[PDF] Top 20 Progress in mesenchymal stem cell–based therapy for acute liver failure

... improve liver function, inhibit cell apoptosis, and prolong the survival time of pigs with ALF ...reduce liver inflammation, decrease liver degeneration and necrosis, and promote liver ... See full document

... MSCs therapy minimized kidney injury following IRI by suppressing oxidative stress and the inflammatory ...necrosis. Based on the ability of cyclosporine to reduce the generation of reactive oxygen species ... See full document

... of cell therapies (haematopoietic, mesenchymal and unsorted cell types) of autologous or allogeneic origin and/or the use of granulocyte colony-stimulating factor in patients with CLD including ACLF ... See full document

... heart failure is one of the major causes of cardiovascular mortality [1, ...7]. Stem cell based therapy has generated significant interest and to date (today) preclinical research has ... See full document

... Liver failure is a severe liver damage caused by a variety of reasons, resulting in serious disorders or decompensation of its synthesis, detoxification, excretion, biotransformation, and other ... See full document

... include cell replacement, growth factor secretion, and biobridge formation ...the acute phase or ‘neuroregenerative’ for the subacute and chronic stages of stroke ...The acute treatment in stroke is ... See full document

... hematopoietic stem cells through the secretion of IL-1a, IL-1b, IL-6, IL-7, IL-8, IL- 11, IL-14, IL-15, leukemia inhibitory factor, stem cell factor, thrombopoietin, fetal liver tyrosine ... See full document

... of stem cell therapy in patients with ACLF ...that stem cell therapy is safe and has beneficial effects on ...of stem cell therapy [5, ...of stem ... See full document

... of acute liver ...marrow mesenchymal stem cells, could undergo long-term culture in vitro without loss of ...fat-derived stem cells were isolated and cocultured with rat ...an ... See full document

... Mesenchymal stem cells (MSC) are the most available and important adult stem ...Fluorescence-activated cell sorting showed gene expression of CD90 and CD29 but not CD45 in MCS from ...the ... See full document

... and acute rejec- tion, and causes adverse effects on graft outcome ...of acute re- jection, which also exerts an adverse effect on graft sur- ...suppressing acute rejection may be a promising way to ... See full document

... the failure to demonstrate the efficacy of rituximab in renal and extra-renal manifestations of SLE ...B cell- activating factor of the tumor necrosis factor family (BAFF), belimumab anti-Blys, was the ... See full document

... The effectiveness of genetically modified auto-MSCs has been reported in different disease models [50–52]. Similarly, the protective effect of allo-MSCs was im- proved by gene modification. de la Garza-Rodea et al. [53] ... See full document

... pulp, liver, lung, thymus, synovium, and adipose tissues, offering various choices for their application ...lular Therapy (ISCT) suggests that researchers use mesen- chymal stromal cells (MSCs) as the ... See full document

... whole liver of the rat, with one layer of ...determined based on previous literature examples [15, ...stromal cell-derived factor 1 (SDF-1) and tumor necrosis factor α (TNF-α) was ... See full document

... Liver cirrhosis mainly results from excessive depos- ition of newly generated extracellular matrix (ECM) in response to injury, which involves the activation of hep- atic stellate cells (HSCs) [11]. HSCs are a ... See full document

... the liver functional indices of the ASC-treated group were significantly improved (Figure ...to liver cell prolifera- tion by Ki-67 ...The liver section of the PBS-treated group was ... See full document

... the liver in animals injected with the hcMSC fraction was characterized by the most favorable appearance: congestion of the lobules was usually not observed (Figure 3E – ...outer cell membranes had distinct ... See full document

... to cell type, delivery route, administration frequency, and type of trial did not provide a clear ...of liver disease might also be sources of heterogeneity among the included ... See full document

... showed that MSCs were safe in treating IS as well. No serious adverse events have been reported during MSC therapy. Most common side effects, including fever and headache, usually resolved naturally. However, ... See full document