[PDF] Top 20 Proprotein convertases in high-density lipoprotein metabolism
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Proprotein convertases in high-density lipoprotein metabolism
... Normal regulation of insulin, glucose, hormones, and lipids is important for HDL homeostasis, which involves synthesis, action, and elimination of HDL lipoproteins [35,36]. Mutations in PCSK1 and PCSK5 may cause ab- ... See full document
8
Role of lipoprotein lipase in the regulation of high density lipoprotein apolipoprotein metabolism Studies in normal and lipoprotein lipase inhibited monkeys
... of high density lipoprotein (HDL) associated with hypertriglyceridemia were studied in an animal ...inhibit lipoprotein lipase (LPL), the rate-limiting enzyme for triglyceride ... See full document
12
Anti-PCSK9 antibodies for the treatment of heterozygous familial hypercholesterolemia: patient selection and perspectives
... by high low-density lipoprotein cholesterol levels from birth, which exposes the arteries to high levels of atherogenic lipoproteins lifelong and results in a significantly increased risk of ... See full document
9
Original Article Association of the PCSK7 rs2277287 polymorphismand serum lipid levels in the Jing and Han populations
... the proprotein convertase subtilisin/ kexin type 7 gene (PCSK7) has been associated with serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol ... See full document
15
The Evolution of lipid Metabolism in Iraqi Children with Nephrotic Syndrome
... (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were determined in a study of 42 Iraqi children, half of which ... See full document
8
The Regulation of Proprotein Convertase Subtilisin/ Kexin Type 9 and Its Liver Involvement
... Introduction: Anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies have been very effective to lower low-density lipoprotein (LDL)-cholesterol. They attracted the attention on PCSK9 ... See full document
12
Profile of evolocumab and its potential in the treatment of hyperlipidemia
... low-density lipoprotein (LDL) cholesterol goals, especially in high-risk ...inhibiting proprotein convertase subtilisin/kexin type 9 that binds to the liver LDL receptor and prevents it from ... See full document
10
Central Role of High Density Lipoprotein in Plasma Free Cholesterol Metabolism
... vivo metabolism in man of free (unesterified) cholesterol in the major lipoprotein ...acid, high density lipoprotein (HDL)-free [ 14 C] cholesterol, low density ... See full document
13
High Density Lipoprotein Metabolism in Man
... I-high density lipoprotein (HDL) was examined in a total of 14 studies in eight normal volunteers in an attempt to determine the metabolic relationship between apolipoproteins A-I (apoA-I) and A-II ... See full document
14
Monoclonal antibody inhibition of cholesteryl ester transfer protein activity in the rabbit Effects on lipoprotein composition and high density lipoprotein cholesteryl ester metabolism
... Cholesteryl ester transfer protein (CETP) promotes in vitro transfer of cholesteryl ester (CE) and triglyceride (TG) between lipoproteins. We studied the function of CETP in vivo in rabbit lipoprotein ... See full document
10
Evaluation of lipid profile and apolipoproteins in cord blood fromrural and urban population of Udaipur region
... lipid metabolism may be detected very early in life as in the cord blood ...lipid metabolism may be the result of the influence of genetic or environmental factor, However evaluation showed no statistical ... See full document
5
GENETIC RESEARCHES AMONG MALAYSIAN FAMILIAL HYPERCHOLESTEROLAEMIC POPULATION
... Hean Lye et al further hypothesised that SNPs could exert their effects separately and that multiple SNPs could act synergistically to alter the susceptibility to the disease. They investigated the association of ... See full document
11
Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low density lipoprotein and exhibit decreased activity of the lipoprotein associated phospholipase A2
... ERA patients were treated with methotrexate (0.2 mg/kg/ week), and prednisone (7.5 mg/day). The dose of methotrex- ate remained stable during the study, while the dose of pred- nisone was tapered to 5 mg/day according to ... See full document
8
“Study of Wattakaka Volubilis on Tissue Lipids and Antioxidants in Aluminium Sulphate Exposed Rats” by S.Usha Rani, R.Anuradha, India.
... Antioxidant enzymes were measured by Catalase(CAT) 32 , Super oxide dismutase (SOD) 33 , Lipid peroxidation (LPO) 34 , Reduced glutathione (GSH) 35 , Glutathione peroxidase (GPx) 36 and Glutathione reductase (GR) 37 ... See full document
6
ANTI-HYPERLIPIDEMIC ACTIVITY OF LEAVES OF Sphaeranthus indicus ON ATHEROGENIC DIET INDUCED HYPERLIPIDEMIC IN RATS
... Low density lipoprotein (LDL), High density lipoprotein (HDL), Very low density lipoprotein (VLDL), Triglycerides and Atherogenic index, and Total cholesterol level in ... See full document
5
Lipoprotein subclass profiles in young adults born preterm at very low birth weight
... sive lipoprotein subclass data at both in the fasting state and 2-hours after an oral glucose ...rather high num- ber of lipoprotein measures analysed, this created a statistically difficult ... See full document
6
Rat Intestine Secretes Discoid High Density Lipoprotein
... lymph high density lipoprotein when compared to fatty lymph and serum high density ...lymph high density lipoprotein and 30% of fatty lymph high ... See full document
8
Study of Lipid Profile Changes in Cirrhosis of Liver
... It was first described towards the end of 18th century by French chemist De Fourerol. It is distributed in all cells of the body but particularly in nervous tissue. Cholesterol is the most important compound of those ... See full document
143
New developments in atherosclerosis: clinical potential of PCSK9 inhibition
... reduction below 70 mg/dL was achieved in 79.3% of patients, and the reduction in LDL-C was maintained for the duration of treatment (–56% after 78 weeks). Alirocumab also signifi- cantly reduced non-high ... See full document
9
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF C to induce tumorigenesis
... The secretory factor VEGF-C has been directly implicated in various physiological processes during embryogenesis and human cancers. However, the importance of the conversion of its precursor proVEGF-C to mature VEGF-C in ... See full document
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