[PDF] Top 20 Pathogenesis of Neuropsychiatric Syndromes of Systemic Lupus Erythematosus

... The pathogenesis of NPSLE is multifactorial and can involve various inflammatory cytokines, autoantibodies such as anti-neuronal antibodies, anti-ribosomal P antibodies (anti-P), anti-NR2 glutamate receptor ... See full document

... of lupus patients with nephritis ...[57]. Lupus mice defi cient in TNF receptor 1 and 2 develop accelerated lupus via a Th 17-associated pathway ...in lupus-prone mice [59]. Eff ective peptide ... See full document

... the lupus background strain (MRL/ MpJ) mice, which do not have the recessive lpr gene mutation that the MRL/lpr mice have, but that still develop a late-onset, mild arthri- tis and glomerulonephritis ... See full document

... of lupus patients with nephritis and controls in Figure ...Twelve lupus cases of varying disease activity and healthy control individuals were included in the ... See full document

... Although not fully understood, TLRs have been implicated in the pathogenesis of various autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and [r] ... See full document

... the pathogenesis of several autoimmune disorders such as rheumatoid arthritis, crohn’s disease and psoriasis (Ps), and specific IL blockade has been utilized successfully to treat patients with these diseases ... See full document

... First, lupus is a complex disease and many different elements con- tribute to its ...the pathogenesis of SLE, research thus far has concentrated on a small group of cytokines, notably tumour necrosis factor ... See full document

... The prevalence of a positive LBT in lesional, NLSE and NLSP skin in our local SLE patients is similar to that reported in most other series. We therefore agree that for the diagnosis of SLE, the best site for the LBT ... See full document

... of systemic disease. Neuropsychiatric signs can be the initial presentation of patients ultimately di- agnosed with SLE and are similarly among the earliest abnormalities identified in young MRL/lpr mice ... See full document

... the pathogenesis of systemic lupus erythematosus (SLE), the usage of V k and J k gene elements from individ- ual peripheral CD19 1 B cells obtained from a patient with untreated SLE was ... See full document

... Oxidative stress has been implicated in the inflam- matory process of Systemic Lupus Erythematosus (SLE), particularly by the formation of anti-DNA autoantibodies, which can lead to DNA damage. The ... See full document

... the pathogenesis of NPSLE and its probable diag- nostic faculties, ADC histogram analysis might also be a useful tool for monitoring the progression of disease in an individual ... See full document

... the SLE Activity Index (SLEDAI) [11]. Treatment with corticosteroids or immunosuppressive drugs was insti- tuted as indicated following completion of these evalua- tions. One non-NPSLE patient at admission, who later ... See full document

... Lifetime prevalence of neuropsychiatric symptoms in SLE has been estimated to range from 80% to 91%. 1,2 Neurologic manifestations include cognitive dysfunction, stroke, seizures, headache, neuropathy, and ... See full document

... ANA is a good screening test for SLE because 95% of cases show a high titre (1:80 or more) of this autoantibody. A negative test result makes the diagnosis highly improbable. ANA may be positive in other rheumatic ... See full document

... The findings from the current study indicate that there were more extensive local and global reorganizations in the structural brain network of patients with NPSLE than in those with SLE and that these changes are the ... See full document

... In the present study, significant cognitive impairment was noted in patients with or without neuropsychiatric manifestations than in the control group. This impair- ment was more apparent in long-term memory, ... See full document

... Neuropsychiatric systemic lupus erythematosus (NPSLE) is a complex neurological disorder characterized by neu- ropsychological dysfunction ...[2,3]. Neuropsychiatric manifesta- tions, ... See full document

... syndrome, systemic lupus erythematosus, neuromyelitis optica, and lymphoma, and paraneoplastic syndromes, such as anti-Hu and anti-Ma2 antibody-associated encephalitides, can also cause a ... See full document

... Introduction: Acquired immunodeficiency syndrome (AIDS) linked to HIV infection is accompanied by auto-immune phenomena. Autoimmune diseas- es can develop in people living with HIV, most in a context of good immu- ... See full document