[PDF] Top 20 Prognostic factors and risk stratification in patients with castration-resistant prostate cancer receiving docetaxel-based chemotherapy

... many patients in our cohort received ...to docetaxel based chemotherapy in Europe and United ...with docetaxel based ...Japanese patients [30]. Finally, most ... See full document

... into prognostic groups according to different factors known to affect prostate cancer ...Pretreatment risk stratification also plays an important role in the selection and ... See full document

... Armstrong risk classification (ARC), which classifies CRPC patients into 3 groups ac- cording to 4 risk factors, including visceral metastases, bone scan progression, significant pain, and ... See full document

... Prognostic factors correlate with outcome independent of treatment ...Predictive factors inform on the probability of response to a treatment and therefore are more useful in helping clinicians ... See full document

... a prognostic index including six risk factors (RFs) (unfavourable ECOG performance status [PS], presence of liver metastases, short response to luteinizing hormone- releasing hormone [LHRH] ... See full document

... of prostate cancer are vital for informing trial interpretations, as they provide key insights into pa- tients’ symptoms and treatment response ...with prostate cancer face issues that differ ... See full document

... six risk factors (RFs) linked to poor survival: Eastern Cooperative Oncology Group performance status (ECOG PS) ≥2, liver metastases, time from initiation of androgen- deprivation therapy (ADT) to ... See full document

... in patients with mCRPC who received first-line DTX or post-docetaxel ...of docetaxel-based therapy and ...after chemotherapy. PSA cannot Table 6. Associated Baseline Factors of ... See full document

... of patients enrolled in a prospective study. The small number of patients included in this study could limit its statisti- cal power to detect smaller ...a prognostic factor, but could not be ... See full document

... with chemotherapy ver- sus placebo and was strongly associated with PSA declines (Prentice criterion ...significant prognostic informa- tion for mCRPC patients, they are not always a surrogate for ... See full document

... of docetaxel re-treatment in docetaxel- pretreated CRPC patients, the authors showed that docetaxel re-treatment preserves antitumor activity and is well tolerated in a selected population of ... See full document

... Clinical Cancer Research) encompass- ing a wide range of disease ...and prognostic factors used for stratification at ran- ...higher risk of death from coexisting conditions and a rela- ... See full document

... the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) based on a 62.. demonstrated survival benefit and a favorable tolerability profile in both t[r] ... See full document

... suppressor cells (MDSCs) in metastatic castration-resistant prostate cancer (CRPC) patients 20. (PTS)[r] ... See full document

... Surprisingly, the decline in long LINE1 in our case study coincided with elevated allele frequency of mutant AR. These results suggest that chemotherapy affected cfDNA derived from the tumor differently than from ... See full document

... of patients Ac-225-PSMA-617 will ...specific prostate cancer subtypes, such as those with DNA repair defects, are more sensitive to selective tumor cell kill by alpha-particle emitting ... See full document

... 25 patients were treated with ...25 patients received all six injec- tions of ...in patients with VAS ,4 vs ...a prognostic factor of survival (HR = ... See full document

... databases. Patients treated for other cancer types, including small cell carcinoma of the prostate and prostate cancers with neuroendocrine features, were ... See full document

... score performed better than cell count-based clinical pa- rameters in both validation datasets (Tables 3 and 4), suggesting that cell component change was only one fac- tor contributing to the patients ’ ... See full document

... Before the emergency operation, septic shock was recog- nized, and after the operation, in addition, she developed disseminated intravascular coagulation and oliguria due to acute renal failure. We used continuous venous ... See full document