[PDF] Top 20 Performance evaluation of the Xpert MTB/RIF assay according to its clinical application

... desired clinical application of the Xpert ...the clinical symptoms (cough, fever, night sweats, or weight loss) and radiologic findings compatible with tuberculosis, in either a chest X-ray or ... See full document

... (ii) Substudy laboratory testing methods. All laboratory assessments completed as part of the parent study were described previously (10). In this substudy, only samples tested at the Uganda laboratory site were ... See full document

... the Xpert assay was applied to diagnose musculoskeletal ...model according to ...of Xpert for the diagnosis of musculoskeletal TB. Xpert was highly sensitive ...of Xpert for ... See full document

... Xpert MTB/RIF is a TB-specific automated, car- tridge-based nucleic amplification assay with fully integrated and automated sample prepa- ration, amplification and detection of Mtb, as ... See full document

... on clinical symptoms including, history of fever, cough, weight loss and abdominal ...assessed according to the diagnostic algo- rithm utilized by the Pakistan Pediatric Association which is based on the ... See full document

... TB Xpert performed well on gastric aspirates, with a similar relative sensitivity to liquid culture as for sputum samples ...and Xpert on sputum for clinically con- firmed cases is likely due to confounding ... See full document

... randomised clinical drug trial REMoxTB at two of the 47 clinical trial sites in Cape Town, South Africa, and Mbeya, Tanzania, between January, 2008, and April, ...treatment, according to current ... See full document

... INNO-LiPA RIF TB (Innogenetics, Ghent, Belgium) and the Genotype MTBDRplus (Hain Life-Sci- ence, Nehren, Germany) (here referred as to ...and Xpert MTB/RIF assays have shown good ... See full document

... by Xpert assay were compared with the available demographic and clinical data for 205 RR-TB patients (Table ...female. According to treatment history, most of the patients (202/205, ... See full document

... the Xpert MTB/RIF ...the Xpert MTB/RIF Ultra assay in our cohort, and this test may have higher sensitivity than current diagnostic tests ...diagnostic performance ... See full document

... [16]. Performance of Xpert MTB/RIF in tuberculosis spondylitis has been reported in very few ...disease, Xpert MTB/RIF had a sensitivity of ...using Xpert ... See full document

... the Xpert MTB/RIF test in 2011, the World Health Organisation (WHO) recom- mended the use of the test as an initial diagnostic tool among children with suspected HIV associated TB or Multi-Drug ... See full document

... Biosafety. To test the biosafety of the processing protocol for the IS6110 LDT, processed smear-positive patient specimens (n ⫽ 10) and the M. tuberculosis control strain were cultured prior to the placement of the ... See full document

... of RIF resistance in mixed isolate ...both RIF-susceptible and RIF- resistant populations of ...the assay to detect the RIF-resistant fraction of a mixed ...the Xpert ... See full document

... on clinical samples. The performance of Ultra on clinical sputum samples was done in a limited retrospective accuracy study at the National Reference Laboratories in Belarus and Georgia and at the ... See full document

... Routine diagnostic standard. In this setting, clinical specimens are routinely submitted for smear, culture, and GenoType MTBDRplus (v1.0) LPA (Hain Life Sciences, Germany) sensitivities. All sputum pro- cessing ... See full document

... managed according to South African TB management guidelines ...ray, clinical diagnosis, lymph node aspirate, ...positive Xpert MTB/RIF, RT-MTB, or Ultra result and lack of growth ... See full document

... The performance of mycobacterial culture (culture), the Xpert MTB/RIF assay (Xpert), the ...T-SPOT.TB assay (T-SPOT), the adenosine deaminase assay (ADA), and cf-TB ... See full document

... tems) according to the manufacturer’s instructions and resuspended in 700 ␮l of phosphate-buffered saline (PBS), pH ...OADC according to the manufacturer’s ...TB-Neo assay (Tauns, Shizuoka, Japan) ... See full document

... the Xpert MTB/RIF is an on-demand assay described as a simple method that can be performed by personnel with minimal training and can provide results within 2 h (1, 3, ...the Xpert ... See full document