphic with nuclear atypia, and had some cytoplasm ((a), hematoxylin and eosin (HE) staining, original magnifica- tion ...the tumor ... See full document
7
Peptide Interactions Stabilize and Restructure Human Papillomavirus Type 16 E6 To Interact with p53
... of p53. E6AP-null 8B9 cells are murine em- bryonic kidney cells from E6AP-null mice transformed by adeno- virus E1a and mutation-activated Ras; in contrast to results obtained previously with these ... See full document
6
<p>Staphyloxanthin: a potential target for antivirulence therapy</p>
... The Hfq (a host factor for RNA phage Q β ) protein was considered to be an RNA chaperone, which was a multifunctional regulator in bacteria. 56 Deletion of hfq gene in S. aureus 8325-4 (a SigB de fi ciency, non- ... See full document
10
SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B
... U87 cells were cultured in MEM medium with 10% FBS at 37 °C and 5% CO2 ...U251 cells (U251-SIX3) and GFP stably expressing U251 cells (U251-CON) were constructed with lenti-virus and cultured in the ... See full document
16
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
... many p53 mutants are associated with a conform- ational change that hinders its DNA binding and trans- activation capacity, it is rationalized that small molecules that revert the mutant p53 to its ... See full document
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