[PDF] Top 20 Progress in stem cell-derived technologies for hepatocellular carcinoma

... In this model, DENA is administered first as an initiator, and after two weeks the animals were fed with 2-AAF to inhibit the proliferation of no initiated hepatocytes. Two-thirds partial hepatectomy was then performed ... See full document

... Abstract: Hepatocellular carcinoma (HCC) carries a dismal prognosis, with advanced disease being resistant to both radiotherapy and conventional cytotoxic drugs, whilst anti- angiogenic drugs are marginally ... See full document

... squamous cell carcinoma [15], glioblastoma [16], head and neck squamous cell carcinoma [17], ovari- an cancer [18, 19], cholangiocarcinoma [20], lung cancer [21, 22], breast cancer [23, 24], ... See full document

... cancer stem-like cells (CSC), which exhibit self-renewing capacities and are responsi- ble for tumor maintenance and metastasis [3] and pos- sibly for resistance towards chemotherapy and radiation therapy ...with ... See full document

... Time course MRI was adopted to confirm the hom- ing of MSCs to the injured liver, and to document their therapeutic effects by correlating the radiologic findings to the hepatic pathology. Figure 5 follows the labeled ... See full document

... non-small cell lung carcinoma (NSCLC) and influences the mitochondrial respiration and aerobic gly- colysis affecting the cell oxygen consumption rate (OCR) and extracellular acidification rate ... See full document

... miRNAs are conserved evolutionary single long non-coding small RNAs about 22 nt long, which regulate the expression of target genes by binding to the mRNA untranslated region (UTR) sequence in complete or incomplete ... See full document

... Hepatocellular carcinoma is a major health problem with increasing ...surgical technologies, radical resection of tumor lesions and liver transplantation have become the standard curative therapies ... See full document

... and hepatocellular carcinoma, as well as the most common indication for liver transplantation in many countries with an estimated 180m people infected worldwide and up to 80% progress to ... See full document

... the cell viability and success rate for cancer ...cancer stem cells (CSC) prior to implantation into mice was shown to improve engraftment rates ...and cell line establishment. For in vitro ... See full document

... human stem cell and three-dimensional (3D) culture technologies made it possible to generate novel 3D neural cell culture models that recapitulate AD pathologies including robust A β ... See full document

... HCC derived cancer stem-like cell With the identification of the spheroid formation derived from self-assembly of cancer stem-like cells, the properties of these cells were analyzed ... See full document

... a cell surface molecule, has been used as a CSC marker [14]; aldehyde dehydrogenase-1 (ALDH-1) is highly expressed in various tumorigenic cells and has shown great potential as a CSC marker for the isolation and ... See full document

... Hepatocellular carcinoma (HCC) is one of the most common cancers that typically has poor prog- nosis. It is the third leading cause of cancer deaths worldwide, especially in Asia (1-3). Traditional the- ... See full document

... resistance of LCSCs to chemotherapy and more robust survival [37]. OCT4 plays a pivotal role in maintaining the multidirectional differentiation and self-renewal properties of embryonic stem cells [27–29]. OCT4 is ... See full document

... As has been shown, the etiology of HCC is very complex and involves a large number of genetic and epigenetic alterations as well as the consequent disruption of numerous signaling pathways, which can be candidate ... See full document

... inhibited cell stemness, proliferation, and metastasis in ...HCC cell lines such as proliferation and metastasis, however, the exact molecular mechanism remains unclear since the authors only reported the ... See full document

... The methods and protocols of this work were all approved by the Ethics Committee of Chinese PLA General Hospital and this study was conducted in accordance with the Declaration of Helsinki. All patients included in this ... See full document

... hematopoietic stem cell trans- plantation in preclinical [34] and clinical studies ...first stem cell drug, has been approved for the ... See full document

... The patient took Chinese herbal medicine (CHM) orally after the surgery in December 3, 2009, and received regular follow-up until June 29, 2012. No side effects were noted. The treatment principle of CHM is to invigorate ... See full document