[PDF] Top 20 Phosphorylation of hepatitis B virus precore and core proteins.
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Phosphorylation of hepatitis B virus precore and core proteins.
... To investigate whether the phosphorylation of core and precore proteins requires other HBV gene products, we fused the putative phosphorylation sites the carboxy terminus of the precore-[r] ... See full document
5
Immune Tolerance Split between Hepatitis B Virus Precore and Core Proteins
... the hepatitis B virus (HBV) exists in two structural ...titis core antigen (HBcAg), is an intracellular 21-kDa protein that self-assembles into particles that encapsidate the viral genome and ... See full document
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The arginine-rich domain of hepatitis B virus precore and core proteins contains a signal for nuclear transport.
... In order to investigate whether this sequence contains an unusual nuclear localization signal, a protein named lOG was created by fusing the proximal precore sequence to the amino termin[r] ... See full document
7
Phosphorylation of vaccinia virus core proteins during transcription in vitro.
... The initiation factor VETF i has been purified as a dimer composed of 77and 82-kDa polypeptides, ii allows the core RNA polymerase to initiate correctly on double-stranded templates, and[r] ... See full document
7
Hepatitis B Virus DNA Replication Is Coordinated by Core Protein Serine Phosphorylation and HBx Expression
... mutant core proteins were capable of encapsidating pgRNA, HepG2 cells were transfected with the different HBV replicons, capsids were purified by immunoprecipitation using a polyclonal anti- serum to the ... See full document
11
Phosphorylation of the Core Protein of Hepatitis B Virus by a 46-Kilodalton Serine Kinase
... the core particle (nucleocapsid) of human hepatitis B ...virus. Core particles and core proteins are involved in a number of important functions in the replication cycle ... See full document
8
Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation.
... GST-HCV core fusion proteins by PKA and ...HCV core pro- tein has three putative PKA recognition sites (amino acid residues 15, 53, and 116) and five PKC recognition sites (amino acid residues 11, ... See full document
12
Clinical Significance of Hepatitis B Virus (HBV) Genotypes and Precore and Core Promoter Mutations Affecting HBV e Antigen Expression in Taiwan
... independent factors for advanced liver disease. In this study, the frequency of the T1762 and A1764 mutant increased with advanced liver disease in both genotype B- and genotype C- infected patients. These ... See full document
7
Mechanism of Suppression of Hepatitis B Virus Precore RNA Transcription by a Frequent Double Mutation
... of precore and core RNAs, M5 expressed a reduced level of these two RNAs ...of precore and core RNAs by suppressing the two HBV enhancers, because the transcrip- tion of the S gene, which is ... See full document
6
Enrichment of a Precore-Minus Mutant of Duck Hepatitis B Virus in Experimental Mixed Infections
... wild-type virus was correlated with elevated levels of anticore antibody that increased throughout the follow-up ...Anti- core antibody titers in the group of birds showing no selection against wild-type ... See full document
7
In Vitro Study of the Effects of Precore and Lamivudine-Resistant Mutations on Hepatitis B Virus Replication
... malian virus promoter, such as green fluorescent protein driven by cytomegalovirus, the expression of the gene product is transient, peaking at 48 to 72 h posttransduction and becom- ing undetectable by 5 to 6 ... See full document
9
The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.
... pre- core-mediated dominant negative effect occurred without re- ducing the steady-state level of HBV RNA, suggesting that precore gene products do not interfere with viral transcription in the nucleus ... See full document
6
Hepatitis B Virus Core Related Antigens as Markers for Monitoring Chronic Hepatitis B Infection
... related proteins would continue to be produced for a certain period of time in spite of the achievement of adequate sup- pression of the viral DNA ...truncated precore protein, which is also detected by the ... See full document
6
Original Article Association of hepatitis B virus basal core promoter T1762/A1764 and precore A1896 mutations with serum hepatitis B virus DNA load, hepatitis B e antigen status, serum α-fetoprotein and hepatitis B virus-related liver disease progression
... basal core promoter (BCP) T1762/A1764 dual mutation and precore (PC) A1896 mutation of HBV are associated with an increased risk of HBV- related liver disease ...the virus throughout the liver, and ... See full document
13
Development of a Molecular Beacon Assay To Detect the G1896A Precore Mutation in Hepatitis B Virus Infected Individuals
... The rapidity and high capacity of this assay enable detection of PC mutants for up to 96 samples within 3 h (27). The molecular-beacon assay is inexpensive, rapid, specific, and sim- ple compared to other assays used to ... See full document
5
Expression of the hepatitis B virus core gene in vitro and in vivo.
... Extracts of three HBV-infected human livers lanes 1 to 3, in vitro-synthesized core proteins initiated at ATGs 1 lane P and 2 lane C of the C gene, and immunoprecipitated precore and cor[r] ... See full document
5
Application of a Novel, Rapid, and Sensitive Oligonucleotide Ligation Assay for Detection of Cancer Predicting Mutations in the Precore and Basal Core Promoter of Hepatitis B Virus
... (6.5%) BCP IND samples compared to no pre-C IND samples in the DNA sequencing assay and 6.5% (5/76) BCP IND sam- ples compared to 2.6% (2/76) pre-C IND samples in the OLA. Three OLA IND samples (samples 1, 2, and 10), ... See full document
8
Cell-Free Hepatitis B Virus Capsid Assembly Dependent on the Core Protein C-Terminal Domain and Regulated by Phosphorylation
... Analysis of nonspecific RNA packaging by WT and mutant HBV capsids. The results shown in Fig. 4 and 5 and described above suggested that the capsids assembled in RRL might package RNA in a manner dependent on the state ... See full document
15
Hepatitis B Precore Protein: Pathogenic Potential and Therapeutic Promise
... Hepatitis B virus (HBV), a small and economically packaged double-stranded DNA virus, represents an enormous global health care ...Chronic hepatitis B (CHB) results in the ... See full document
11
Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide.
... Since COS-7 cells transfected with pECE-PC did not synthesize detectable amounts of P21c, we cotransfected plasmids expressing core and precore proteins pECE-C and pECE-PC, respectively [r] ... See full document
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