[PDF] Top 20 Potential clinical application of lncRNAs in non-small cell lung cancer

... these lncRNAs are not mature enough, accumulating evidence suggests that lncRNAs do have significant functions in epigenetic regulation, promote proliferation and cellular growth, and result in uncontrolled ... See full document

... Background: Non-small cell lung cancer (NSCLC) is the most frequent cause of cancer deaths ...few potential predictive biomarkers for prognosis of NSCLC patients were ...a ... See full document

... germ cell development, stem cell self- renewal, and retrotransposon ...colorectal cancer [83], gli- omas [84] and esophageal squamous cell carcinomas ...gastric cancer tissues was ... See full document

... breast cancer model, persistent PI3K/AKT/ mTOR and MEK/ERK signaling is maintained, and dual inhibition of these pathways has been shown to be an effec- tive treatment ... See full document

... In particular, afatinib should be used in patients with classical mutations in the EGFR gene (exon 19 deletions and exon 21 point mutations) and could be considered in the presence of G719X and L861Q mutations. Patients ... See full document

... renal cell cancer thus found that a low BSA was associated with a higher incidence of DLTs, which were retrospectively defined as any toxicity leading to a dose reduction or treatment discontinuation and ... See full document

... relatively small, and results were needed to be further ...randomized clinical trials, and including molecular mechanism studies are needed in the ... See full document

... multiple lung cancers, both ipsilaterally (n = 27) and contralaterally (n = 28), the 5-year survival rate was not significantly different between the two groups, reported to be 27 and 43% ...that Clinical ... See full document

... of the clinical impact of COPD would not be significantly influenced by the paucity of cases of severe COPD. Second, we did not identify other comorbidities. Cardiovascular disease, which frequently accompanies ... See full document

... prognostic potential of circulating exosomal miRNAs in several cancers, including lung ...that lung cancer histotypes could be distinguished by a 4-miRNA panel with high sensitivity and ... See full document

... with lung adenocarcinoma not selected for EGFR mutational status, even if the study popu- lation had clinical characteristics frequently associated with the presence of EGFR ... See full document

... a potential mechanism of resistance to immunotherapy adopted by ...important clinical implications because the treatments options for NSCLC and SCLC are ... See full document

... of Lung Cancer TNM staging ...and clinical data of all ...by Clinical Research Ethics Committee of the Korea University Anam Hospital (approval number: ... See full document

... IIIB non-small cell lung cancer who had no clinical symptoms of superior vena cava syndrome at the time of ...a potential etiology for the precipitation of the superior ... See full document

... On the basis of promising preclinical activity and an acceptable safety profile, bavituximab is currently under investigation in combination with chemotherapy for advanced NSCLC in several trials. The second-line setting ... See full document

... advanced non-small-cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutations with and without T790M mutation: the Spanish Lung Cancer ... See full document

... with lung cancer had already been recruited via the ChemoRes EU Framework 6 integrated project ...inclusion, small cell lung cancer (SCLC) had to be histologically or ... See full document

... exact clinical significance of CXCL5 in lung cancer has not been well ...in non-small cell lung cancer (NSCLC) compared with that in healthy ...various lung ... See full document

... by cancer cells to evade the host immune response are valuable targets for ...them. Cancer cells, however, can also change their microenvironment to an immunosuppressive state via cytokine expression (TGF- ... See full document

... ambulatory non-invasive ...of clinical applications ...of cancer patients [75] in comparison with CTCs, that could lead exosomes to be more exploitable for isolation and analysis ... See full document